2-Amino-5-bromo-4-methyl-3-nitropyridine
- Product Name
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- CAS No.
- 100367-40-6
- Chemical Name
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- Synonyms
- 2-Ami;2-Amino-5-Bromo-4methyl-3-Np;2-AMINO-3-NITRO-5-BROMO-4-PICOLINE;2-AMINO-5-BROMO-3-NITRO-4-PICOLINE;2-Amino-5-bromo-3-nitro-GAMMA-picoline;5-bromo-4-methyl-3-nitro-2-Pyridinamine;5-bromo-4-methyl-3-nitropyridin-2-amine;2-AMino-5-broMo-3-nitro-4-picoline 98%;2-AMINO-5-BROMO-4-METHYL-3-NITROPYRIDINE;2-AMINO-3-NITRO-4-METHYL-5-BROMOPYRIDINE
- CBNumber
- CB6489500
- Molecular Formula
- C6H6BrN3O2
- Formula Weight
- 232.03
- MOL File
- 100367-40-6.mol
2-Amino-5-bromo-4-methyl-3-nitropyridine Property
- Melting point:
- 160-164
- Boiling point:
- 314.1±37.0 °C(Predicted)
- Density
- 1.795±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 0.78±0.50(Predicted)
- form
- powder to crystal
- color
- Light yellow to Brown
- CAS DataBase Reference
- 100367-40-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- A2988
- Product name
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $67
- Updated
- 2025/07/31
- Product number
- A2988
- Product name
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $200
- Updated
- 2025/07/31
- Product number
- A601915
- Product name
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A601915
- Product name
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- Packaging
- 10g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- FA55206
- Product name
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
2-Amino-5-bromo-4-methyl-3-nitropyridine Chemical Properties,Usage,Production
Uses
2-Amino-5-bromo-4-methyl-3-nitropyridine is a pyridine derivative. Its molecular structure contains reactive groups of bromine atoms, amino groups and nitric acid, which can be used in a variety of chemical reactions, such as substitution, condensation, and nitro-reduction reactions. It is mainly used in organic synthesis or pharmaceutical intermediates.
Synthesis
6635-86-5
100367-40-6
Part A: The reaction vessel was first purged with inert gas under inert gas protection. 7.50L of acetic acid was added to the vessel and the temperature was maintained at 20-25°C. Subsequently, 1.00 kg of 4-methyl-3-nitropyridin-2-amine (compound of formula 1) was added to form a yellow suspension. Next, 1.07 kg of sodium acetate was added and the reaction mixture changed to a very thick yellow suspension and a slight exothermic phenomenon was observed. After raising the reaction temperature to about 27°C, the reaction was cooled to 15-20°C and samples were taken for analysis by high pressure liquid chromatography (HPLC). A solution of 1.15 kg of bromine (1.1 eq.) with 2.5 L of acetic acid was prepared and a 10/11 portion (i.e., 1.0 eq.) was added dropwise to the reaction vessel over a period of 10-15 minutes, maintaining the temperature at 15-20°C. A slight exotherm was observed during the dropwise addition and proper cooling was required to maintain the temperature not exceeding 20°C. HPLC analysis was performed immediately after dropwise addition and monitored again after 60 minutes and less than 10% of the starting material was found to be remaining. The remaining bromine solution was added and the reaction was continued with stirring for 30-60 minutes until the reaction was complete. At the end of the reaction, 10.0 L of ice water was added and cooled to 11°C to form a suspension. After continued stirring for 30-60 minutes, the product was collected by filtration and washed with 3 x 2.50 L of ice water. The product was dried at 40°C to constant weight to give 1.45 kg of yellow crystals in 96% yield. The melting point of the product was 132 °C. IR (KBr, cm^-1): 1633, 1581, 1538, 1512, 1458, 1377, 1344, 1321, 1244, 869, 779. 1H-NMR (CDCl3, δ, ppm): 2.55 (s, 3H), 5.85 (bs, 2H), 8.25 (s, 1H) .13C-NMR (CDCl3, δ, ppm): 20.81, 112.14, 144.49, 151.91, 153.78 (2C).MS (M+1): 232.Elemental Analysis: C6H6BrN3O2 Calculated Values: C, 31.05; H, 2.60; N, 18.11; Br, 34.43.Measured Values. 30.95; H, 2.42; N, 17.45; Br, 34.80.
References
[1] Patent: US2006/293304, 2006, A1. Location in patent: Page/Page column 28-29
[2] Patent: US2007/32503, 2007, A1. Location in patent: Page/Page column 8-9; 10
[3] Patent: WO2014/125408, 2014, A2. Location in patent: Page/Page column 38
2-Amino-5-bromo-4-methyl-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-bromo-4-methyl-3-nitropyridine manufacturers
- Product
- 2-Amino-5-bromo-4-methyl-3-nitropyridine 100367-40-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Amino-5-bromo-4-methyl-3-nitropyridine 100367-40-6
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Amino-5-bromo-4-methyl-3-nitropyridine 100367-40-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26