3-Bromo-5-fluoro-2-methoxypyrdine
- Product Name
- 3-Bromo-5-fluoro-2-methoxypyrdine
- CAS No.
- 884494-81-9
- Chemical Name
- 3-Bromo-5-fluoro-2-methoxypyrdine
- Synonyms
- uoro-2-methoxypyridine;3-BROMO-5-FLUORO-2-METHOXYPYRDINE;3-Bromo-2-Methoxy-5-fluoropyridine;3-BROMO-5-FLUORO-2-METHOXYPYRIDINE;Pyridine, 3-bromo-5-fluoro-2-methoxy-;3-Bromo-5-fluoro-2-methoxypyridine 98%;3-Bromo-5-fluoro-2-methoxypyridine ,98%;3-Bromo-5-fluoropyridin-2-yl methyl ether;3-BROMO-5-FLUORO-2-METHOXYPYRIDINE, 98%min;3-BROMO-5-FLUORO-2-METHOXYPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB0776723
- Molecular Formula
- C6H5BrFNO
- Formula Weight
- 206.01
- MOL File
- 884494-81-9.mol
3-Bromo-5-fluoro-2-methoxypyrdine Property
- Boiling point:
- 188.4±35.0 °C(Predicted)
- Density
- 1.621±0.06 g/cm3(Predicted)
- refractive index
- 1.5390 to 1.5430
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.38±0.20(Predicted)
- form
- Liquid
- Appearance
- Colorless to light yellow Solid-Liquid Mixture
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 884494-81-9
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5134
- Product name
- 3-Bromo-5-fluoro-2-methoxypyridine
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- B692483
- Product name
- 3-Bromo-5-fluoro-2-methoxypyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B692483
- Product name
- 3-Bromo-5-fluoro-2-methoxypyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B692483
- Product name
- 3-Bromo-5-fluoro-2-methoxypyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B1641
- Product name
- 3-Bromo-5-fluoro-2-methoxypyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
3-Bromo-5-fluoro-2-methoxypyrdine Chemical Properties,Usage,Production
Chemical Properties
2-Methoxy-3-bromo-5-fluoropyridine is liquid at room temperature and pressure, with a density of 1.6 g/cm3 and a boiling point of 188.4±35.0 °C (760 mmH) at one atmospheric pressure. In organic synthetic transformations, bromine atoms on the pyridine ring can be reacted with an arylboron reagent to join two aryl groups at the 3 position in the presence of a couple, and furthermore the bromine atoms on the pyridine ring can also be converted to boron units by reacting with triisopropyl borate in the presence of n-butyllithium. In addition, the bromine atom on the pyridine ring can be converted to a boron unit by reacting with triisopropyl borate in the presence of n-butyllithium. In addition, due to the electron-deficient nature of the pyridine ring, the bromine atom on the pyridine ring can be attacked by a nucleophilic reagent to obtain a debromofunctionalized product.
Uses
3-Bromo-5-fluoro-2-methoxypyridine is a compound used in the synthesis of 5-Fluoro-2-methoxy-3-(2R)-2-pyrrolidinylpyridine (1213093-30-1).
Synthesis
884494-94-4
74-88-4
884494-81-9
General steps: 1. Prepare raw material: (R)-5-fluoro-2-methoxy-3-(pyrrolidin-2-yl)pyridine. 2. Step A: Synthesis of 3-bromo-5-fluoro-2-methoxypyridine. a. Add 3-bromo-5-fluoropyridin-2(1H)-one (10.0 g, 52.1 mmol) and Ag2CO3 (10.0 g, 36.5 mmol) to toluene (100 mL). b. Slowly add iodomethane (3.89 mL, 62.5 mmol). c. The reaction mixture was stirred at room temperature overnight. d. Upon completion of the reaction, filter through diatomaceous earth and wash the solids with toluene. e. The filtrate was concentrated to give the crude product. f. The crude product was purified by silica gel column chromatography (eluent: 5-25% EtOAc/hexane) to afford 3-bromo-5-fluoro-2-methoxypyridine (4.70 g, 43.8% yield) as a colorless oil.
References
[1] Patent: WO2011/6074, 2011, A1. Location in patent: Page/Page column 74-75
3-Bromo-5-fluoro-2-methoxypyrdine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Bromo-5-fluoro-2-methoxypyrdine manufacturers
- Product
- 3-Bromo-5-fluoro-2-methoxypyrdine 884494-81-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2025-05-22
- Product
- 3-Bromo-5-fluoro-2-methoxypyrdine 884494-81-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-10
- Product
- 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE 884494-81-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02