4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
- Product Name
- 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
- CAS No.
- 185040-32-8
- Chemical Name
- 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
- Synonyms
- 4-MethylaMino-2-MethylsulfanylpyriMidine;4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxald;4-MethylaMino-2-MethanethiopyriMidine-5- carboxaldehyde;4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde;4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE;4-(METHYLAMINO)-2-(METHYLTHIO)-5-PYRIMIDINE CARBALDEHYDE;4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde;4-(MethylaMino)-2-(Methylthio)-5-pyriMidinecarboxaldehyde;4-MethylaMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde;5-Pyrimidinecarboxaldehyde, 4-(methylamino)-2-(methylthio)-
- CBNumber
- CB9147139
- Molecular Formula
- C7H9N3OS
- Formula Weight
- 183.23
- MOL File
- 185040-32-8.mol
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Property
- Melting point:
- 99-101 °C
- Boiling point:
- 377.1±27.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
- form
- Solid
- pka
- 3.15±0.10(Predicted)
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M286915
- Product name
- 4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde
- Packaging
- 5g
- Price
- $760
- Updated
- 2021/12/16
- Product number
- 076561
- Product name
- 4-(Methylamino)-2-(methylthio)-pyrimidine-5-carbaldehyde
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $278
- Updated
- 2021/12/16
- Product number
- 076561
- Product name
- 4-(Methylamino)-2-(methylthio)-pyrimidine-5-carbaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $599
- Updated
- 2021/12/16
- Product number
- CHM0068932
- Product name
- 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- W4000
- Product name
- 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
- Packaging
- 10g
- Price
- $888
- Updated
- 2021/12/16
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Intermediate in the preparation of p38 kinase inhibitors
Synthesis
17759-30-7
185040-32-8
In a dry 3L three-necked round-bottomed flask equipped with an overhead mechanical stirrer and an argon inlet, 32.74 g (176.7 mmol) of (4-methylamino-2-methanesulfonyl-pyrimidin-5-yl)-methanol was dissolved in 1.6 L of chloroform. Under stirring conditions, 152 g (1.75 mol) of manganese dioxide was added in batches. The reaction mixture was slightly heated and stirred continuously for 7 hours. Upon completion of the reaction, vacuum filtration was performed through a diatomaceous earth pad to remove the manganese dioxide and the filter cake was washed well with two 300mL portions of chloroform. The filtrates were combined and concentrated to give a white solid product. After vacuum drying, 30.6 g (94% yield) of 4-methylamino-2-methylthio-5-formylpyrimidine was obtained. The spectral data of the obtained product were in agreement with the values reported in the literature.
References
[1] Patent: WO2004/63195, 2004, A1. Location in patent: Page 53-54
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 17, p. 3276 - 3292
[3] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 355
[4] Patent: WO2008/33999, 2008, A2. Location in patent: Page/Page column 88
[5] Patent: WO2014/11900, 2014, A2. Location in patent: Page/Page column 31; 32
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Suppliers
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View Lastest Price from 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE manufacturers
- Product
- 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 185040-32-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-15
- Product
- 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 185040-32-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25