5-Bromo-2,2-difluorobenzodioxole

Product Name: 5-Bromo-2,2-difluorobenzodioxole
CAS No.: 33070-32-5
Chemical Name: 5-Bromo-2,2-difluorobenzodioxole
Synonyms: 5-bromo-2,2-difluorobenzo[d][1,3]dioxole;3,4-[(Difluo;5-Bromo-2,2-difL;5-BroMo-2,2-difluoro-benz...;5-BROMO-2,2-DIFLUOROBENZODIOXOLE;5-BROMO-2,2-DIFLUORO-1,3-BENZODIOXOLE;5-BROMO-2,2-DIFLUORO-BENZO[1,3]DIOXOLE;1,3-Benzodioxole, 5-bromo-2,2-difluoro-;5-Bromo-2,2-difluoro-1,3-benzodioxole98%;5-broMo-2,2-difluoro-2H-1,3-benzodioxole
CBNumber: CB5761366
Molecular Formula: C7H3BrF2O2
Formula Weight: 237
MOL File: 33070-32-5.mol

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5-Bromo-2,2-difluorobenzodioxole Property

Boiling point:: 78-79°C 20mm
Density: 1,74 g/cm³
refractive index: 1.4967
Flash point:: >75°C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Miscible with hexane.
form: clear liquid
color: Colorless to Almost colorless
BRN: 1425209
InChI: InChI=1S/C7H3BrF2O2/c8-4-1-2-5-6(3-4)12-7(9,10)11-5/h1-3H
InChIKey: SZRHWHHXVXSGMT-UHFFFAOYSA-N
SMILES: O1C2=CC=C(Br)C=C2OC1(F)F
CAS DataBase Reference: 33070-32-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36-41
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3781
Product name: 5-Bromo-2,2-difluoro-1,3-benzodioxole
Purity: >97.0%(GC)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: B3781
Product name: 5-Bromo-2,2-difluoro-1,3-benzodioxole
Purity: >97.0%(GC)
Packaging: 25g
Price: $205
Updated: 2025/07/31

TRC

Product number: B689683
Product name: 5-Bromo-2,2-difluorobenzo[d][1,3]dioxole
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB149846
Product name: 5-Bromo-2,2-difluoro-1,3-benzodioxole
Packaging: 10g
Price: $76
Updated: 2021/12/16

Matrix Scientific

Product number: 057696
Product name: 5-Bromo-2,2-difluoro-1,3-benzodioxole
Purity: 95%
Packaging: 25g
Price: $91
Updated: 2021/12/16

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5-Bromo-2,2-difluorobenzodioxole Chemical Properties,Usage,Production

Uses

5-Bromo-2,2-difluoro-1,3- benzodioxole is used as a precursor in organic synthesis. It is used to prepare 5-bromo-2,2-difluoro-1,3-benzodioxole-4-carboxylic acid. It serves as an intermediate in active pharmaceutical ingredients, agrochemicals and in dyestuff field.

Synthesis

1583-59-1

33070-32-5

General procedure for the synthesis of 2,2-difluoro-5-bromo-1,3-benzodioxole from 2,2-difluoro-1,3-benzodioxole: In a 1000 mL round-bottomed flask fitted with a mechanical stirrer, a reflux condenser, and a pressure-equilibrium charging funnel, 2,2-difluoro-1,3-benzodioxole (200 g, 1.27 mol) and water (456 g, 25.3 mol). Bromine (284 g, 1.77 mol) was added dropwise at 25 °C for 1 hour. The temperature of the reaction mixture was increased from 25 °C to 85 °C during the dropwise addition. The reaction mixture was kept at 85 °C for 8 h. The reaction process was monitored by liquid chromatography. After completion of the reaction, the reaction mixture was cooled to 25°C. The organic and aqueous layers were separated, and the organic layer was washed sequentially with sodium bisulfite solution and sodium bicarbonate solution to obtain the crude product of 2,2-difluoro-5-bromo-1,3-benzodioxole. The crude product was purified by vacuum distillation. Yield: 80%; purity: 99.8% (determined by liquid chromatography).

References

[1] Patent: WO2017/46816, 2017, A2. Location in patent: Page/Page column 9-10
[2] Patent: EP1595877, 2005, A1. Location in patent: Page/Page column 4
[3] European Journal of Organic Chemistry, 2004, # 1, p. 64 - 68
[4] Patent: WO2016/38627, 2016, A1. Location in patent: Page/Page column 4

5-Bromo-2,2-difluorobenzodioxole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2,2-difluorobenzodioxole Suppliers

Americas 1 Belgium 1 China 158 Europe 1 Germany 4 India 6 Italy 1 Japan 2 United Kingdom 11 United States 29 Global 214

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View Lastest Price from 5-Bromo-2,2-difluorobenzodioxole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromo-2,2-difluorobenzodioxole 33070-32-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-24

RongNa Biotechnology Co.,Ltd

Product: 5-Bromo-2,2-difluorobenzodioxole 33070-32-5
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-05-04

Career Henan Chemical Co

Product: 5-Bromo-2,2-difluorobenzodioxole 33070-32-5
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%-99%
Supply Ability: 1kg-100kg
Release date: 2020-01-07

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33070-32-5

ARYL HALIDE

Heterocycles series