ChemicalBook > CAS DataBase List > 1,3-Benzodioxole

1,3-Benzodioxole

Product Name: 1,3-Benzodioxole
CAS No.: 274-09-9
Chemical Name: 1,3-Benzodioxole
Synonyms: Benzo[d][1,3]dioxole;Benzodioxole;1,2-METHYLENEDIOXYBENZENE;1,2-Methylenedioxybenzene (MDB);1,3-DIOXAINDANE;1,3-BENZODIOXOL;BENZO[1,3]DIOXOLE;1,2-METHYLENDIOXYBENZENE;3,4-METHYLENEDIOXYBENZENE;MDB
CBNumber: CB4180652
Molecular Formula: C7H6O2
Formula Weight: 122.12
MOL File: 274-09-9.mol

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1,3-Benzodioxole Property

Melting point:: -18 °C
Boiling point:: 172-173 °C(lit.)
Density: 1.064 g/mL at 25 °C(lit.)
vapor pressure: 12 mm Hg ( 25 °C)
refractive index: n20/D 1.539(lit.)
Flash point:: 131 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: 2g/l
form: Powder
color: Yellow to orange to brown
Water Solubility: 0.2 g/100 mL (25 ºC)
BRN: 115506
InChIKey: FTNJQNQLEGKTGD-UHFFFAOYSA-N
LogP: 2.08
CAS DataBase Reference: 274-09-9(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Benzodioxole(274-09-9)
EPA Substance Registry System: 1,3-Benzodioxole (274-09-9)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/22-22-10-36/37/38-20/21/22-10/22
Safety Statements: 23-24/25-36/37/39-26-16-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: DA5600000
Hazard Note: Irritant
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29329970

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 159166
Product name: 1,3-Benzodioxole
Purity: 99%
Packaging: 50g
Price: $65.9
Updated: 2025/07/31

TCI Chemical

Product number: M0658
Product name: 1,2-Methylenedioxybenzene
Purity: >99.0%(GC)
Packaging: 25mL
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: M0658
Product name: 1,2-Methylenedioxybenzene
Purity: >99.0%(GC)
Packaging: 100mL
Price: $64
Updated: 2025/07/31

TCI Chemical

Product number: M0658
Product name: 1,2-Methylenedioxybenzene
Purity: >99.0%(GC)
Packaging: 500mL
Price: $198
Updated: 2025/07/31

Usbiological

Product number: 410941
Product name: 1,3-Benzodioxole
Packaging: 5g
Price: $305
Updated: 2021/12/16

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1,3-Benzodioxole Chemical Properties,Usage,Production

Description

1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.

Chemical Properties

clear colourless to light yellow liquid. Insoluble in acids.

Uses

1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.

Definition

ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.

Production Methods

1,3-Benzodioxole is synthesized through the reaction of catechol with dihalomethanes, typically employing a concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.

Application

1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.

General Description

Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.

1,3-Benzodioxole Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Ethanol Acetone Calcium chloride Paraformaldehyde Diethyl ether Catechol Dimethyl sulfoxide Sodium hydroxide

Preparation Products

Piperonyl chloride 3,4-METHYLENEDIOXYPHENYL ISOTHIOCYANATE 3,4-(Methylenedioxy)phenylacetonitrile 1,2-(Methylenedioxy)-4-nitrobenzene Piperonyl aldehyde 4-NITROCATECHOL PIPERONYL FORMALDEHYDE Ethyl vanillin

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View Lastest Price from 1,3-Benzodioxole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,3-Benzodioxole 274-09-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,3-Benzodioxole 274-09-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Henan Aochuang Chemical Co.,Ltd.

Product: 1,3-Benzodioxole 274-09-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-14

274-09-9, 1,3-BenzodioxoleRelated Search:

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Pepper rings

1,2-метелендиоксибензол, 1,2-(Methylenedioxy)benzene, 1,3-Benzodioxole Производитель: Alfa Aesar - Великобритания

1,2-метелендиоксибензол, 1,2-(Methylenedioxy)benzene, 1,3-Benzodioxole

Perfume intermediate

METHYLENEDIOXY BENZENE

MDB

BENZO[1,3]DIOXOLE

3,4-METHYLENEDIOXYBENZENE

1,3-DIOXAINDANE

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Formaldehyde o-phenylene acetal

2-methylenedioxy-benzen

1,2-Methylen dioxidbenzene

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1,2-METHYLENEDIOXYBENZENE FOR SYNTHESIS

Benzene, 1,2-(Methylenedioxy)- (6CI,8CI)

NSC 30095

Benzo[d][1,3]dioxole

Methyline Dioxybenzene

1,2-Methylenedioxybenzene&gt

1.3-BENZODIOXOLE 274-09-9

1,3-Benzodioxole ISO 9001：2015 REACH

((3SR,4RS)-4-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-methylpiperidin-3-yl)methanol

1,3-Benzodioxole CAS:274-09-9

Benzodioxole/1,3-Benzodioxole

1,2-METHYLENEDIOXYBENZENE 99.0%

274-09-9

274-9-9

274-04-9

C7H4O2