5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid

Product Name: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid
CAS No.: 50593-92-5
Chemical Name: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid
Synonyms: 5-Bromo-2-(Methylsulfanyl)-4-P;5-BROMO-2-(METHYLTHIO)PYRIMIDINE-4-CARB&;5-Bromo-2-(methylthio)pyrimidine-carboxylic acid;5-BROMO-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLIC ACID;5-Bromo-2-(methylthio)-pyrimidin-4-carboxylic acid;5-Bromo-2-(Methylthio)-4-pyrimidine carboxylic acid;4-Pyrimidinecarboxylic acid, 5-bromo-2-(methylthio)-;5-BROMO-2-METHYLSULFANYL-PYRIMIDINE-4-CARBOXYLIC ACID;5-Bromo-2-(methylsulfanyl)-4-pyrimidine-carboxylicaci;5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLIC ACID
CBNumber: CB3187588
Molecular Formula: C6H5BrN2O2S
Formula Weight: 249.09
MOL File: 50593-92-5.mol

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5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid Property

Melting point:: 158-162 °C (dec.)
Boiling point:: 414.5±30.0 °C(Predicted)
Density: 1.91±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 1.31±0.10(Predicted)
Appearance: Light yellow to brown Solid
InChI: InChI=1S/C6H5BrN2O2S/c1-12-6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
InChIKey: YJEWVVYJOJJLBP-UHFFFAOYSA-N
SMILES: C1(SC)=NC=C(Br)C(C(O)=O)=N1
CAS DataBase Reference: 50593-92-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36/37-28
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 656739
Product name: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $47.7
Updated: 2023/01/07

TCI Chemical

Product number: B3829
Product name: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic Acid
Purity: >97.0%(T)
Packaging: 1g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: B3829
Product name: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic Acid
Purity: >97.0%(T)
Packaging: 5g
Price: $102
Updated: 2025/07/31

Usbiological

Product number: 295543
Product name: 5-Bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid
Packaging: 5g
Price: $432
Updated: 2021/12/16

TRC

Product number: B697833
Product name: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic Acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

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5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to yellow to light brown solid

Synthesis

488-11-9

867-44-7

50593-92-5

Mucobromic acid (58.05 g, 0.225 mol) was slowly added to a stirring aqueous solution (500 mL) of S-methylisothiourea sulfate (62.66 g, 0.225 mol) at room temperature. Subsequently, the reaction suspension was cooled to 10 °C (using an ice bath) and triethylamine (94.1 mL, 0.675 mol) was added dropwise over 4 hours. After the dropwise addition was completed, the reaction mixture was allowed to stand at room temperature for 24 hours. Upon completion of the reaction, activated carbon (Darco G-60) was added to the dark red/brown solution and the activated carbon was removed by filtration after stirring for 10 minutes. The filtrate was acidified with concentrated hydrochloric acid (50 mL) and the precipitated yellow precipitate was collected by filtration and washed sequentially with water (2 x 80 mL) and ether (2 x 100 mL). Finally, the product was dried in a vacuum oven at 50 °C for 2 days to afford 2-(methylthio)-5-bromo-4-pyrimidinecarboxylic acid (33.13 g, 59% yield) as a yellow amorphous solid.1H NMR (DMSO-d6, 400 MHz) δ: 2.75 (s, 3H), 9.20 (s, 1H).

References

[1] Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 2, p. 539 - 547
[2] Patent: WO2006/66172, 2006, A1. Location in patent: Page/Page column 50
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00283
[4] Patent: WO2014/99836, 2014, A1. Location in patent: Page/Page column 29; 30

5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Clindamycin palmitate hydrochloride Triethylamine 2-Methyl-2-thiopseudourea sulfate Mucobromic acid

Preparation Products

IFLAB-BB F2124-0045

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5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid Suppliers

Americas 1 Belgium 1 Canada 1 China 184 Europe 1 France 1 Germany 3 India 6 Japan 1 Russia 1 Switzerland 1 United Kingdom 6 United States 31 Global 238

R.R Scientific, LLC.

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View Lastest Price from 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 50593-92-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20 tons
Release date: 2025-07-23

R&D Scientific Inc.

Product: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 50593-92-5
Price: US $980.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 5000 Kg
Release date: 2025-03-04

Dideu Industries Group Limited

Product: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 50593-92-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acidRelated Search:

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5-Bromo-2-(methylthio)-pyrimidin-4-carboxylic acid

50593-92-5

59093-92-5

C6H5BrN2O2S

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

Heterocycle-Pyrimidine series

pharmacetical

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines

Heterocycle intermediates

Acids and Derivatives

Heterocycles

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks