5-Bromopyrimidine

Product Name: 5-Bromopyrimidine
CAS No.: 4595-59-9
Chemical Name: 5-Bromopyrimidine
Synonyms: 5-bromo-pyrimidin;5-pyriMidine;5-Brompyrimidin;5-BROMOPYRIMIDINE;5-Bromo-1,3-diazine;PYRIMIDINE, 5-BROMO-;PYRIMIDINE, 2-BROMO-;5-Bromopyrimidine,98%;5-Bromopyrimidine >5-BROMOPYRIMIDINE 0.98
CBNumber: CB8853640
Molecular Formula: C4H3BrN2
Formula Weight: 158.98
MOL File: 4595-59-9.mol

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5-Bromopyrimidine Property

Melting point:: 67-73 °C (lit.)
Boiling point:: 168°C(lit.)
Density: 1.6448 (rough estimate)
refractive index: 1.5260 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in chloroform.
form: Crystalline Powder or Chunks
pka: 1.40±0.10(Predicted)
color: Yellow to beige-brown
BRN: 107326
InChI: InChI=1S/C4H3BrN2/c5-4-1-6-3-7-2-4/h1-3H
InChIKey: GYCPLYCTMDTEPU-UHFFFAOYSA-N
SMILES: C1=NC=C(Br)C=N1
CAS DataBase Reference: 4595-59-9(CAS DataBase Reference)
NIST Chemistry Reference: Pyrimidine, 5-bromo-(4595-59-9)
EPA Substance Registry System: Pyrimidine, 5-bromo- (4595-59-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
TSCA: TSCA listed
HazardClass: IRRITANT, KEEP COLD
HS Code: 29335990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219142
Product name: 5-Bromopyrimidine
Purity: 97%
Packaging: 5g
Price: $40.41
Updated: 2025/07/31

Sigma-Aldrich

Product number: 219142
Product name: 5-Bromopyrimidine
Purity: 97%
Packaging: 25g
Price: $87.9
Updated: 2025/07/31

TCI Chemical

Product number: B2229
Product name: 5-Bromopyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: B2229
Product name: 5-Bromopyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $288
Updated: 2025/07/31

TRC

Product number: B686855
Product name: 5-Bromopyrimidine
Packaging: 5g
Price: $50
Updated: 2021/12/16

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5-Bromopyrimidine Chemical Properties,Usage,Production

Description

5-Bromopyrimidine is an important structural unit in organic compounds, featuring a bromine functional group on its pyrimidine ring which serves as the active moiety enabling participation in diverse chemical reactions. Through acid-catalysed electrophilic alkylation of aromatic compounds with 5-bromopyrimidine, followed by oxidative rearrangement to form the dihydropyrimidine ring. Subsequent Sonogashira cross-coupling enables the preparation of 4-aryl-5-pyrimidylacetylene derivatives, which possess medicinal value.

Chemical Properties

yellow solid crystalline, insoluble in water, soluble in organic solvents such as benzene and toluene.

Uses

5-Bromopyrimidine was used in the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction, (5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol.

Uses

5-Bromopyrimidine was used in the synthesis of:
N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction
(5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol
Intermediate for the synthesis of plant growth regulator flurprimidol

Application

5-Bromopyrimidine is a compound useful in organic synthesis.

Preparation

5-Bromopyrimidine is prepared by reacting dibromodifuranone with formamide in the presence of B2O2 catalyst at 180-185°C to obtain the product.

General Description

Rapid nucleophilic displacement reactions of 5-bromopyrimidine with nucleophiles under microwave irradiation has been studied. 5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine.

5-Bromopyrimidine Preparation Products And Raw materials

Raw materials

2,3-Dihydrofuran 4-Hydroxy-2,5-dimethyl-3(2H)furanone

Preparation Products

5-HYDROXYPYRIMIDINE 5-Pyrimidinecarboxylic acid 5-Pyrimidinylboronic acid Pyrimidine-5-carboxaldehyde 5-Hydroxypyrimidine

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5-Bromopyrimidine Suppliers

Americas 1 Belgium 3 Canada 3 China 415 Europe 5 Germany 6 India 24 Japan 6 Slovakia 1 South Korea 1 Switzerland 5 The Netherlands 2 Ukraine 1 United Kingdom 19 United States 69 Global 561

Suzhou Qiushuo Biotechnology Co., Ltd

Tel: 0512-67862615 13382151840
Email: 2943249291@QQ.COM
Country: China
ProdList: 342
Advantage: 58

Suzhou Xinrui Biotechnology Co., Ltd.

