5-Bromo-2,4-dichloropyrimidine

Product Name: 5-Bromo-2,4-dichloropyrimidine
CAS No.: 36082-50-5
Chemical Name: 5-Bromo-2,4-dichloropyrimidine
Synonyms: NSC 152517;5-Bromo-2,4-dichL;BUTTPARK 48\06-22;TIMTEC-BB SBB003301;Xylose Impurity 3-d1;Palbociclib Impurity 99;2,4-Dichloro-5-Bromouracil;5-Bromo-2,4-dichloropyrdmidine;2,4-Dichloro-5-bormopyrimidine;5-BROMO-2,4-DICHLOROPYRIMIDINE
CBNumber: CB2739049
Molecular Formula: C4HBrCl2N2
Formula Weight: 227.87
MOL File: 36082-50-5.mol

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5-Bromo-2,4-dichloropyrimidine Property

Melting point:: 29-30 °C (lit.)
Boiling point:: 128 °C/15 mmHg (lit.)
Density: 1.781 g/mL at 25 °C (lit.)
refractive index: n20/D 1.603(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Ether (Slightly), Ethyl Acetate (Slightly), Toluene (Slightly)
form: Liquid or Low Melting Solid
pka: -4.26±0.29(Predicted)
Specific Gravity: 1.781
color: Clear colorless to light yellow
BRN: 124441
InChI: InChI=1S/C4HBrCl2N2/c5-2-1-8-4(7)9-3(2)6/h1H
InChIKey: SIKXIUWKPGWBBF-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Br)C(Cl)=N1
CAS DataBase Reference: 36082-50-5(CAS DataBase Reference)

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Safety

Hazard Codes: T,C
Risk Statements: 23/24/25-34-43
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3263 8/PG 2
WGK Germany: 3
Hazard Note: Toxic/Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 416762
Product name: 5-Bromo-2,4-dichloropyrimidine
Purity: 97%
Packaging: 5g
Price: $74.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 416762
Product name: 5-Bromo-2,4-dichloropyrimidine
Purity: 97%
Packaging: 25g
Price: $144
Updated: 2025/07/31

TCI Chemical

Product number: B2823
Product name: 5-Bromo-2,4-dichloropyrimidine
Purity: >97.0%(GC)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: B2823
Product name: 5-Bromo-2,4-dichloropyrimidine
Purity: >97.0%(GC)
Packaging: 25g
Price: $74
Updated: 2025/07/31

TRC

Product number: D433775
Product name: 2,4-Dichloro-5-bromopyrimidine
Packaging: 5g
Price: $90
Updated: 2021/12/16

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5-Bromo-2,4-dichloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

Colourless Oil

Uses

Starting material for the synthesis of trisubstituted pyrimidines via a combination of nucleophilic substitution and palladium-catalyzed aryl cross-coupling.1

Uses

5-Bromo-2,4-dichloropyrimidine may be employed as starting reagent for the synthesis of positive allosteric modulators for GABA_B receptors (drug-like class of compounds) and pyridinepyrimidine analogs.

General Description

5-Bromo-2,4-dichloropyrimidine is a halogenoprimidine. It has been reported as an intermediate during the synthesis of 2,4-di-t-butoxy-5-bromopyrimidine and 2,4-di-t-butoxy-5-pyrimidineboronic acid.

Synthesis

51-20-7

36082-50-5

General procedure for the synthesis of 5-bromo-2,4-dichloropyrimidine from 5-bromouracil: 5-bromouracil (6.0 g, 31.4 mmol) was placed in a reaction flask with phosphorus pentachloride (PCl5, 16.4 g, 87.9 mmol) and 1,1,2-trichloroethane (50 mL) was added as solvent. The reaction mixture was heated to reflux and the transformation of the mixture from suspension to a light yellow transparent solution was observed. The reaction progress was monitored by thin layer chromatography (TLC) and after confirming the complete conversion of the feedstock, the reaction mixture was cooled to room temperature. Subsequently, the reaction mixture was rapidly poured into stirred ice water and stirring was continued for 1 hour. The aqueous phase was extracted with dichloromethane (DCM, 3 x 50 mL), the organic layers were combined and dried with anhydrous magnesium sulfate (MgSO4). The solvent was removed by evaporation under reduced pressure to give a light yellow transparent liquid crude product. Finally, the crude product was purified by silica gel column chromatography to obtain the target compound 5-bromo-2,4-dichloropyrimidine as a colorless transparent liquid (99.5% yield, 97% purity).

