ChemicalBook > CAS DataBase List > 5-Bromo-2,2-difluorobenzodioxole

5-Bromo-2,2-difluorobenzodioxole

Product Name
5-Bromo-2,2-difluorobenzodioxole
CAS No.
33070-32-5
Chemical Name
5-Bromo-2,2-difluorobenzodioxole
Synonyms
5-bromo-2,2-difluorobenzo[d][1,3]dioxole;3,4-[(Difluo;5-Bromo-2,2-difL;5-BroMo-2,2-difluoro-benz...;5-BROMO-2,2-DIFLUOROBENZODIOXOLE;5-BROMO-2,2-DIFLUORO-1,3-BENZODIOXOLE;5-BROMO-2,2-DIFLUORO-BENZO[1,3]DIOXOLE;1,3-Benzodioxole, 5-bromo-2,2-difluoro-;5-Bromo-2,2-difluoro-1,3-benzodioxole98%;5-broMo-2,2-difluoro-2H-1,3-benzodioxole
CBNumber
CB5761366
Molecular Formula
C7H3BrF2O2
Formula Weight
237
MOL File
33070-32-5.mol
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5-Bromo-2,2-difluorobenzodioxole Property

Boiling point:
78-79°C 20mm
Density 
1,74 g/cm3
refractive index 
1.4967
Flash point:
>75°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Miscible with hexane.
form 
clear liquid
color 
Colorless to Almost colorless
BRN 
1425209
InChI
InChI=1S/C7H3BrF2O2/c8-4-1-2-5-6(3-4)12-7(9,10)11-5/h1-3H
InChIKey
SZRHWHHXVXSGMT-UHFFFAOYSA-N
SMILES
O1C2=CC=C(Br)C=C2OC1(F)F
CAS DataBase Reference
33070-32-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-41
Safety Statements 
26-36
HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3781
Product name
5-Bromo-2,2-difluoro-1,3-benzodioxole
Purity
>97.0%(GC)
Packaging
5g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
B3781
Product name
5-Bromo-2,2-difluoro-1,3-benzodioxole
Purity
>97.0%(GC)
Packaging
25g
Price
$205
Updated
2025/07/31
TRC
Product number
B689683
Product name
5-Bromo-2,2-difluorobenzo[d][1,3]dioxole
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
057696
Product name
5-Bromo-2,2-difluoro-1,3-benzodioxole
Purity
95%
Packaging
1g
Price
$10
Updated
2021/12/16
AK Scientific
Product number
J54269
Product name
5-Bromo-2,2-difluorobenzo[d][1,3]dioxole
Packaging
1g
Price
$13
Updated
2021/12/16
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5-Bromo-2,2-difluorobenzodioxole Chemical Properties,Usage,Production

Uses

5-Bromo-2,2-difluoro-1,3- benzodioxole is used as a precursor in organic synthesis. It is used to prepare 5-bromo-2,2-difluoro-1,3-benzodioxole-4-carboxylic acid. It serves as an intermediate in active pharmaceutical ingredients, agrochemicals and in dyestuff field.

Synthesis

1583-59-1

33070-32-5

General procedure for the synthesis of 2,2-difluoro-5-bromo-1,3-benzodioxole from 2,2-difluoro-1,3-benzodioxole: In a 1000 mL round-bottomed flask fitted with a mechanical stirrer, a reflux condenser, and a pressure-equilibrium charging funnel, 2,2-difluoro-1,3-benzodioxole (200 g, 1.27 mol) and water (456 g, 25.3 mol). Bromine (284 g, 1.77 mol) was added dropwise at 25 °C for 1 hour. The temperature of the reaction mixture was increased from 25 °C to 85 °C during the dropwise addition. The reaction mixture was kept at 85 °C for 8 h. The reaction process was monitored by liquid chromatography. After completion of the reaction, the reaction mixture was cooled to 25°C. The organic and aqueous layers were separated, and the organic layer was washed sequentially with sodium bisulfite solution and sodium bicarbonate solution to obtain the crude product of 2,2-difluoro-5-bromo-1,3-benzodioxole. The crude product was purified by vacuum distillation. Yield: 80%; purity: 99.8% (determined by liquid chromatography).

References

[1] Patent: WO2017/46816, 2017, A2. Location in patent: Page/Page column 9-10
[2] Patent: EP1595877, 2005, A1. Location in patent: Page/Page column 4
[3] European Journal of Organic Chemistry, 2004, # 1, p. 64 - 68
[4] Patent: WO2016/38627, 2016, A1. Location in patent: Page/Page column 4

5-Bromo-2,2-difluorobenzodioxole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Bromo-2,2-difluorobenzodioxole manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Bromo-2,2-difluorobenzodioxole 33070-32-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-24
RongNa Biotechnology Co.,Ltd
Product
5-Bromo-2,2-difluorobenzodioxole 33070-32-5
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
1 ton
Release date
2025-05-04
Career Henan Chemical Co
Product
5-Bromo-2,2-difluorobenzodioxole 33070-32-5
Price
US $5.50/KG
Min. Order
1KG
Purity
98%-99%
Supply Ability
1kg-100kg
Release date
2020-01-07

33070-32-5, 5-Bromo-2,2-difluorobenzodioxoleRelated Search:

Benzene 5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE 5-Bromo-2,4-dichloropyrimidine 5-BROMO-2,4-DIMETHOXYPYRIMIDINE Ethyl bromodifluoroacetate Benzyldodecyldimethylammonium bromide 1,3-Benzodioxole Decabromodiphenyl Ethane Xylene Benzbromarone 2,2-Difluoro-1,3-benzodioxole 3-(DIFLUOROMETHOXY)BROMOBENZENE 4-(DIFLUOROMETHOXY)BROMOBENZENE 4-Bromo-1,2-(methylenedioxy)benzene 2-(DIFLUOROMETHOXY)PHENOL 98 Bromine 5-AMINO-6-BROMO-2,2-DIFLUOROBENZODIOXOLE 5-Bromo-2,2-difluorobenzodioxole

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  • 5-bromo-2,2-difluorobenzo[d][1,3]dioxole
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  • 5-broMo-2,2-difluoro-2H-1,3-benzodioxole
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  • ARYL HALIDE
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