ChemicalBook > CAS DataBase List > 5-Bromo-2-chloro-4-methylpyrimidine

5-Bromo-2-chloro-4-methylpyrimidine

Product Name: 5-Bromo-2-chloro-4-methylpyrimidine
CAS No.: 633328-95-7
Chemical Name: 5-Bromo-2-chloro-4-methylpyrimidine
Synonyms: 5-Bromo-2-chloro-4-methylpyrimidine;2-Chloro-5-bromo-4-methylpyrimidine;Pyrimidine, 5-bromo-2-chloro-4-methyl-
CBNumber: CB82489690
Molecular Formula: C5H4BrClN2
Formula Weight: 207.46
MOL File: 633328-95-7.mol

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5-Bromo-2-chloro-4-methylpyrimidine Property

Boiling point:: 281.5±20.0 °C(Predicted)
Density: 1.724±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.35±0.29(Predicted)
Appearance: Off-white to brown Solid
InChI: InChI=1S/C5H4BrClN2/c1-3-4(6)2-8-5(7)9-3/h2H,1H3
InChIKey: IIALSLVGUGOODS-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Br)C(C)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B690723
Product name: 5-Bromo-2-chloro-4-methylpyrimidine
Packaging: 500mg
Price: $85
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-99
Product name: 5-Bromo-2-chloro-4-methylpyrimidine
Packaging: 50mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB44315
Product name: 5-Bromo-2-chloro-4-methylpyrimidine
Packaging: 2g
Price: $116
Updated: 2021/12/16

Matrix Scientific

Product number: 073821
Product name: 5-Bromo-2-chloro-4-methylpyrimidine
Purity: 95+%
Packaging: 250mg
Price: $139
Updated: 2021/12/16

AK Scientific

Product number: W7533
Product name: 5-Bromo-2-chloro-4-methylpyrimidine
Packaging: 5g
Price: $180
Updated: 2021/12/16

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5-Bromo-2-chloro-4-methylpyrimidine Chemical Properties,Usage,Production

Synthesis

36082-50-5

75-16-1

633328-95-7

General procedure for the synthesis of 5-bromo-2-chloro-4-methylpyrimidine from 5-bromo-2,4-dichloropyrimidine and methylmagnesium bromide: A mixture of 5-bromo-2,4-dichloropyrimidine (0.4 g) and iron(III) acetylacetonate (0.062 g) in tetrahydrofuran (10 mL) was cooled to 0 °C. Methylmagnesium bromide (3M solution in diethyl ether, 0.76 mL) was added dropwise and the mixture was stirred at 0°C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated ammonium chloride solution, followed by extraction of the mixture with ethyl acetate (2 x 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using gradient elution with ethyl acetate and n-heptane to afford the target compound 5-bromo-2-chloro-4-methylpyrimidine (0.220 g, 60% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ 8.52 (s,1H), 2.57 (s,3H).

References

[1] Patent: WO2018/108671, 2018, A1. Location in patent: Page/Page column 169; 170

5-Bromo-2-chloro-4-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Bromo-2-chloro-4-methylpyrimidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Bromo-2-chloro-4-methylpyrimidine 633328-95-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: 5-Bromo-2-chloro-4-methylpyrimidine 633328-95-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

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