3-CHLOROISONICOTINIC ACID ETHYL ESTER

Product Name: 3-CHLOROISONICOTINIC ACID ETHYL ESTER
CAS No.: 211678-96-5
Chemical Name: 3-CHLOROISONICOTINIC ACID ETHYL ESTER
Synonyms: Ethyl 3-chloronicotinate;Ethyl 3-chloroisonicotinate;ethyl 3-chloropyridine-4-carboxylate;3-CHLOROISONICOTINIC ACID ETHYL ESTER;3-CHLOROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER;4-Pyridinecarboxylic acid, 3-chloro-, ethyl ester;4-Pyridinecarboxylicacid,3-chloro-,ethylester(9CI)
CBNumber: CB8729462
Molecular Formula: C8H8ClNO2
Formula Weight: 185.61
MOL File: 211678-96-5.mol

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3-CHLOROISONICOTINIC ACID ETHYL ESTER Property

Boiling point:: 250.2±20.0 °C(Predicted)
Density: 1.245±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 0.91±0.18(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E940108
Product name: Ethyl3-Chloroisonicotinate
Packaging: 2.5g
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y15337
Product name: 3-Chloropyridine-4-carboxylicacidethylester
Purity: 98%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Apolloscientific

Product number: OR950143
Product name: 3-Chloropyridine-4-carboxylicacidethylester
Purity: 95%
Packaging: 1g
Price: $155
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y15337
Product name: 3-Chloropyridine-4-carboxylicacidethylester
Purity: 98%
Packaging: 5g
Price: $80
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0012525
Product name: 3-CHLOROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $495.28
Updated: 2021/12/16

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3-CHLOROISONICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

64-17-5

211678-96-5

General procedure for the synthesis of ethyl 3-chloroisonicotinate from ethanol: 3-chloroisonicotinate (1.0 g, 6.35 mmol) was suspended in thionyl chloride (10 ml) and heated to reflux for 2.5 hours. Upon completion of the reaction, the solution was cooled to room temperature, concentrated to dryness and subsequently azeotropized with toluene (10 ml) to give an oil. The resulting oily substance was slowly added dropwise to a cooled mixture of ethanol (15 ml) and diisopropylethylamine (DIPEA) at 0°C, the dropwise process was controlled to be completed within 10 minutes. The reaction mixture was stirred at room temperature for 18 hours. At the end of the reaction, the reaction solution was concentrated in vacuum, diluted with water (20 ml) and extracted with ethyl acetate (30 ml). The organic phase was dried over anhydrous sodium sulfate and concentrated to give ethyl 3-chloroisonicotinate as an orange oil (1.1 g, 94% yield). The product was characterized by 1H NMR (CDCl3, 400MHz): δ 8.72 (s, 1H), 8.59 (d, J = 4.9Hz, 1H), 7.63 (dd, J = 4.9Hz, 0.5Hz, 1H), 4.44 (q, J = 7.3Hz, 2H), 1.42 (t, J = 7.3Hz, 3H).

References

[1] Patent: WO2008/24724, 2008, A1. Location in patent: Page/Page column 68-69

3-CHLOROISONICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLOROISONICOTINIC ACID ETHYL ESTER Suppliers

China 43 Europe 1 Germany 2 India 1 United States 7 Global 54

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211678-96-5, 3-CHLOROISONICOTINIC ACID ETHYL ESTERRelated Search:

3-Chloroisonicotinic acid ETHYL 2-(TERT-BUTYL)-3,6-DICHLORO-5-CYANOISONICOTINATE ETHYL 2,3,5-TRICHLORO-6-{[(DIMETHYLAMINO)CARBONOTHIOYL]THIO}ISONICOTINATE RARECHEM AL BW 2014 RARECHEM AL BI 0919 SPECS AO-801/41077575 ethyl 2,5-dichloroisonicotinate 3-CHLOROISONICOTINIC ACID ETHYL ESTER

4-Pyridinecarboxylic acid, 3-chloro-, ethyl ester

3-CHLOROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER

3-CHLOROISONICOTINIC ACID ETHYL ESTER

4-Pyridinecarboxylicacid,3-chloro-,ethylester(9CI)

Ethyl 3-chloroisonicotinate

ethyl 3-chloropyridine-4-carboxylate

Ethyl 3-chloronicotinate

211678-96-5

CARBOXYLICESTER