3-CHLOROISONICOTINIC ACID ETHYL ESTER
- Product Name
- 3-CHLOROISONICOTINIC ACID ETHYL ESTER
- CAS No.
- 211678-96-5
- Chemical Name
- 3-CHLOROISONICOTINIC ACID ETHYL ESTER
- Synonyms
- Ethyl 3-chloronicotinate;Ethyl 3-chloroisonicotinate;ethyl 3-chloropyridine-4-carboxylate;3-CHLOROISONICOTINIC ACID ETHYL ESTER;3-CHLOROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER;4-Pyridinecarboxylic acid, 3-chloro-, ethyl ester;4-Pyridinecarboxylicacid,3-chloro-,ethylester(9CI)
- CBNumber
- CB8729462
- Molecular Formula
- C8H8ClNO2
- Formula Weight
- 185.61
- MOL File
- 211678-96-5.mol
3-CHLOROISONICOTINIC ACID ETHYL ESTER Property
- Boiling point:
- 250.2±20.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.91±0.18(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E940108
- Product name
- Ethyl3-Chloroisonicotinate
- Packaging
- 2.5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Y15337
- Product name
- 3-Chloropyridine-4-carboxylicacidethylester
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- Y15337
- Product name
- 3-Chloropyridine-4-carboxylicacidethylester
- Purity
- 98%
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR950143
- Product name
- 3-Chloropyridine-4-carboxylicacidethylester
- Purity
- 95%
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- HCH0012525
- Product name
- 3-CHLOROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.28
- Updated
- 2021/12/16
3-CHLOROISONICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
64-17-5
211678-96-5
General procedure for the synthesis of ethyl 3-chloroisonicotinate from ethanol: 3-chloroisonicotinate (1.0 g, 6.35 mmol) was suspended in thionyl chloride (10 ml) and heated to reflux for 2.5 hours. Upon completion of the reaction, the solution was cooled to room temperature, concentrated to dryness and subsequently azeotropized with toluene (10 ml) to give an oil. The resulting oily substance was slowly added dropwise to a cooled mixture of ethanol (15 ml) and diisopropylethylamine (DIPEA) at 0°C, the dropwise process was controlled to be completed within 10 minutes. The reaction mixture was stirred at room temperature for 18 hours. At the end of the reaction, the reaction solution was concentrated in vacuum, diluted with water (20 ml) and extracted with ethyl acetate (30 ml). The organic phase was dried over anhydrous sodium sulfate and concentrated to give ethyl 3-chloroisonicotinate as an orange oil (1.1 g, 94% yield). The product was characterized by 1H NMR (CDCl3, 400MHz): δ 8.72 (s, 1H), 8.59 (d, J = 4.9Hz, 1H), 7.63 (dd, J = 4.9Hz, 0.5Hz, 1H), 4.44 (q, J = 7.3Hz, 2H), 1.42 (t, J = 7.3Hz, 3H).
References
[1] Patent: WO2008/24724, 2008, A1. Location in patent: Page/Page column 68-69
3-CHLOROISONICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLOROISONICOTINIC ACID ETHYL ESTER Suppliers
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