1,3-Benzodioxole

Product Name: 1,3-Benzodioxole
CAS No.: 274-09-9
Chemical Name: 1,3-Benzodioxole
Synonyms: Benzo[d][1,3]dioxole;Benzodioxole;1,2-METHYLENEDIOXYBENZENE;1,2-Methylenedioxybenzene (MDB);1,3-DIOXAINDANE;1,3-BENZODIOXOL;BENZO[1,3]DIOXOLE;1,2-METHYLENDIOXYBENZENE;3,4-METHYLENEDIOXYBENZENE;MDB
CBNumber: CB4180652
Molecular Formula: C7H6O2
Formula Weight: 122.12
MOL File: 274-09-9.mol

More

Less

1,3-Benzodioxole Property

Melting point:: -18 °C
Boiling point:: 172-173 °C(lit.)
Density: 1.064 g/mL at 25 °C(lit.)
vapor pressure: 12 mm Hg ( 25 °C)
refractive index: n20/D 1.539(lit.)
Flash point:: 131 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: 2g/l
form: Powder
color: Yellow to orange to brown
Water Solubility: 0.2 g/100 mL (25 ºC)
BRN: 115506
InChIKey: FTNJQNQLEGKTGD-UHFFFAOYSA-N
LogP: 2.08
CAS DataBase Reference: 274-09-9(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Benzodioxole(274-09-9)
EPA Substance Registry System: 1,3-Benzodioxole (274-09-9)

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/22-22-10-36/37/38-20/21/22-10/22
Safety Statements: 23-24/25-36/37/39-26-16-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: DA5600000
Hazard Note: Irritant
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29329970

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 159166
Product name: 1,3-Benzodioxole
Purity: 99%
Packaging: 50g
Price: $63.9
Updated: 2024/03/01

TCI Chemical

Product number: M0658
Product name: 1,2-Methylenedioxybenzene
Purity: >99.0%(GC)
Packaging: 25mL
Price: $25
Updated: 2024/03/01

TCI Chemical

Product number: M0658
Product name: 1,2-Methylenedioxybenzene
Purity: >99.0%(GC)
Packaging: 100mL
Price: $64
Updated: 2024/03/01

Alfa Aesar

Product number: A14192
Product name: 1,3-Benzodioxole, 99%
Packaging: 50g
Price: $36.65
Updated: 2024/03/01

Alfa Aesar

Product number: A14192
Product name: 1,3-Benzodioxole, 99%
Packaging: 250g
Price: $163.65
Updated: 2024/03/01

More

Less

1,3-Benzodioxole Chemical Properties,Usage,Production

Description

1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.

Chemical Properties

clear colourless to light yellow liquid. Insoluble in acids.

Uses

1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.

Definition

ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.

Production Methods

1,3-Benzodioxole is a colorless liquid. This compound is prepared by the reaction of catechol and dihalomethanes, for example, by use of concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.

Application

1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.

General Description

Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.

1,3-Benzodioxole Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Ethanol Acetone Calcium chloride Paraformaldehyde Diethyl ether Catechol Dimethyl sulfoxide Sodium hydroxide

Preparation Products

Piperonyl chloride 3,4-METHYLENEDIOXYPHENYL ISOTHIOCYANATE 3,4-(Methylenedioxy)phenylacetonitrile 1,2-(Methylenedioxy)-4-nitrobenzene Piperonyl aldehyde 4-NITROCATECHOL PIPERONYL FORMALDEHYDE Ethyl vanillin

More

Less

1,3-Benzodioxole Suppliers

Americas 1 Belgium 2 China 356 Europe 3 France 2 Germany 12 India 33 Italy 3 Japan 10 Slovakia 1 South Korea 2 Spain 1 Sweden 1 Switzerland 2 Thailand 1 United Kingdom 21 United States 61 USA 1 Global 513

Hangzhou Lenny Technology Co. , Ltd.

Tel: 571-88086013
Fax: 0571- 88088387
Email: sunnie@rdpharm.com
Country: China
ProdList: 88
Advantage: 60

Shanghai Xianggeng Technology Development Co. Ltd.

Tel: 021-021-56152668 18116302010
Fax: 18116300787
Email: sharing@sharingtechcn.com
Country: China
ProdList: 502
Advantage: 58

Shanghai Leju Biotechnology Co., Ltd.

Tel: 021-56328558 13671549194
Fax: 021-56328558
Email: sales2@reliablebiochem.com
Country: China
ProdList: 299
Advantage: 58

nanjing huayan chemical corp.

Tel: 25-86661363 18951712139
Email: ruishi@hychemm.com
Country: China
ProdList: 52
Advantage: 58

Jinan Shengqi Pharmaceutical Co., Ltd

Tel: 0531-88892685 18660160628
Email: 2153390475@qq.com
Country: China
ProdList: 131
Advantage: 58

Nanjing Yihua Biotechnology Co., Ltd

Tel: 15850730945; 15850730945
Email: 1334103687@qq.com
Country: China
ProdList: 286
Advantage: 58

Nanjing Dilu Pharmaceutical Co., Ltd

Tel: 18014482516; 18014482516
Email: 977144864@qq.com
Country: China
ProdList: 376
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3576
Advantage: 66

More

Less

View Lastest Price from 1,3-Benzodioxole manufacturers

Nanjing Deda New Material Technology Ltd.

Product: 1,3-Benzodioxole 274-09-9
Price: US $10.00-30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100ton/ month
Release date: 2024-03-29

airuikechemical co., ltd.

Product: 1,3-Benzodioxole 274-09-9
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-07

Henan Fengda Chemical Co., Ltd

Product: 1,3-Benzodioxole 274-09-9
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

274-09-9, 1,3-BenzodioxoleRelated Search:

Allylbenzene o-Anisaldehyde m-Anisyl alcohol 4-Methoxybenzoic acid Benzene Phthalic acid Isophthalic acid 3-Methoxybenzaldehyde Potassium hydrogen phthalate Selenium dioxide 4-Methoxybenzyl cyanide Benzophenone Black Pepper Oil Bis(2-ethylhexyl) phthalate m-Phenylenediamine p-Phenylenediamine Oxybenzone Anisole

1,2-Methylenedioxybenzene (MDB)

1,2- Methylenetwophenoxy

Anti-ABR (C-terminal) antibody produced in rabbit

FLJ45954

1,2-Methylenedioxybenzene 1,3-Benzodioxole

1,2-methylenedioxy-benzen

1,3-Dioxaindan

1,3-Dioxindan

2h-1,3-benzodioxole

Benzene, 1,2-(methylenedioxy)-

Benzene, 1,2-[methylenebis(oxy)]-

Benzodioxole

o-(methylenedioxy)benzene

o-Methylenedioxybenzene

Paroxetine Impurity 14

Pepper ring

1.2-Methylene Benzene

1,2-(Methylenedioxy)benzene 1,3-Dioxainda

1,2-(Methylenedioxy)benzene 1,3-Dioxaindane

(trans)-4-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-methylpiperidin-3-yl) methanol

Pepper rings

1,2-метелендиоксибензол, 1,2-(Methylenedioxy)benzene, 1,3-Benzodioxole Производитель: Alfa Aesar - Великобритания

1,2-метелендиоксибензол, 1,2-(Methylenedioxy)benzene, 1,3-Benzodioxole

Perfume intermediate

METHYLENEDIOXY BENZENE

MDB

BENZO[1,3]DIOXOLE

3,4-METHYLENEDIOXYBENZENE

1,3-DIOXAINDANE

1,3-BENZODIOXALE

1,3-BENZODIOXOL

1,3-BENZODIOXOLANE

1,3-BENZODIOXOLE

1,2-METHYLENDIOXYBENZENE

1,2-METHYLENE DIOXO BENZENE

1,2-METHYLENEDIOXYBENZENE

1,3-Benzodioxole99+%

1,2-Methylendioxybenzene 98%

Formaldehyde o-phenylene acetal

2-methylenedioxy-benzen

1,2-Methylen dioxidbenzene

1,3-Benzodioxole, 99% 50GR

1,2-METHYLENEDIOXYBENZENE FOR SYNTHESIS

Benzene, 1,2-(Methylenedioxy)- (6CI,8CI)

NSC 30095

Benzo[d][1,3]dioxole

Methyline Dioxybenzene

1,2-Methylenedioxybenzene&gt

1.3-BENZODIOXOLE 274-09-9

1,3-Benzodioxole ISO 9001：2015 REACH

((3SR,4RS)-4-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-methylpiperidin-3-yl)methanol

1,3-Benzodioxole CAS:274-09-9

Benzodioxole/1,3-Benzodioxole

274-09-9

274-9-9

274-04-9

C7H4O2

Building Blocks