Methyl 5-bromo-6-chloropyridine-3-carboxylate
- Product Name
- Methyl 5-bromo-6-chloropyridine-3-carboxylate
- CAS No.
- 78686-77-8
- Chemical Name
- Methyl 5-bromo-6-chloropyridine-3-carboxylate
- Synonyms
- Methyl 5-bromo-6-chl;METHYL 5-BROMO-6-CHLORONICOTINATE;5-Bromo-6-Chloro methyl nicotinate;Methyl-5-bromo-6-chloronicotinic acid;5-bromo-3-methoxy-1,2-dihydropyridin-2-one;5-BROMO-6-CHLORONICOTINIC ACID METHYL ESTER;Methyl 5-bromo-6-chloropyridin-3-carboxylate;methyl 5-bromo-6-chloropyridine-3-carboxylate;Methyl 3-bromo-2-chloropyridine-5-carboxylate;3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester
- CBNumber
- CB3148598
- Molecular Formula
- C7H5BrClNO2
- Formula Weight
- 250.48
- MOL File
- 78686-77-8.mol
Methyl 5-bromo-6-chloropyridine-3-carboxylate Property
- Melting point:
- 75-77°C
- Boiling point:
- 279.2±35.0 °C(Predicted)
- Density
- 1.684
- refractive index
- 1.568
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- -2.84±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C7H5BrClNO2/c1-12-7(11)4-2-5(8)6(9)10-3-4/h2-3H,1H3
- InChIKey
- WINGWVOUOFMOJQ-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(Br)C=C1C(OC)=O
- CAS DataBase Reference
- 78686-77-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M295945
- Product name
- Methyl5-bromo-6-chloronicotinate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M295945
- Product name
- Methyl5-bromo-6-chloronicotinate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 455683
- Product name
- Methyl 5-bromo-6-chloronicotinate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- M12647
- Product name
- Methyl5-bromo-6-chloronicotinate
- Purity
- 95%
- Packaging
- 1g
- Price
- $6
- Updated
- 2021/12/16
- Product number
- 045436
- Product name
- Methyl 5-bromo-6-chloronicotinate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
Methyl 5-bromo-6-chloropyridine-3-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 5-Bromo-6-chloronicotinate can be used to treat diseases related to S1PR1.
Synthesis
29241-62-1
74-88-4
78686-77-8
Step 1: Synthesis of methyl 5-bromo-6-chloronicotinate (61). A mixture of 5-bromo-6-chloronicotinic acid (60) (0.2 g, 0.84 mmol), potassium carbonate (K2CO3) (0.3 g, 2.1 mmol) and iodomethane (0.178 g, 1.2 mmol) in N,N-dimethylformamide (DMF) (10 mL) was stirred for 16 h at 0 °C and subsequently raised to room temperature. Upon completion of the reaction, the reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (EtOAc) (2 x 20 mL). The organic phases were combined and washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) (20 mL) and brine (2 x 20 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated to afford the target product methyl 5-bromo-6-chloronicotinate (61) (0.2 g, 94.7% yield).
References
[1] Patent: WO2017/4608, 2017, A1. Location in patent: Paragraph 0183
Methyl 5-bromo-6-chloropyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-bromo-6-chloropyridine-3-carboxylate manufacturers
- Product
- Methyl 5-bromo-6-chloronicotinate?? 78686-77-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- methyl 5-bromo-6-chloronicotinate 78686-77-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-18
- Product
- Methyl 5-bromo-6-chloropyridine-3-carboxylate 78686-77-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09