5-Bromo-2-chloro-4-methylpyrimidine
- Product Name
- 5-Bromo-2-chloro-4-methylpyrimidine
- CAS No.
- 633328-95-7
- Chemical Name
- 5-Bromo-2-chloro-4-methylpyrimidine
- Synonyms
- 5-Bromo-2-chloro-4-methylpyrimidine;2-Chloro-5-bromo-4-methylpyrimidine;Pyrimidine, 5-bromo-2-chloro-4-methyl-
- CBNumber
- CB82489690
- Molecular Formula
- C5H4BrClN2
- Formula Weight
- 207.46
- MOL File
- 633328-95-7.mol
5-Bromo-2-chloro-4-methylpyrimidine Property
- Boiling point:
- 281.5±20.0 °C(Predicted)
- Density
- 1.724±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.35±0.29(Predicted)
- Appearance
- Off-white to brown Solid
- InChI
- InChI=1S/C5H4BrClN2/c1-3-4(6)2-8-5(7)9-3/h2H,1H3
- InChIKey
- IIALSLVGUGOODS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Br)C(C)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B690723
- Product name
- 5-Bromo-2-chloro-4-methylpyrimidine
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 3H32-D-99
- Product name
- 5-Bromo-2-chloro-4-methylpyrimidine
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FB44315
- Product name
- 5-Bromo-2-chloro-4-methylpyrimidine
- Packaging
- 2g
- Price
- $116
- Updated
- 2021/12/16
- Product number
- 073821
- Product name
- 5-Bromo-2-chloro-4-methylpyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- W7533
- Product name
- 5-Bromo-2-chloro-4-methylpyrimidine
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
5-Bromo-2-chloro-4-methylpyrimidine Chemical Properties,Usage,Production
Synthesis
36082-50-5
75-16-1
633328-95-7
General procedure for the synthesis of 5-bromo-2-chloro-4-methylpyrimidine from 5-bromo-2,4-dichloropyrimidine and methylmagnesium bromide: A mixture of 5-bromo-2,4-dichloropyrimidine (0.4 g) and iron(III) acetylacetonate (0.062 g) in tetrahydrofuran (10 mL) was cooled to 0 °C. Methylmagnesium bromide (3M solution in diethyl ether, 0.76 mL) was added dropwise and the mixture was stirred at 0°C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated ammonium chloride solution, followed by extraction of the mixture with ethyl acetate (2 x 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using gradient elution with ethyl acetate and n-heptane to afford the target compound 5-bromo-2-chloro-4-methylpyrimidine (0.220 g, 60% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ 8.52 (s,1H), 2.57 (s,3H).
References
[1] Patent: WO2018/108671, 2018, A1. Location in patent: Page/Page column 169; 170
5-Bromo-2-chloro-4-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-chloro-4-methylpyrimidine manufacturers
- Product
- 5-Bromo-2-chloro-4-methylpyrimidine 633328-95-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- 5-Bromo-2-chloro-4-methylpyrimidine 633328-95-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02