2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE

Product Name: 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE
CAS No.: 1074-68-6
Chemical Name: 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE
Synonyms: 2-(Methylthio)pyrimidine-4-carbaldehyde;4-ForMyl-2-MethylthiopyriMidine;2-(Methylthio)pyridine-4-carbaldehyde;2-(Methylthio)-4-pyrimidinecarbaldehyde;2-Methylthiopyrimidine-4-carboxaldehyde;2-MethylsulfanylpyriMidin-4-carbaldehyde;2-(Methylthio)-4-pyrimidinecarboxaldehyde;2-METHYLTHIO-4-PYRIMIDINE CARBOXYALDEHYDE;2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE;2-Methylthio-4-pyrimidine carboxzyaldehyde
CBNumber: CB2384412
Molecular Formula: C6H6N2OS
Formula Weight: 154.19
MOL File: 1074-68-6.mol

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2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Property

Melting point:: 68°C
Boiling point:: 110-112 °C(Press: 0.001 Torr)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.87±0.23(Predicted)
form: solid
color: Off-white

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Safety

Safety Statements: 24/25
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F700805
Product name: 4-Formyl-2-methylthiopyrimidine
Packaging: 1g
Price: $140
Updated: 2021/12/16

AK Scientific

Product number: X8840
Product name: 2-Methylsulfanylpyrimidine-4-carbaldehyde
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Apolloscientific

Product number: OR907027
Product name: 2-(Methylthio)pyrimidine-4-carbaldehyde
Purity: 95%
Packaging: 250mg
Price: $170
Updated: 2021/12/16

Matrix Scientific

Product number: 072119
Product name: 2-Methylsulfanylpyrimidine-4-carbaldehyde
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

Apolloscientific

Product number: OR907027
Product name: 2-(Methylthio)pyrimidine-4-carbaldehyde
Purity: 95%
Packaging: 1g
Price: $420
Updated: 2021/12/16

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2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Chemical Properties,Usage,Production

Uses

4-Formyl-2-methylthiopyrimidine is used in the synthesis of cytokine synthesis inhibitors.

Synthesis

180869-36-7

1074-68-6

Example 4 Synthesis of 2-(methylthio)pyrimidine-4-carboxaldehyde (4): 4-(dimethoxymethyl)-2-(methylthio)pyrimidine (3) (53.7 g, 268 mmol) was slowly added to an aqueous solution of 1.2N HCl (300 mL, 268 mmol, 1.0 eq.) at 60 °C with continuous stirring for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and neutralized by slow addition of solid sodium bicarbonate. Subsequently, the crude product was extracted with ether (3 x 150 mL) and the combined organic layers were concentrated under reduced pressure to afford the target product 2-(methylthio)pyrimidine-4-carboxaldehyde (4) as a yellow solid (14.2 g, 34% yield).LC-MS m/z 155 (M+1). Reference: WO 2006/009734 A1, p. 67.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 3, p. 1067 - 1088
[2] Patent: WO2016/7966, 2016, A2. Location in patent: Paragraph 0024
[3] Journal of Medicinal Chemistry, 2018,
[4] Patent: US2011/152235, 2011, A1. Location in patent: Page/Page column 67
[5] Patent: WO2011/103289, 2011, A2. Location in patent: Page/Page column 73; 74

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Suppliers

China 131 Germany 3 India 2 United States 12 Global 148

J & K SCIENTIFIC LTD.

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View Lastest Price from 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Methylsulfanylpyrimidine-4-carbaldehyde 1074-68-6
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Dideu Industries Group Limited

Product: 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 1074-68-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-14

Career Henan Chemical Co

Product: 2-Methylsulfanylpyrimidine-4-carbaldehyde 1074-68-6
Price: US $1.00/KG
Min. Order: 1g
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-09

1074-68-6, 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDERelated Search:

METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 2-Methylsulfanyl-pyrimidine-5-carbaldehyde ,95%,2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE PYRIMIDINE-4-CARBOXALDEHYDE IFLAB-BB F2124-0044 2-PROPYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 2-ISOPROPYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 6-Hydroxy-2-(methylsulfanyl)-4-pyrimidinecarboxylic acid METHYL 6-METHYL-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE AKOS BBS-00001671 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 4-AMINO-6-CHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE AKOS BBS-00001669 5,6-DIMETHOXY-2-METHYLSULFANYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER

2-Methylthiopyrimidine-4-carboxaldehyde

2-Methylthio-4-pyrimidine carboxzyaldehyde

2-METHYLTHIO-4-PYRIMIDINE CARBOXYALDEHYDE

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE

2-(Methylthio)pyrimidine-4-carbaldehyde

2-MethylsulfanylpyriMidin-4-carbaldehyde

4-ForMyl-2-MethylthiopyriMidine

2-(Methylthio)pyridine-4-carbaldehyde

4-PyriMidinecarboxaldehyde, 2-(Methylthio)-

2-(Methylthio)-4-pyrimidinecarbaldehyde

2-(Methylthio)-4-pyrimidinecarboxaldehyde

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE ISO 9001：2015 REACH

1074-68-6

1074-68-8

Heterocycle-Pyrimidine series

Pyrimidine series