2-Chloro-3-fluoro-4-iodopyridine
- Product Name
- 2-Chloro-3-fluoro-4-iodopyridine
- CAS No.
- 148639-07-0
- Chemical Name
- 2-Chloro-3-fluoro-4-iodopyridine
- Synonyms
- 2-CHLORO-3-FLUORO-4-IODOPYRIDINE;Pyridine, 2-chloro-3-fluoro-4-iodo-;2-Chloro-3-fluoro-4-iodopyridine 95+%;2-CHLORO-3-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB7225275
- Molecular Formula
- C5H2ClFIN
- Formula Weight
- 257.43
- MOL File
- 148639-07-0.mol
2-Chloro-3-fluoro-4-iodopyridine Property
- Melting point:
- 97 °C
- Boiling point:
- 246.1±35.0 °C(Predicted)
- Density
- 2.129±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -0.22±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C5H2ClFIN/c6-5-4(7)3(8)1-2-9-5/h1-2H
- InChIKey
- GONULLRFSHKLBS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(I)=C1F
- CAS DataBase Reference
- 148639-07-0(CAS DataBase Reference)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C3375
- Product name
- 2-Chloro-3-fluoro-4-iodopyridine
- Packaging
- 1G
- Price
- $144
- Updated
- 2025/07/31
- Product number
- C368263
- Product name
- 2-Chloro-3-fluoro-4-iodopyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W3243
- Product name
- 2-Chloro-3-fluoro-4-iodopyridine
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
- Product number
- AK-33366
- Product name
- 2-Chloro-3-fluoro-4-iodopyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 071628
- Product name
- 2-Chloro-3-fluoro-4-iodopyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
2-Chloro-3-fluoro-4-iodopyridine Chemical Properties,Usage,Production
Uses
2-Chloro-3-fluoro-4-iodopyridine is a polyhalogenated compound with a wide uses. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
17282-04-1
148639-07-0
The general procedure for the synthesis of 2-chloro-3-fluoro-4-iodopyridine using 2-chloro-3-fluoropyridine as a starting material was as follows: a lithium 2-diisopropylammonium solution (2M, dissolved in a mixed solvent of tetrahydrofuran/ethylbenzene/heptane, 155 mL, 0.31 mol) was added slowly and dropwise over a period of 40 min at -70 °C to a 2-chloro-3-fluoropyridine (31 g, 0.235 mol) tetrahydrofuran (200 mL) solution. After the dropwise addition, the reaction mixture was continued to be stirred at -70 °C for 4 hours. Subsequently, a solution of iodine (69 g, 0.2 mol) in tetrahydrofuran (100 mL) was added dropwise over a period of 30 min, and after keeping the reaction at -70 °C for 30 min, the reaction was slowly warmed up to room temperature, and the warming up process was controlled to be completed in 1 hour. The reaction mixture was poured into aqueous sodium bisulfite solution (20% v/v, 2 L) and extracted with ether (3 x 300 mL). The organic phases were combined and washed sequentially with aqueous sodium metabisulfite (20% v/v, 2L) and water (200 mL), dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a colorless oily substance. The oily material was ground with ether to afford the target product 2-chloro-3-fluoro-4-iodopyridine as a reddish brown solid (28 g, 46% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.87 (d, J=5.0 Hz, 1H), 7.66 (ddd, J=5.0,4.0,0.4 Hz, 1H).
References
[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 107-108
[2] Tetrahedron, 1993, vol. 49, # 16, p. 3325 - 3342
2-Chloro-3-fluoro-4-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-3-fluoro-4-iodopyridine Suppliers
- Tel
- 13816107857
- Fax
- qq: 276312098
- sales@fortunechem-sh.com
- Country
- China
- ProdList
- 984
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2806
- Advantage
- 65
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
View Lastest Price from 2-Chloro-3-fluoro-4-iodopyridine manufacturers
- Product
- 2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02