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Xanthinol nicotinate

Product Name
Xanthinol nicotinate
CAS No.
437-74-1
Chemical Name
Xanthinol nicotinate
Synonyms
xavin;vedrin;sk331a;sadamin;contamex;teonicol;angiomin;stenalgil;complamin;complamex
CBNumber
CB2255507
Molecular Formula
C19H26N6O6
Formula Weight
434.45
MOL File
437-74-1.mol
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Xanthinol nicotinate Property

Melting point:
180°
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Water (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
Water: 250 mg/mL (575.44 mM)
CAS DataBase Reference
437-74-1(CAS DataBase Reference)
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Safety

WGK Germany 
2
RTECS 
QT1500000
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
X499960
Product name
XanthinolNicotinate
Packaging
10mg
Price
$85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004619
Product name
XANTHINOL NICOTINATE
Purity
95.00%
Packaging
5G
Price
$123.9
Updated
2021/12/16
Matrix Scientific
Product number
059744
Product name
7-(2-Hydroxy-3-((2-hydroxyethyl)(methyl)amino)propyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione nicotinate
Packaging
500mg
Price
$199
Updated
2021/12/16
AK Scientific
Product number
J54310
Product name
Xanthinolniacinate
Packaging
1g
Price
$395
Updated
2021/12/16
AHH
Product number
MT-60443
Product name
Xantinolnicotinate
Purity
98%
Packaging
500g
Price
$450
Updated
2021/12/16
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Xanthinol nicotinate Chemical Properties,Usage,Production

Uses

Sedative, Hypnotic

Uses

Xanthinol Nicotinate is a therapeutic agent that acts as a vasodilator.

Manufacturing Process

To a well-stirred solution of 740 parts by weight of epichlorohydrin in 200 parts by volume of isopropyl alcohol are added 600 parts by weight of methylaminoethanol during about 3 hours at 15°C to 20°C. The heat generated by the condensation is removed by means of a cooling bath. After the addition of the total quantity of methylaminoethanol, stirring is continued for 1 hour at 25°C. The condensation reaction is completed when development of heat reaction can no longer be observed. The solution thus produced of the raw 1-chloro-3-(methylhydroxyethylamino)-propanol-2 in isopropyl alcohol is a colorless viscous liquid which is used without further purification for the subsequent condensation with theophylline.
320 parts by weight of caustic soda are dissolved in 200 parts by weight of water and diluted with 6,000 parts by weight of isopropyl alcohol. 1,584 parts by weight of theophylline-hydrate are added to the well-stirred alcoholic caustic soda solution having a temperature between 50°C to 60°C. As a result, most of the theophylline sodium salt is precipitated and a doughy or pasty white reaction product is formed. While being stirred and heated to the boiling point of alcohol, the solution of the afore-described 1-chloro-3- (methylhydroxyethylamino)-propanol-2 is added dropwise into the reaction vessel during about 3 hours. After further cooking for 2 hours, the alcoholic solution of deposited sodium chloride is filtered off. By vaporizing the alcohol, the 3-(methylhydroxyethylamino)-2-hydroxypropyltheophylline can be obtained as a very viscous oil which contains impurities in the form of by- products.
For purpose of purification, the hot alcoholic solution is mixed with 975 parts by weight of nicotinic acid while being stirred and heated until the nicotinic acid is completely dissolved.
The 3-(methylhydroxyethylamino)-2-hydroxypropyltheophylline-nicotinate separates, while still being warm, in the form of shiny, thin, small sheets. After cooling, the crystallization product is sucked off from the mother liquor and recrystallized from 85% isopropyl alcohol.
The melting point of the pure nicotinic acid salt is 180°C and the yield is 75% to 80% related to the used theophylline. The substance has a nearly neutral reaction and is very readily soluble in water.

Therapeutic Function

Vasodilator

Xanthinol nicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Xanthinol nicotinate Suppliers

Jinan Zhongke Yitong Chemical Co., Ltd.
Tel
0531-88658009
Fax
0531-88956078
Email
lxxcs@163.com
Country
China
ProdList
85
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Wuhan Jiakai Long Technology Development Co., Ltd.
Tel
027-88422011
Fax
027-88774279
Country
China
ProdList
26
Advantage
50
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
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View Lastest Price from Xanthinol nicotinate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Xanthinol nicotinate 437-74-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.5%
Supply Ability
100kg/month
Release date
2021-06-19
Hebei Weibang Biotechnology Co., Ltd
Product
Xanthinol nicotinate 437-74-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
Hebei Mojin Biotechnology Co., Ltd
Product
Xanthinol nicotinate 437-74-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-30

437-74-1, Xanthinol nicotinateRelated Search:


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  • 437-74-1
  • 207-115-7
  • C19H26N6O6
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  • Analytical Chromatography Product Catalog
  • Analytical Standards
  • 437-74-1