5-Bromo-6-methoxynicotinic acid methyl ester
- Product Name
- 5-Bromo-6-methoxynicotinic acid methyl ester
- CAS No.
- 93349-99-6
- Chemical Name
- 5-Bromo-6-methoxynicotinic acid methyl ester
- Synonyms
- Methyl 5-Bromo-6-methoxynicotinate;5-Bromo-6-methoxynicotinic acid methyl este;5-Bromo-6-methoxynicotinic acid methyl ester;methyl 5-bromo-6-methoxypyridine-3-carboxylate;5-bromo-6-methoxy-3-pyridinecarboxylic acid methyl ester;2-broMethyl 5-bromo-6-methoxynicotinatemocyclopentan-1-one;3-Pyridinecarboxylic acid, 5-bromo-6-methoxy-, methyl ester
- CBNumber
- CB12516254
- Molecular Formula
- C8H8BrNO3
- Formula Weight
- 246.06
- MOL File
- 93349-99-6.mol
5-Bromo-6-methoxynicotinic acid methyl ester Property
- Boiling point:
- 275℃
- Density
- 1.53
- Flash point:
- 120℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.99±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H8BrNO3/c1-12-7-6(9)3-5(4-10-7)8(11)13-2/h3-4H,1-2H3
- InChIKey
- UCOBYBCUAQNLBK-UHFFFAOYSA-N
- SMILES
- C1=NC(OC)=C(Br)C=C1C(OC)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M296545
- Product name
- Methyl5-Bromo-6-methoxynicotinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR313072
- Product name
- Methyl5-bromo-6-methoxynicotinate
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
- Product number
- 4H23-9-52
- Product name
- Methyl 5-bromo-6-methoxynicotinate
- Packaging
- 1g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- 5797AC
- Product name
- Methyl5-bromo-6-methoxynicotinate
- Packaging
- 5g
- Price
- $304
- Updated
- 2021/12/16
- Product number
- 5797AC
- Product name
- Methyl5-bromo-6-methoxynicotinate
- Packaging
- 10g
- Price
- $437
- Updated
- 2021/12/16
5-Bromo-6-methoxynicotinic acid methyl ester Chemical Properties,Usage,Production
Synthesis
1190862-68-0
124-41-4
93349-99-6
Step-1: Synthesis of methyl 5-bromo-6-methoxynicotinate: ethyl 5,6-dibromonicotinate (5.0 g, 16.2 mmol, 1.0 eq.) was dissolved in anhydrous methanol (5 mL) under the protection of nitrogen and sodium methanolate (2.18 g, 40.5 mmol, 2.5 eq.) was added slowly. The reaction mixture was transferred to a sealed tube and heated and stirred at 85 °C in an oil bath for 48 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The crude product was dissolved in water (20 mL) and extracted with ethyl acetate (50 mL) to separate the organic layer. The aqueous layer was extracted twice more with ethyl acetate (2 x 50mL). The organic layers were combined, washed with saturated saline (50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the crude product was purified by silica gel column chromatography (eluent: gradient elution of ethyl acetate/hexane) to obtain the target product 5-bromo-6-methoxynicotinic acid methyl ester in the form of a white solid of 1.55 g, yield 39%. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and ESI-MS: 1H NMR δ 8.76 (d, J = 2.0 Hz, 1H), 8.41 (d, J = 2.0 Hz, 1H), 4.09 (s, 3H), 3.93 (s, 3H); ESI-MS m/z 246, 248 [M+H]+.
References
[1] Patent: WO2013/164769, 2013, A1. Location in patent: Page/Page column 40-41
5-Bromo-6-methoxynicotinic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-6-methoxynicotinic acid methyl ester manufacturers
- Product
- 5-Bromo-6-methoxynicotinic acid methyl ester 93349-99-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09