ChemicalBook > CAS DataBase List > 2-Chloro-3-fluoro-4-iodopyridine

2-Chloro-3-fluoro-4-iodopyridine

Product Name: 2-Chloro-3-fluoro-4-iodopyridine
CAS No.: 148639-07-0
Chemical Name: 2-Chloro-3-fluoro-4-iodopyridine
Synonyms: 2-CHLORO-3-FLUORO-4-IODOPYRIDINE;Pyridine, 2-chloro-3-fluoro-4-iodo-;2-Chloro-3-fluoro-4-iodopyridine 95+%;2-CHLORO-3-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber: CB7225275
Molecular Formula: C5H2ClFIN
Formula Weight: 257.43
MOL File: 148639-07-0.mol

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2-Chloro-3-fluoro-4-iodopyridine Property

Melting point:: 97 °C
Boiling point:: 246.1±35.0 °C(Predicted)
Density: 2.129±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: -0.22±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C5H2ClFIN/c6-5-4(7)3(8)1-2-9-5/h1-2H
InChIKey: GONULLRFSHKLBS-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(I)=C1F
CAS DataBase Reference: 148639-07-0(CAS DataBase Reference)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3375
Product name: 2-Chloro-3-fluoro-4-iodopyridine
Packaging: 1G
Price: $144
Updated: 2025/07/31

TRC

Product number: C368263
Product name: 2-Chloro-3-fluoro-4-iodopyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: AK-33366
Product name: 2-Chloro-3-fluoro-4-iodopyridine
Purity: 95%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Matrix Scientific

Product number: 071628
Product name: 2-Chloro-3-fluoro-4-iodopyridine
Purity: 98%
Packaging: 1g
Price: $40
Updated: 2021/12/16

AK Scientific

Product number: W3243
Product name: 2-Chloro-3-fluoro-4-iodopyridine
Packaging: 1g
Price: $99
Updated: 2021/12/16

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2-Chloro-3-fluoro-4-iodopyridine Chemical Properties,Usage,Production

Uses

2-Chloro-3-fluoro-4-iodopyridine is a polyhalogenated compound with a wide uses. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

17282-04-1

148639-07-0

The general procedure for the synthesis of 2-chloro-3-fluoro-4-iodopyridine using 2-chloro-3-fluoropyridine as a starting material was as follows: a lithium 2-diisopropylammonium solution (2M, dissolved in a mixed solvent of tetrahydrofuran/ethylbenzene/heptane, 155 mL, 0.31 mol) was added slowly and dropwise over a period of 40 min at -70 °C to a 2-chloro-3-fluoropyridine (31 g, 0.235 mol) tetrahydrofuran (200 mL) solution. After the dropwise addition, the reaction mixture was continued to be stirred at -70 °C for 4 hours. Subsequently, a solution of iodine (69 g, 0.2 mol) in tetrahydrofuran (100 mL) was added dropwise over a period of 30 min, and after keeping the reaction at -70 °C for 30 min, the reaction was slowly warmed up to room temperature, and the warming up process was controlled to be completed in 1 hour. The reaction mixture was poured into aqueous sodium bisulfite solution (20% v/v, 2 L) and extracted with ether (3 x 300 mL). The organic phases were combined and washed sequentially with aqueous sodium metabisulfite (20% v/v, 2L) and water (200 mL), dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a colorless oily substance. The oily material was ground with ether to afford the target product 2-chloro-3-fluoro-4-iodopyridine as a reddish brown solid (28 g, 46% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.87 (d, J=5.0 Hz, 1H), 7.66 (ddd, J=5.0,4.0,0.4 Hz, 1H).

References

[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 107-108
[2] Tetrahedron, 1993, vol. 49, # 16, p. 3325 - 3342

2-Chloro-3-fluoro-4-iodopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-3-fluoro-4-iodopyridine manufacturers

Dideu Industries Group Limited

Product: 2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-01

Career Henan Chemical Co

Product: 2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-02

148639-07-0, 2-Chloro-3-fluoro-4-iodopyridineRelated Search:

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2-CHLORO-3-FLUORO-4-IODOPYRIDINE

2-Chloro-3-fluoro-4-iodopyridine 95+%

Pyridine, 2-chloro-3-fluoro-4-iodo-

2-CHLORO-3-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH

148639-07-0

C5H2NClFI

C5H2ClFIN

Pyridine

Boronic Acid

Fluorin-contained pyridine series