3-Bromo-5-fluoro-2-methoxypyrdine

Product Name: 3-Bromo-5-fluoro-2-methoxypyrdine
CAS No.: 884494-81-9
Chemical Name: 3-Bromo-5-fluoro-2-methoxypyrdine
Synonyms: uoro-2-methoxypyridine;3-BROMO-5-FLUORO-2-METHOXYPYRDINE;3-Bromo-2-Methoxy-5-fluoropyridine;3-BROMO-5-FLUORO-2-METHOXYPYRIDINE;Pyridine, 3-bromo-5-fluoro-2-methoxy-;3-Bromo-5-fluoro-2-methoxypyridine 98%;3-Bromo-5-fluoro-2-methoxypyridine ,98%;3-Bromo-5-fluoropyridin-2-yl methyl ether;3-BROMO-5-FLUORO-2-METHOXYPYRIDINE, 98%min;3-BROMO-5-FLUORO-2-METHOXYPYRIDINE ISO 9001：2015 REACH
CBNumber: CB0776723
Molecular Formula: C6H5BrFNO
Formula Weight: 206.01
MOL File: 884494-81-9.mol

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3-Bromo-5-fluoro-2-methoxypyrdine Property

Boiling point:: 188.4±35.0 °C(Predicted)
Density: 1.621±0.06 g/cm3(Predicted)
refractive index: 1.5390 to 1.5430
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.38±0.20(Predicted)
form: Liquid
Appearance: Colorless to light yellow Solid-Liquid Mixture
Sensitive: Light Sensitive
CAS DataBase Reference: 884494-81-9

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5134
Product name: 3-Bromo-5-fluoro-2-methoxypyridine
Purity: >97.0%(GC)
Packaging: 1g
Price: $50
Updated: 2025/07/31

TRC

Product number: B692483
Product name: 3-Bromo-5-fluoro-2-methoxypyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B692483
Product name: 3-Bromo-5-fluoro-2-methoxypyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: B692483
Product name: 3-Bromo-5-fluoro-2-methoxypyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B1641
Product name: 3-Bromo-5-fluoro-2-methoxypyridine
Purity: 98%
Packaging: 5g
Price: $40
Updated: 2021/12/16

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3-Bromo-5-fluoro-2-methoxypyrdine Chemical Properties,Usage,Production

Chemical Properties

2-Methoxy-3-bromo-5-fluoropyridine is liquid at room temperature and pressure, with a density of 1.6 g/cm3 and a boiling point of 188.4±35.0 °C (760 mmH) at one atmospheric pressure. In organic synthetic transformations, bromine atoms on the pyridine ring can be reacted with an arylboron reagent to join two aryl groups at the 3 position in the presence of a couple, and furthermore the bromine atoms on the pyridine ring can also be converted to boron units by reacting with triisopropyl borate in the presence of n-butyllithium. In addition, the bromine atom on the pyridine ring can be converted to a boron unit by reacting with triisopropyl borate in the presence of n-butyllithium. In addition, due to the electron-deficient nature of the pyridine ring, the bromine atom on the pyridine ring can be attacked by a nucleophilic reagent to obtain a debromofunctionalized product.

Uses

3-Bromo-5-fluoro-2-methoxypyridine is a compound used in the synthesis of 5-Fluoro-2-methoxy-3-(2R)-2-pyrrolidinylpyridine (1213093-30-1).

Synthesis

884494-94-4

74-88-4

884494-81-9

General steps: 1. Prepare raw material: (R)-5-fluoro-2-methoxy-3-(pyrrolidin-2-yl)pyridine. 2. Step A: Synthesis of 3-bromo-5-fluoro-2-methoxypyridine. a. Add 3-bromo-5-fluoropyridin-2(1H)-one (10.0 g, 52.1 mmol) and Ag2CO3 (10.0 g, 36.5 mmol) to toluene (100 mL). b. Slowly add iodomethane (3.89 mL, 62.5 mmol). c. The reaction mixture was stirred at room temperature overnight. d. Upon completion of the reaction, filter through diatomaceous earth and wash the solids with toluene. e. The filtrate was concentrated to give the crude product. f. The crude product was purified by silica gel column chromatography (eluent: 5-25% EtOAc/hexane) to afford 3-bromo-5-fluoro-2-methoxypyridine (4.70 g, 43.8% yield) as a colorless oil.

References

[1] Patent: WO2011/6074, 2011, A1. Location in patent: Page/Page column 74-75

3-Bromo-5-fluoro-2-methoxypyrdine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-5-fluoro-2-methoxypyrdine Suppliers

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View Lastest Price from 3-Bromo-5-fluoro-2-methoxypyrdine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Bromo-5-fluoro-2-methoxypyrdine 884494-81-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2025-05-22

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Bromo-5-fluoro-2-methoxypyrdine 884494-81-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-10

Career Henan Chemical Co

Product: 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE 884494-81-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-02

884494-81-9, 3-Bromo-5-fluoro-2-methoxypyrdineRelated Search:

3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE 2-Chloro-3-pyridinamine 2-Chloro-3-fluoropyridine 2-Methoxy-5-(trifluoromethyl)pyridine 3-BROMO-2-METHOXY-6-PICOLINE 5-AMINO-3-BROMO-2-METHOXYPYRIDINE 2-Methoxy-3-nitropyridine 5-BROMO-2-METHOXY-3-NITRO-PYRIDINE 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL 2-Methoxy-3-fluoro-5-bromopyridine 6-Chloro-2-methoxy-3-nitropyridine 2-METHOXY-3,5-DIBROMO-PYRIDINE 2-Methoxy-5-nitro-3-picoline 2-Methoxy-3-(trifluoromethyl)pyridine 5-BROMO-2-METHOXY-3-CYANOPYRIDINE 3-Iodo-2-methoxypyridine 6-BROMO-2-FLUORO-3-METHOXYPYRIDINE 5-BROMO-2-FLUORO-3-METHOXYPYRIDINE

3-BROMO-5-FLUORO-2-METHOXYPYRIDINE

3-Bromo-5-fluoro-2-methoxypyridine ,98%

uoro-2-methoxypyridine

3-Bromo-5-fluoro-2-methoxypyridine 98%

Pyridine, 3-bromo-5-fluoro-2-methoxy-

3-Bromo-5-fluoropyridin-2-yl methyl ether

3-BROMO-5-FLUORO-2-METHOXYPYRIDINE ISO 9001：2015 REACH

3-Bromo-2-Methoxy-5-fluoropyridine

3-BROMO-5-FLUORO-2-METHOXYPYRDINE

3-BROMO-5-FLUORO-2-METHOXYPYRIDINE, 98%min

884494-81-9

C6H5BrFNO

Fluorine series

Organohalides

Pyridine

Pyridine Series