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4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE

Product Name
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
CAS No.
185040-32-8
Chemical Name
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
Synonyms
4-MethylaMino-2-MethylsulfanylpyriMidine;4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxald;4-MethylaMino-2-MethanethiopyriMidine-5- carboxaldehyde;4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde;4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE;4-(METHYLAMINO)-2-(METHYLTHIO)-5-PYRIMIDINE CARBALDEHYDE;4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde;4-(MethylaMino)-2-(Methylthio)-5-pyriMidinecarboxaldehyde;4-MethylaMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde;5-Pyrimidinecarboxaldehyde, 4-(methylamino)-2-(methylthio)-
CBNumber
CB9147139
Molecular Formula
C7H9N3OS
Formula Weight
183.23
MOL File
185040-32-8.mol
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4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Property

Melting point:
99-101 °C
Boiling point:
377.1±27.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
form 
Solid
pka
3.15±0.10(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M286915
Product name
4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde
Packaging
5g
Price
$760
Updated
2021/12/16
AK Scientific
Product number
W4000
Product name
4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
Packaging
10g
Price
$888
Updated
2021/12/16
Matrix Scientific
Product number
076561
Product name
4-(Methylamino)-2-(methylthio)-pyrimidine-5-carbaldehyde
Purity
95+%
Packaging
1g
Price
$599
Updated
2021/12/16
Matrix Scientific
Product number
076561
Product name
4-(Methylamino)-2-(methylthio)-pyrimidine-5-carbaldehyde
Purity
95+%
Packaging
5g
Price
$1607
Updated
2021/12/16
AK Scientific
Product number
W4000
Product name
4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
Packaging
25g
Price
$1705
Updated
2021/12/16
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4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Intermediate in the preparation of p38 kinase inhibitors

Synthesis

17759-30-7

185040-32-8

In a dry 3L three-necked round-bottomed flask equipped with an overhead mechanical stirrer and an argon inlet, 32.74 g (176.7 mmol) of (4-methylamino-2-methanesulfonyl-pyrimidin-5-yl)-methanol was dissolved in 1.6 L of chloroform. Under stirring conditions, 152 g (1.75 mol) of manganese dioxide was added in batches. The reaction mixture was slightly heated and stirred continuously for 7 hours. Upon completion of the reaction, vacuum filtration was performed through a diatomaceous earth pad to remove the manganese dioxide and the filter cake was washed well with two 300mL portions of chloroform. The filtrates were combined and concentrated to give a white solid product. After vacuum drying, 30.6 g (94% yield) of 4-methylamino-2-methylthio-5-formylpyrimidine was obtained. The spectral data of the obtained product were in agreement with the values reported in the literature.

References

[1] Patent: WO2004/63195, 2004, A1. Location in patent: Page 53-54
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 17, p. 3276 - 3292
[3] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 355
[4] Patent: WO2008/33999, 2008, A2. Location in patent: Page/Page column 88
[5] Patent: WO2014/11900, 2014, A2. Location in patent: Page/Page column 31; 32

4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Suppliers

Canada 1 China 81 India 2 Switzerland 2 United Kingdom 1 United States 12 Global 99
Achemica
Tel
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Email
contact@achemica.com
Country
Switzerland
ProdList
6155
Advantage
50
Biosynth AG
Tel
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Fax
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Email
welcome@biosynth.ch
Country
Switzerland
ProdList
3324
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View Lastest Price from 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE manufacturers

Dideu Industries Group Limited
Product
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 185040-32-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-15
Career Henan Chemical Co
Product
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 185040-32-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-25

185040-32-8, 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDERelated Search:

2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE ETHYL 2-(METHYLSULFANYL)-4-PIPERIDINO-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-MORPHOLINO-5-PYRIMIDINECARBOXYLATE ETHYL 4-(3,4-DICHLOROANILINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-(1-PYRROLIDINYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(4-CHLOROANILINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(BENZYLAMINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE BUTTPARK 21\09-28 ETHYL 4-[3,5-BIS(TRIFLUOROMETHYL)ANILINO]-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-[4-(2-FLUOROPHENYL)PIPERAZINO]-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-[4-(TRIFLUOROMETHYL)ANILINO]-5-PYRIMIDINECARBOXYLATE BUTTPARK 21\09-24 ETHYL 4-[2-CHLORO-5-(TRIFLUOROMETHYL)ANILINO]-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(ALLYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-[4-(TRIFLUOROMETHOXY)ANILINO]-5-PYRIMIDINECARBOXYLATE ETHYL 4-[(2-METHOXYETHYL)AMINO]-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE BUTTPARK 21\09-21

  • 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
  • 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
  • 4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde
  • 5-Pyrimidinecarboxaldehyde, 4-(methylamino)-2-(methylthio)-
  • 4-MethylaMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde
  • 4-MethylaMino-2-MethylsulfanylpyriMidine
  • 4-(MethylaMino)-2-(Met hylsulfanyl)pyriMidine-5-carboxaldehyde
  • 4-(MethylaMino)-2-(Methylthio)-5-pyriMidinecarboxaldehyde
  • 4-MethylaMino-2-MethanethiopyriMidine-5- carboxaldehyde
  • 4-(METHYLAMINO)-2-(METHYLTHIO)-5-PYRIMIDINE CARBALDEHYDE
  • 4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxald
  • 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH
  • 185040-32-8
  • C7H9N3OS
  • Building Blocks
  • Pyrimidine
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Heterocycle-Pyrimidine series