ChemicalBook > CAS DataBase List > 2-Chloronicotinic acid

2-Chloronicotinic acid

Product Name
2-Chloronicotinic acid
CAS No.
2942-59-8
Chemical Name
2-Chloronicotinic acid
Synonyms
2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;AKOS BBS-00004231;2 - chloro niacin;oronicotinic acid;RARECHEM AL BO 0287;TIMTEC-BB SBB004002
CBNumber
CB7714896
Molecular Formula
C6H4ClNO2
Formula Weight
157.55
MOL File
2942-59-8.mol
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2-Chloronicotinic acid Property

Melting point:
176-178 °C (dec.)(lit.)
Boiling point:
316.8±22.0 °C(Predicted)
Density 
1.470±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO, Ethyl Acetate (Slightly)
pka
2.07±0.25(Predicted)
form 
Powder
color 
White to cream
BRN 
119023
InChI
InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)
InChIKey
IBRSSZOHCGUTHI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC=C1C(O)=O
LogP
0.988
CAS DataBase Reference
2942-59-8(CAS DataBase Reference)
EPA Substance Registry System
2-Chloronicotinic acid (2942-59-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
150339
Product name
2-Chloropyridine-3-carboxylic acid
Purity
99%
Packaging
10g
Price
$49.5
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2305
Product name
Flunixin Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
1274629
Product name
Flunixin Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$596
Updated
2024/03/01
TCI Chemical
Product number
C1108
Product name
2-Chloronicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$21
Updated
2024/03/01
TCI Chemical
Product number
C1108
Product name
2-Chloronicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
250g
Price
$99
Updated
2024/03/01
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2-Chloronicotinic acid Chemical Properties,Usage,Production

Chemical Properties

white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.

Uses

2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.

Application

2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.

Preparation

Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.

Definition

ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.

2-Chloronicotinic acid Preparation Products And Raw materials

Raw materials

2-Chloro-3-methylpyridine 3-Picoline Diisopropylamine 2-chloro-3-trichloromethylpyridine 2-Chloro-5-methylpyridine Nicotinic acid N-oxide

Preparation Products

Diflufenican 2-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID 2-(ETHYLTHIO)NICOTINIC ACID
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View Lastest Price from 2-Chloronicotinic acid manufacturers

Hebei Andu Technology Com.,Ltd
Product
2-Chloronicotinic acid 2942-59-8
Price
US $3.50/kg
Min. Order
1kg
Purity
≥98%
Supply Ability
3000tons/month
Release date
2024-08-16
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Chloronicotinic Acid 2942-59-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-20
Hebei Weibang Biotechnology Co., Ltd
Product
Synephrine hydrochloride 2942-59-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-14

2942-59-8, 2-Chloronicotinic acidRelated Search:

Glycine 3-Aminopyridine 3-Hydroxypyridine 2-Chloro-3-fluoropyridine 2-Chloro-3-iodopyridine Folic acid 2-Picolinic acid Epichlorohydrin Ethyl 2-(Chlorosulfonyl)acetate Quinolinic acid 2-Chloro-5-chloromethylpyridine 2,5-PYRIDINEDICARBOXYLIC ACID 2-Chloro-3-cyanopyridine Xanthinol nicotinate 3-Bromo-2-chloropyridine Pentachloropyridine Isonicotinic acid Clopidol Chloronicotinic Acid

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