2-Chloro-3-methyl-5-nitropyridine

Product Name: 2-Chloro-3-methyl-5-nitropyridine
CAS No.: 22280-56-4
Chemical Name: 2-Chloro-3-methyl-5-nitropyridine
Synonyms: 2-CHLORO-5-NITRO-3-PICOLINE;2-C;BUTTPARK 95\50-52;TIMTEC-BB SBB003831;2-Chloro-5-nitro-3-picoline,98%;2-CHLORO-5-NITRO-3-METHYLPYRIDINE;2-CHLORO-3-METHYL-5-NITROPYRIDINE;2-Chloro-5-nitro-3-picoline, 98% 1GR;Pyridine, 2-chloro-3-methyl-5-nitro-;2-Chloro-3-methyl-5-nitropyridine,99%
CBNumber: CB7319385
Molecular Formula: C6H5ClN2O2
Formula Weight: 172.57
MOL File: 22280-56-4.mol

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2-Chloro-3-methyl-5-nitropyridine Property

Melting point:: 45-50 °C
Boiling point:: 145 °C / 18mmHg
Density: 1.5610 (rough estimate)
refractive index: 1.5500 (estimate)
Flash point:: >110°C
storage temp.: 2-8°C
solubility: soluble in Methanol
form: Crystalline Powder
pka: -3.61±0.10(Predicted)
color: Light beige to cream
Sensitive: Hygroscopic
InChI: InChI=1S/C6H5ClN2O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3
InChIKey: OSIOIGXJUZTWRI-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C([N+]([O-])=O)C=C1C
CAS DataBase Reference: 22280-56-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22-41-37/38-22
Safety Statements: 37/39-26-39
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 736961
Product name: 2-Chloro-3-methyl-5-nitropyridine
Purity: 97%
Packaging: 1g
Price: $41.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 736961
Product name: 2-Chloro-3-methyl-5-nitropyridine
Purity: 97%
Packaging: 5g
Price: $178
Updated: 2023/01/07

TCI Chemical

Product number: C2020
Product name: 2-Chloro-3-methyl-5-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: C2020
Product name: 2-Chloro-3-methyl-5-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $109
Updated: 2025/07/31

Usbiological

Product number: 294989
Product name: 2-C-
Packaging: 1g
Price: $2032
Updated: 2021/12/16

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2-Chloro-3-methyl-5-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light beige to cream colored crystalline powder

Uses

2-Chloro-3-methyl-5-nitropyridine is a nitropyridine compound, mainly used as an organic synthetic raw material or pharmaceutical intermediate.

Synthesis

21901-34-8

22280-56-4

Synthesis of compound 20: Compound 19 (3-methyl-5-nitropyridin-2(1H)-one, 16.60 g, 0.1 mol) was added to 80 mL of phosphoryl chloride (POCl3), heated to reflux and maintained for 8 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by distillation. The reaction mixture was slowly poured into 300 g of crushed ice and a dark brown precipitate precipitated. The precipitate was collected by filtration to give 16.18 g of the target product 2-chloro-3-methyl-5-nitropyridine in 87.1% yield. The melting point of the product was 44.5-45.8 °C (literature value: 47-48 °C) [J.O.C., 1949, 14, 328-332].

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 23, p. 7653 - 7668
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 10
[3] Journal of Organic Chemistry, 1949, vol. 14, p. 328,331
[4] Patent: US2010/29684, 2010, A1. Location in patent: Page/Page column 14
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995

2-Chloro-3-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-3-methyl-5-nitropyridine Suppliers

Americas 1 Belgium 2 Canada 1 China 213 Europe 2 France 2 Germany 2 India 20 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 17 United States 49 Global 312

Changzhou Helios Biomedical Science and Technology Co.,LTD.

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Capot Chemical Co., Ltd

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View Lastest Price from 2-Chloro-3-methyl-5-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-3-methyl-5-nitropyridine 22280-56-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-3-methyl-5-nitropyridine 22280-56-4
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1g
Purity: 98%
Supply Ability: 50tons
Release date: 2020-05-12

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-3-methyl-5-nitropyridine 22280-56-4
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

22280-56-4, 2-Chloro-3-methyl-5-nitropyridineRelated Search:

Bensulfuron methyl Kresoxim-methyl 2,6-Lutidine Methylparaben 4-Methylpyridine 2-Chloro-5-nitropyridine 2-Chloro-5-chloromethylpyridine Methyl acrylate Methyl acetate Azamethiphos 2-Bromo-5-nitropyridine 2,4,6-Collidine 2-Chloro-3-picoline 2-Chloro-3-nitropyridine 2-Methyl-5-nitropyridine Thiophanate-methyl 2-CHLORO-6-METHYL-3-NITROPYRIDINE,2-CHLORO-3-NITRO-6-PICOLINE (2-CHLORO-6-METHYL-3-NITROPYRIDINE),6-chloro-2-methyl-5-nitropyridine Methyl

2-Chloro-3-methyl-5-nitropyridine,99%

BUTTPARK 95\50-52

2-CHLORO-5-NITRO-3-METHYLPYRIDINE

2-CHLORO-5-NITRO-3-PICOLINE

2-CHLORO-3-METHYL-5-NITROPYRIDINE

2-Chloro-3-methyl-5-nitropyridine 2-Chloro-5-nitro-3-picoline

2-CHLORO-5-NITRO-3-PICOLINE (2-CHLORO-3-METHYL-5-NITROPYRIDINE)

TIMTEC-BB SBB003831

2-Chloro-3-methyl-5-nitropyridine ,98%

2-Chloro-5-nitro-3-picoline,98%

2-Chloro-5-nitro-3-picoline, 98% 1GR

2-C

2-Chloro-3-methyl-5-nitropyridine &gt

Pyridine, 2-chloro-3-methyl-5-nitro-

2-Chloro-3-methyl-5-nitropyridine ISO 9001：2015 REACH

22280-56-4

Chloropyridines

Halopyridines

Heterocycle-Pyridine series

Heterocyclic Building Blocks

Building Blocks

Chemical Synthesis

Halides

Pyridines

Chloropyridines

Halopyridines

Boronic Acid

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines

Pyridine series

compounds of pyridine

C6