3-Amino-2-chloro-4-methylpyridine

Product Name: 3-Amino-2-chloro-4-methylpyridine
CAS No.: 133627-45-9
Chemical Name: 3-Amino-2-chloro-4-methylpyridine
Synonyms: 2-CHLORO-4-METHYLPYRIDIN-3-AMINE;2-CHLORO-3-AMINO-4-METHYLPYRIDINE;Capic;TIMTEC-BB SBB010194;3-Amino-2-chloro-4-p;ASINEX-REAG BAS 13794917;2-CHLORO-3-AMINO-4-PICOLINE;3-AMINO-2-CHLORO-4-PICOLINE;2-Chloro-3-Amino-4-Methylpyrid;2-Chlor-4-Methylpyridin-3-Amin
CBNumber: CB5240863
Molecular Formula: C6H7ClN2
Formula Weight: 142.59
MOL File: 133627-45-9.mol

More

Less

3-Amino-2-chloro-4-methylpyridine Property

Melting point:: 65-70 °C
Boiling point:: 283.3±35.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform, Ethanol
pka: 3.22±0.10(Predicted)
form: Crystals
color: Off White
InChI: InChI=1S/C6H7ClN2/c1-4-2-3-9-6(7)5(4)8/h2-3H,8H2,1H3
InChIKey: UOBCYTOUXLAABU-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C)=C1N
CAS DataBase Reference: 133627-45-9(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-36-39
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708135
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: 97%
Packaging: 5g
Price: $66.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 708135
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: 97%
Packaging: 1g
Price: $24
Updated: 2023/01/07

TCI Chemical

Product number: A1855
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $43
Updated: 2024/03/01

TCI Chemical

Product number: A1855
Product name: 3-Amino-2-chloro-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $129
Updated: 2024/03/01

Alfa Aesar

Product number: H26058
Product name: 3-Amino-2-chloro-4-methylpyridine, 97%
Packaging: 5g
Price: $125
Updated: 2021/12/16

More

Less

3-Amino-2-chloro-4-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Off White Crystals

Uses

3-Amino-2-chloro-4-methylpyridine, also known as CAPIC, is a key intermediate in the production of nevirapine, a non-nucleosidic reverse transcriptase inhibitor that has been established to be clinically useful for the treatment of infection by HIV-1.

Preparation

An improved and commercially valuable process is developed by Ge et al. for the scalable synthesis of 2-chloro-3-amino-4-methylpyridine (CAPIC), a key intermediate of Nevirapine. The synthesis was accomplished in four steps, featuring condensation starting from 4,4-dimethoxyl-2-butanone and cyanoacetamide with ammonium acetate and acetic acid as catalysts. Specifically, a stirred solution of NaOH (15.6 g, 0.39 mol) and water (85 g) at 10 ℃ was added, 10% NaClO (96.8 g, 0.13 mol) and ethanol (80 g). 2-Chloro-3-amido-4- methylpyridine 7 (22 g, 0.13 mol) was added to the reaction mixture, stirring for 1 h. The mixture was heated to 60 ℃ and held for 3 h. After ethanol was removed in a vacuum, the mixture was cooled with an ice-water bath for 15–20 min to precipitate solid. Then, the mixture was filtered, washed with water, and dried to give 15.8 g (85.1% yield) of light yellow solid. 14.7 g of the white solid 2 was obtained via recrystallization in toluene.

References

[1] Xin Ge. “A concise synthesis of 2-chloro-3-amino-4-methylpyridine.” Research on Chemical Intermediates 37 6 (2011): 599–604.

3-Amino-2-chloro-4-methylpyridine Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Hydrochloric acid 3-Amino-4-methylpyridine

Preparation Products

Nevirapine

More

Less

3-Amino-2-chloro-4-methylpyridine Suppliers

Americas 1 Canada 3 China 416 Czech Republic 1 Europe 4 Germany 6 India 44 Indonesia 1 Japan 4 Jordan 1 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 2 United Kingdom 17 United States 53 Global 558

Synbias Ltd.