Tel: 13401437572
Email: xinruibiotech01@163.com
Country: China
ProdList: 2741
Advantage: 58

Changzhow Moisten International Trading Co., Ltd.

Tel: 13606112397
Email: tang13606112397@163.com
Country: China
ProdList: 191
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 037155153829 18003835034
Email: 3897192574@qq.com
Country: China
ProdList: 9988
Advantage: 58

Dream Chemical (Tianjin) Co., Ltd

Tel: 17602663561
Email: public@dreamchem.cn
Country: China
ProdList: 993
Advantage: 58

Shandong Yiren Pharmaceutical Co. LTD

Tel: 531-87922518 15628888630
Email: 1029084569@qq.com
Country: China
ProdList: 362
Advantage: 58

Suzhou Vosun Biotech Co.,Ltd

Tel: 18934576691 18934576691;
Fax: 0512-82177265
Email: yq@vosunbio.com
Country: China
ProdList: 740
Advantage: 58

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd

Tel: 027-83855310 13476018176
Fax: 13476018176
Email: 408614617@qq.com
Country: China
ProdList: 998
Advantage: 58

Hubei Koma Biotechnology Co., Ltd.

Tel: 15549418308
Email: 345969539@qq.com
Country: China
ProdList: 191
Advantage: 58

SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
Fax: 0838-5675535
Email: nbcxkj@126.com
Country: China
ProdList: 937
Advantage: 55

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View Lastest Price from 5-Bromopyrimidine manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: 5-Bromopyrimidine 4595-59-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Bromopyrimidine 4595-59-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 100kg
Release date: 2023-01-13

Zhengzhou Alfa Chemical Co.,Ltd

Product: 5-Bromopyrimidine 4595-59-9
Price: US $238.00/g
Min. Order: 1g
Purity: 97% min.
Supply Ability: 300kg
Release date: 2021-03-26

4595-59-9, 5-BromopyrimidineRelated Search:

5-Bromo-2,4-dichloropyrimidine Fluorocytosine Alloxan Pyrimethamine Cytosine Silver sulfadiazine Sulfadiazine Pyrimidine Uracil 5-Bromophthalide 5-Bromonicotinic acid 5-Bromoindole 2-AMINO-5-BROMOPYRIMIDINE,2-Amino-5-bromopyrimidine ,98% 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE 5-Bromo-4,6-dichloropyrimidine 2-Amino-5-bromo-4,6-dimethylpyrimidine 5-Bromo-4,6-dihydroxypyrimidine 5-BROMO-2,4-DIMETHOXYPYRIMIDINE

5-bromo-pyrimidin

PYRIMIDINE, 2-BROMO-

PYRIMIDINE, 5-BROMO-

5-BROMOPYRIMIDINE

5-Bromopyrimidine,98%

Pyrimidine,5-bromo-(6CI,7CI,8CI,9CI)

5-BROMOISATINIC ANHYDRIDE

5-BROMOPYRIMIDINE, 99% MIN

5-BROMOPYRIMIDINE 0.98

5-BroMopyriMidine, 98% 25GR

5-pyriMidine

5-Bromo-1,3-diazine

5-BroMopyriMidine, 97+%

5 - broMine pyriMidine

5-Bromopyrimidine Vetec(TM) reagent grade, 97%

5-Bromopyrimidine &gt

27540 5-Bromopyrimidine

5-BROMOPYRIMIDINE 4595-59-9

5-Bromopyrimidine ISO 9001：2015 REACH

5-Brompyrimidin

5-Bromopyrimidine, 96%

4595-59-9

4595-59-5

C4H3BrN2

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

Halides

Pyrazines, Pyrimidines & Pyridazines

Aromatics Compounds

Aromatics

Heterocycles

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Pyrimidine

Heterocycle-Pyrimidine series

HALIDE

Pyridines, Pyrimidines, Purines and Pteredines

bc0001

4595-59-9