4-Amino-5-bromo-2-chloropyrimidine

Uses

Product Name: 4-Amino-5-bromo-2-chloropyrimidine
CAS No.: 205672-25-9
Chemical Name: 4-Amino-5-bromo-2-chloropyrimidine
Synonyms: 5-Bromo-2-chloropyrimidin-4-amine;CAS:205672-25-9;5-BroMo-2-chloro-4-pyriMidinaMine;4-Amino-5-bromo-2-chloropyrimidin;4-AMINO-5-BROMO-2-CHLOROPYRIMIDINE;4-Pyrimidinamine, 5-bromo-2-chloro-;5-BroMo-2-chloro-pyriMidin-4-ylaMine;4-AMINO-5-BROMO-2-CHLOROPYRIMIDINE, 95+%;5-Bromo-2-chloropyrimidin-4-amine, 4-Amino-5-bromo-2-chloro-1,3-diazine
CBNumber: CB2242952
Molecular Formula: C4H3BrClN3
Formula Weight: 208.44
MOL File: 205672-25-9.mol

More

Less

4-Amino-5-bromo-2-chloropyrimidine Property

Melting point:: 187-188 °C(Solv: acetonitrile (75-05-8))
Boiling point:: 369.8±22.0 °C(Predicted)
Density: 1.960±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.68±0.10(Predicted)
form: Liquid
color: Clear brown to purple
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C4H3BrClN3/c5-2-1-8-4(6)9-3(2)7/h1H,(H2,7,8,9)
InChIKey: QOWALNIZDHZTSM-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Br)C(N)=N1

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-37/38-41-36/37/38
Safety Statements: 26-39-36/37/39
RIDADR: UN2811
HS Code: 29335990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A602048
Product name: 4-Amino-5-bromo-2-chloropyrimidine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA139934
Product name: 4-Amino-5-bromo-2-chloropyrimidine
Packaging: 10g
Price: $125
Updated: 2021/12/16

Oakwood

Product number: 016248
Product name: 4-Amino-5-bromo-2-chloropyrimidine
Purity: 99%
Packaging: 5g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA139934
Product name: 4-Amino-5-bromo-2-chloropyrimidine
Packaging: 5G
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 071945
Product name: 4-Amino-5-bromo-2-chloropyrimidine
Purity: 95+%
Packaging: 5g
Price: $77
Updated: 2021/12/16

More

Less

4-Amino-5-bromo-2-chloropyrimidine Chemical Properties,Usage,Production

Uses

4-Amino-5-bromo-2-chloropyrimidine is a useful research chemical, an intermediate in the synthesis of pyrimidine Schiff bases with antibacterial, antioxidant, anti-inflammatory and antifungal properties.

Uses

4-Amino-5-bromo-2-chloropyrimidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Synthesis

36082-50-5

205672-25-9

1. Dissolve 5-bromo-2,4-dichloropyrimidine in a solvent mixture of N-hydroxysuccinimide (NHS)/methanol (MEOH) and stir the reaction at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting solid was washed with deionized water (H2O) and dried in vacuum to obtain a white solid 5-bromo-2-chloropyrimidin-4-amine in quantitative yield. 2. The above white solid was dissolved in a mixed solvent of dimethyl sulfoxide (DMSO)/water (H2O). To the solution was added 1,4-diazabicyclo[2.2.2]octane (DABCO) and sodium cyanide (NaCN), and the reaction mixture was heated to 60 °C for the reaction. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (AcOEt). The organic phases were combined and dried with anhydrous sodium sulfate (Na2SO4). Purification by silica gel column chromatography with ethyl acetate-hexane as eluent afforded 4-amino-5-bromopyrimidine-2-carbonitrile as a white solid. 3. The above product was dissolved in N,N-dimethylformamide (DMF) under the protection of nitrogen (N2) and 1-chloro-4-prop-2-ynylbenzene, (PPh3)2PdCl2 and cuprous iodide (CuI) were added. The reaction mixture was stirred at 80°C for the reaction. After completion of the reaction, the reaction was quenched by addition of saturated aqueous ammonium chloride (NH4Cl) and stirring was continued for 1 hour. The mixture was extracted twice with ethyl acetate (AcOEt). The organic phases were combined, washed with aqueous sodium bicarbonate (NaHCO3) and dried over anhydrous sodium sulfate (Na2SO4). The target product 4-amino-5-bromo-2-chloropyrimidine was purified by silica gel fast column chromatography using ethyl acetate-hexane as eluent.

References

[1] Patent: WO2004/69256, 2004, A1. Location in patent: Page/Page column 35
[2] Patent: WO2011/112766, 2011, A2. Location in patent: Page/Page column 125; 126
[3] Patent: WO2015/155042, 2015, A1. Location in patent: Page/Page column 24
[4] Patent: WO2016/166255, 2016, A1. Location in patent: Page/Page column 29
[5] Tetrahedron Letters, 2001, vol. 42, # 6, p. 999 - 1001

4-Amino-5-bromo-2-chloropyrimidine Preparation Products And Raw materials

Raw materials

5-Bromo-2,4-dichloropyrimidine Tetrahydrofuran Ammonia

Preparation Products

More

Less

4-Amino-5-bromo-2-chloropyrimidine Suppliers

Canada 1 China 173 France 1 Germany 4 India 7 Japan 1 United Kingdom 12 United States 34 Global 233

Shanghai Xinlitai Pharmaceutical Co. , Ltd.

Tel: 18616665298
Email: wenjie.li@bocimed.com
Country: China
ProdList: 234
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

More

Less

View Lastest Price from 4-Amino-5-bromo-2-chloropyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Amino-5-bromo-2-chloropyrimidine 205672-25-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-07

Shaanxi Dideu Medichem Co. Ltd

Product: 5-bromo-2-chloropyrimidin-4-amine 205672-25-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Career Henan Chemical Co

Product: 4-Amino-5-bromo-2-chloropyrimidine 205672-25-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 726
Release date: 2019-09-01

205672-25-9, 4-Amino-5-bromo-2-chloropyrimidineRelated Search:

2-Chloropyrimidine Dibenzylamine 3-Aminophenol Glycine 5-Bromo-2-chloropyrimidine 6-Aminocaproic acid Chlorobromoisocyanurate BCDMH 4-Aminopyrimidine Triethanolamine Triallylamine Bis(2-ethylhexyl)amine ALTRENOGEST Tris(hydroxymethyl)aminomethane Bromine 5-bromo-2-chloro-4-morpholinopyrimidine 5-Bromo-2-chloro-4-(dimethylamino)pyrimidine 4-AMINO-5-BROMO-6-CHLOROPYRIMIDINE

4-AMINO-5-BROMO-2-CHLOROPYRIMIDINE

5-BroMo-2-chloro-pyriMidin-4-ylaMine

4-AMINO-5-BROMO-2-CHLOROPYRIMIDINE, 95+%

5-Bromo-2-chloropyrimidin-4-amine

5-Bromo-2-chloropyrimidin-4-amine, 4-Amino-5-bromo-2-chloro-1,3-diazine

5-BroMo-2-chloro-4-pyriMidinaMine

4-Pyrimidinamine, 5-bromo-2-chloro-

4-Amino-5-bromo-2-chloropyrimidin

CAS:205672-25-9

205672-25-9

C4H3BrClN3

Heterocycle-Pyrimidine series