5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE

Product Name: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE
CAS No.: 57054-92-9
Chemical Name: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE
Synonyms: 5-BroMo-2-chloro-4-Methox...;5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE;2-chloro-5-broMo-4-MethoxypyriMidine;Pyrimidine, 5-bromo-2-chloro-4-methoxy-;5-Bromo-2-chloro-4-methoxypyrimidine, >=98%;5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH;5-Bromo-2-chloro-4-methoxy-1,3-diazine, 5-Bromo-2-chloropyrimidin-4-yl methyl ether
CBNumber: CB7167984
Molecular Formula: C5H4BrClN2O
Formula Weight: 223.46
MOL File: 57054-92-9.mol

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5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE Property

Melting point:: 73-75 °C(Solv: hexane (110-54-3))
Boiling point:: 323.6±22.0 °C(Predicted)
Density: 1.745±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml; Ethanol: 15 mg/ml
form: A crystalline solid
pka: -1.35±0.29(Predicted)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21862
Product name: 5-bromo-2-chloro-4-Methoxypyrimidine
Purity: ≥98%
Packaging: 5g
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 21862
Product name: 5-bromo-2-chloro-4-Methoxypyrimidine
Purity: ≥98%
Packaging: 10 g
Price: $54
Updated: 2024/03/01

Cayman Chemical

Product number: 21862
Product name: 5-bromo-2-chloro-4-Methoxypyrimidine
Purity: ≥98%
Packaging: 25 g
Price: $119
Updated: 2024/03/01

Cayman Chemical

Product number: 21862
Product name: 5-bromo-2-chloro-4-Methoxypyrimidine
Purity: ≥98%
Packaging: 1g
Price: $77
Updated: 2023/01/06

TRC

Product number: B690418
Product name: 5-Bromo-2-chloro-4-methoxypyrimidine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE Chemical Properties,Usage,Production

Description

5-bromo-2-chloro-4-Methoxypyrimidine is a building block used in the chemical synthesis of halogenated heterocycles.

Uses

5-Bromo-2-chloro-4-methoxypyrimidine is a building block in the chemical synthesis.

Synthesis

36082-50-5

124-41-4

57054-92-9

To a stirred solution of 5-bromo-2,4-dichloropyrimidine (500 mg, 2.19 mmol) in methanol (5 mL) was slowly added 30% sodium methanol solution (0.40 mL, 2.26 mmol). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure. The residue was dissolved in water (5 mL) and extracted with ethyl acetate (3 x 5 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 5-bromo-2-chloro-4-methoxypyrimidine (432 mg, 88% yield) as a white solid.LCMS-ESI (m/z): C5H4BrClN2O Calculated value: 223.4; Measured value: 224.2 [M + H]+, tR = 7.66 min (Method 2) The following is a summary of the results.

References

[1] Patent: WO2011/76419, 2011, A1. Location in patent: Page/Page column 119
[2] Patent: EP2338888, 2011, A1. Location in patent: Paragraph 0173; 0174
[3] Tetrahedron Letters, 2006, vol. 47, # 26, p. 4415 - 4418
[4] Patent: CN106588884, 2017, A. Location in patent: Paragraph 0299; 0303; 0304; 0305
[5] Patent: WO2013/90454, 2013, A2. Location in patent: Paragraph 00386

5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE Preparation Products And Raw materials

Raw materials

5-Bromo-2,4-dichloropyrimidine Sodium Methanol

Preparation Products

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5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE Suppliers

China 78 India 2 Switzerland 1 United Kingdom 3 United States 14 Global 98

J & K SCIENTIFIC LTD.

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View Lastest Price from 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE manufacturers

Dideu Industries Group Limited

Product: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 57054-92-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Career Henan Chemical Co

Product: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 57054-92-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-17

57054-92-9, 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINERelated Search:

5-Bromo-2-chlorobenzonitrile 5-Bromo-2-chloro-4-methylpyrimidine 5-BROMO-2-CHLORO-3-IODO-PYRIDINE 5-BROMO-2-CHLORO-1H-BENZIMIDAZOLE 5-Bromo-2-chloro-4,6-dimethylpyrimidine 5-BROMO-2-CHLORO-4-FLUORO-PHENOL 2-CHLORO-4-METHOXYPYRIMIDINE 5-BROMO-4-TERT-BUTOXY-2-CHLOROPYRIMIDINE 5-Bromo-2-chloropyrimidine 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 4-BENZYLOXY-5-BROMO-2-CHLOROPYRIMIDINE

5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE

5-BroMo-2-chloro-4-Methox...

Pyrimidine, 5-bromo-2-chloro-4-methoxy-

2-chloro-5-broMo-4-MethoxypyriMidine

5-Bromo-2-chloro-4-methoxy-1,3-diazine, 5-Bromo-2-chloropyrimidin-4-yl methyl ether

5-Bromo-2-chloro-4-methoxypyrimidine, >=98%

5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH

57054-92-9

Building Blocks

Pyrimidine

Heterocycle-Pyrimidine series