METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97

Product Name: METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97
CAS No.: 50593-91-4
Chemical Name: METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97
Synonyms: fanyL;)-4- pyrimidinecarboxyL;Methyl 5-BroMo-2-(Methylthio)-4-pyriMidinecarboxylate;methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate;Methyl 5-bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylate;methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate;Methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate ,97%;THYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97;METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97;4-PyriMidinecarboxylic acid, 5-broMo-2-(Methylthio)-, Methyl ester
CBNumber: CB4506636
Molecular Formula: C7H7BrN2O2S
Formula Weight: 263.11
MOL File: 50593-91-4.mol

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METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 Property

Melting point:: 67 °C
Boiling point:: 348.7±22.0 °C(Predicted)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -2.91±0.29(Predicted)
form: Solid
color: Pale yellow
Water Solubility: Slightly soluble in water (0.42 g/L).
InChI: InChI=1S/C7H7BrN2O2S/c1-12-6(11)5-4(8)3-9-7(10-5)13-2/h3H,1-2H3
InChIKey: MYZJIEWTRJTWCD-UHFFFAOYSA-N
SMILES: C1(SC)=NC=C(Br)C(C(OC)=O)=N1

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Safety

Hazard Codes: Xi
Risk Statements: 43-36/37/38-20/21/22
Safety Statements: 36/37-36/37/39-26-22
RIDADR: UN2811
HazardClass: IRRITANT
HazardClass: 6.1
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 8H66-9-20
Product name: Methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate
Purity: 97.0%
Packaging: 250mg
Price: $62
Updated: 2021/12/16

Matrix Scientific

Product number: 046407
Product name: Methyl 5-bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylate
Purity: >95%
Packaging: 500mg
Price: $68
Updated: 2021/12/16

Matrix Scientific

Product number: 046407
Product name: Methyl 5-bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylate
Purity: >95%
Packaging: 1g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: W6585
Product name: Methyl5-bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylate
Packaging: 5g
Price: $104
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H66-9-20
Product name: Methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate
Purity: 97.0%
Packaging: 1g
Price: $105
Updated: 2021/12/16

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METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

It can be used as pharmaceutical raw material and intermediate.

Synthesis

67-56-1

50593-92-5

50593-91-4

General procedure for the preparation of methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate: 5-bromo-2-(methylthio)pyrimidine-4-carboxylic acid (7.64 g, 30.7 mmol) was dissolved in methanol (60 mL). Sulfuric acid (2 mL) was added to the solution and the mixture was subsequently heated to reflux for 24 hours. Upon completion of the reaction, the mixture was poured into ice water and extracted with dichloromethane (DCM). The organic phase was washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate (6.42 g, 80% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 8.72 (s, 1H), 4.01 (s, 3H), 2.58 (s, 3H).LCMS (ESI) analysis showed a retention time of Rt = 2.35 min and a molecular ion peak 263 [M + H]+.

References

[1] Patent: WO2014/37750, 2014, A1. Location in patent: Paragraph 00149; 0046-0050
[2] Patent: WO2015/128676, 2015, A1. Location in patent: Page/Page column 117-118
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2215 - 2226
[4] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00284
[5] Patent: EP3305785, 2018, A1. Location in patent: Paragraph 0167; 0168

METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Clindamycin palmitate hydrochloride Sodium chloride Triethylamine 2-Methyl-2-thiopseudourea sulfate Methanol Mucobromic acid Sulfuric acid

Preparation Products

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METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 Suppliers

Belgium 1 China 83 Germany 2 India 1 United Kingdom 1 United States 12 Global 100

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View Lastest Price from METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 manufacturers

Dideu Industries Group Limited

Product: METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 50593-91-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Career Henan Chemical Co

Product: METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 50593-91-4
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-09

50593-91-4, METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97Related Search:

PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER 5-Bromopyrimidine 5-BROMO-4-PYRIMIDINECARBOXALDEHYDE 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 5-BROMO-2-(METHYLTHIO)PYRIMIDINE 2-Thiomethylpyrimidine-4-carboxylic acid METHYL 5-BROMO-4-PYRIMIDINECARBOXYLATE METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 5-BROMO-4-PYRIMIDINECARBOXYLIC ACID

5-Bromo-2-(methylsulfanyl)pyrimidine-4-carboxylic acid methyl ester

methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate

Methyl 5-bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylate

METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97

Methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate ,97%

methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate

Methyl 5-BroMo-2-(Methylthio)-4-pyriMidinecarboxylate

THYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97

4-PyriMidinecarboxylic acid, 5-broMo-2-(Methylthio)-, Methyl ester

)-4- pyrimidinecarboxyL

fanyL

METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 ISO 9001：2015 REACH

50593-91-4

C7H7BrN2O2S

Heterocycle-Pyrimidine series