Tel: --
Fax: --
Email: synbias@synbias.com
Country: Ukraine
ProdList: 180
Advantage: 58

CAS Organic Company

Tel: --
Fax: --
Email: Sales@casorganic.com
Country: Ukraine
ProdList: 5026
Advantage: 34

More

Less

View Lastest Price from 3-Amino-2-chloro-4-methylpyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Amino-2-chloro-4-methylpyridine 133627-45-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-09-18

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Chloro-3-amino-4-methyl pyridine 133627-45-9
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 3-Amino-2-chloro-4-methylpyridine 133627-45-9
Price: US $80.00-800.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-31

133627-45-9, 3-Amino-2-chloro-4-methylpyridineRelated Search:

6-Aminocaproic acid Pyridine DIMETHYLAMINOPYRIDINE, POLYMER-BOUND 4-Dimethylaminopyridine 2-Aminopyridine 2-Chloro-3-pyridinamine 3-Amino-4-methylpyridine 2-Chloro-5-chloromethylpyridine METSULFURON METHYL 4-Methylpyridin-2-amine 4-Aminopyridine 3-Aminopyridine Glycine Tribenuron methyl Thiophanate-methyl Methyl acetate 2-Chloro-3-picoline 2-Chloro-4-methyl-3-nitropyridine

2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE

2-CHLORO-4-METHYLPYRIDIN-3-AMINE

2-CHLORO-3-AMINO-4-PICOLINE

2-CHLORO-3-AMINO-4-METHYLPYRIDINE

3-AMINO-2-CHLORO-4-PICOLINE

ASINEX-REAG BAS 13794917

TIMTEC-BB SBB010194

2-Chloro-3-Amino-4-Methylpyridine,Nevirapine

2-Chloro-3-Amino-4-Methylpyrid

2-chloro-3-amino-4-methylpyridine (intermediate of nevirapine)

3-Pyridinamine,2-chloro-4-methyl-(9CI)

2-chloro-4-methylpyridin-3-amine(3-AMINO-2-CHLORO-4-PICOLINE)

3-Amino-2-chloro-4-methlpyridine

2-CHLORO-4-METHYLPYRIDIN-3-AMINE ,98%

3-AMINO-2-CHLORO-4-PICOLINE (3-AMINO-2-CHLORO-4-METHYLPYRIDINE)

2-Chloro-3-amino-4-methyl pyridine price

-Amino-2-chloro-4-methylpyridine

3-Amino-2-chloro-4-methylpyridine ,98%

3-Amino-2-chloro-4-p

2-Chloro-4-methyl-3-pyridinamine

3-AMino-2-chloro-4-Methyl pyridine (for Nevirapine)

2-Chloro-4-methyl-3-aminopyridine

2-Chloro-3-aMino-4-Methyl pyridine (CAPIC)

3-Pyridinamine, 2-chloro-4-methyl-

Capic

3-Amino-2-chloro-4-methylpyridine 97%

2-Chloro-3-Amino-4-Methylpyridine,Nevirapine Intermediate

2-Chloro-3-animo-4-methylpyridine

3-Amino-2-chloro-4-methylpyridine &gt

3-Amino-2-chloro-4-methylpyridine ISO 9001：2015 REACH

TIANFU CHEM--2-Chloro-3-amino-4-methyl pyridine

2-Chlor-4-Methylpyridin-3-Amin

2 Chloro 3 Amino 4 Methyl Pyridene

133627-45-9

133627-45

33627-45-9

C6H7C1N2

C7H4ClF3O4

Halopyridines

Chloropyridines

Building Blocks

C5 to C6

C6

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

API Intermediate

(intermediate of nevirapine)

Aromatics Compounds

Chloropyridines

Halopyridines

Aromatics

Bases & Related Reagents

Nucleotides

Pyridines, Pyrimidines, Purines and Pteredines

pharmacetical

Amines

Pyridines