3-Iodo-2-methoxypyridine
- Product Name
- 3-Iodo-2-methoxypyridine
- CAS No.
- 112197-15-6
- Chemical Name
- 3-Iodo-2-methoxypyridine
- Synonyms
- 2-METHOXY-3-IODOPYRIDINE;3-IODO-2-METHOXYPYRIDINE;5-Iodo-2-Methoxypyridinne;Anhydrous lithium acetate;Pyridine,3-iodo-2-Methoxy-;3-Iodo-2-methoxypyridine>3-IODO-2-METHOXYPYRIDINE 99%;3-Iodo-2-methoxypyridine,96%;3-Iodo-2-Methoxypyridine, 97+%;2-Amino-3-bromo-6-nitropyridine
- CBNumber
- CB9175624
- Molecular Formula
- C6H6INO
- Formula Weight
- 235.02
- MOL File
- 112197-15-6.mol
3-Iodo-2-methoxypyridine Property
- Melting point:
- 66 °C(Solv: hexane (110-54-3))
- Boiling point:
- 131-133 °C (43 mmHg)
- Density
- 1.831 g/mL at 25 °C
- refractive index
- 1.617-1.619
- Flash point:
- >110℃
- storage temp.
- 2-8°C
- pka
- 1.38±0.10(Predicted)
- form
- clear liquid
- color
- Light yellow to Brown
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C6H6INO/c1-9-6-5(7)3-2-4-8-6/h2-4H,1H3
- InChIKey
- BXCHJERCAUZLOE-UHFFFAOYSA-N
- SMILES
- C1(OC)=NC=CC=C1I
- CAS DataBase Reference
- 112197-15-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-20/21/22-41-37/38-22-36/37/39
- Safety Statements
- 36/37/39-26-37
- RIDADR
- UN 3334
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 692816
- Product name
- 3-Iodo-2-methoxypyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $49.8
- Updated
- 2023/06/20
- Product number
- I0924
- Product name
- 3-Iodo-2-methoxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- I0924
- Product name
- 3-Iodo-2-methoxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $143
- Updated
- 2025/07/31
- Product number
- I737070
- Product name
- 3-Iodo-2-methoxypyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 016060
- Product name
- 3-Iodo-2-methoxy-pyridine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
3-Iodo-2-methoxypyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Synthesis
1628-89-3
112197-15-6
The general procedure for the synthesis of 3-iodo-2-methoxypyridine using 2-methoxypyridine as starting material was as follows: firstly, [Li(TMP)Zn(tBu)2] was prepared in 0.4 mmol scale THF solution according to the literature method. To this solution, 2-methoxypyridine (0.042 mL, 0.4 mmol) was added and the reaction mixture was stirred at room temperature for 2 h to obtain a light orange solution. Subsequently, the solution was cooled to 0°C and the reaction was quenched with I2 (508 mg, dissolved in 1 mL THF) and stirring was continued for 1 hour. Upon completion of the reaction, 10% Na2S2O3 solution was added until the solution was bleached and the product was extracted with DCM (3 x 1 mL). The organic phases were combined, dried with MgSO4 and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography using heptane:DCM (20:80→40:60) as eluent to afford 3-iodo-2-methoxypyridine (2a) as a colorless oil (87.1 mg, 92% yield).1H NMR (400 MHz, CDCl3) δ ppm 4.00 (s, 3H), 6.65 (dd, J = 7.61, 4.88 Hz, 1H), 8.03 (dd, J = 7.61, 1.76 Hz, 1H), 8.13 (dd, J = 4.88, 1.76 Hz, 1H). The data obtained are in agreement with literature reports.
References
[1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205
[2] Tetrahedron Letters, 2011, vol. 52, # 36, p. 4590 - 4594
[3] Journal of the American Chemical Society, 2004, vol. 126, # 34, p. 10526 - 10527
[4] Journal of the American Chemical Society, 2007, vol. 129, # 7, p. 1921 - 1930
[5] Chemical Communications, 2014, vol. 50, # 85, p. 12859 - 12862
3-Iodo-2-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Iodo-2-methoxypyridine manufacturers
- Product
- 3-Iodo-2-methoxypyridine 112197-15-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 3-Iodo-2-methoxypyridine 112197-15-6
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 3-Iodo-2-methoxypyridine 112197-15-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-18