References

[1] Patent: CN108117523, 2018, A. Location in patent: Paragraph 0039; 0041; 0043; 0044; 0045
[2] Purinergic Signalling, 2017, vol. 13, # 1, p. 89 - 103
[3] Patent: CN105237483, 2016, A. Location in patent: Paragraph 0039; 0040; 0041; 0042; 0043
[4] Patent: US4299961, 1981, A
[5] Journal of the American Chemical Society, 1934, vol. 56, p. 134,138

5-Bromo-2,4-dichloropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

4-Amino-5-bromo-2-chloropyrimidine 4-BENZYLOXY-5-BROMO-2-CHLOROPYRIMIDINE 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE 5-BROMO-2-CHLORO-4-(DIMETHYLAMINO)PYRIMIDINE 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE

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5-Bromo-2,4-dichloropyrimidine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 467 Europe 3 France 1 Germany 6 India 25 Japan 1 Poland 1 Russia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 20 United States 60 Global 594

China Shenyang Tyschem CO. ,LTD

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ELION INTERNATIONAL(HONGKONG) CO., LTD

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Hefei Qianhang Pharmaceutical Technology Co., Ltd.

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Fuxin Custchem Fine Chemical Co., Ltd.

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Lianhe Aigen Pharmatech Co.,Ltd.

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J & K SCIENTIFIC LTD.

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View Lastest Price from 5-Bromo-2,4-dichloropyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromo-2,4-dichloropyrimidine 36082-50-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-06-04

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Bromo-2,4-dichloropyrimidine 36082-50-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

AstaTech(Chengdu) Biopharmaceutical Corp.

Product: 5-Bromo-2,4-dichloropyrimidine 36082-50-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%min
Supply Ability: 20-40tons/year
Release date: 2022-01-10

36082-50-5, 5-Bromo-2,4-dichloropyrimidineRelated Search:

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BUTTPARK 48\06-22

5-BROMO-2,4-DICHLOROPYRIMIDINE

TIMTEC-BB SBB003301

5-Bromo-2,4-Dichloropyridimidine

5-BROMO-2,4-DICHLOROPYRIMIDINE 99%

2,4-DICHLORO-5-BROMO PYRIMIDINE

5-Bromo-2,4-dichL

5-Bromo-2,4-dichloropyrimidine ,97%

5-Bromo-2,4-dichloropyrimidine,98%

2,4-Dichloro-5-bormopyrimidine

5-Bromo-2,4-dichloropyrdmidine

2,4-Dichloro-5-broMopyriMidine See B684030

5-BroMo-2,6-dichloropyriMidine

NSC 152517

5-BroMo-2,4-dichloropyriMidine See D433775

2,6-Dichloro-5-broMopyriMidine

5-Bromo-2,4-dichloro-1,3-diazine

5-broMo -2,4-two chloropyriMidine

Pyrimidine, 5-bromo-2,4-dichloro-

5 - broMine - 2, 4 - dichloro pyriMidine

5-Bromo-2,4-dichloropyrimidine &gt

Palbociclib Impurity 99

5-Bromo-2,4-dichloropyrimidine,36082-50-5

2,4-Dichloro-5-Bromouracil

5-Bromo-2,4-dichloropyrimidine (98.65%)

5-Bromo-2,4-Dichlor Pyrimidine

Xylose Impurity 3-d1

36082-50-5

30682-50-5

366082-50-5

C4HBrCl2N2

C4HBrCI2N2

C4HN2BrCl2

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

HALOGEN

Building Blocks

C4 to C5

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocycle-Pyrimidine series

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

pharmacetical

Halides

Pyrazines, Pyrimidines & Pyridazines

Pyrimidine

Pyrimidine Series

Pyridines, Pyrimidines, Purines and Pteredines

Halogenated

Organohalides

Nucleotides and Nucleosides

Aromatics Compounds

Bases & Related Reagents