5-Bromo-2,2-difluorobenzodioxole
- Product Name
- 5-Bromo-2,2-difluorobenzodioxole
- CAS No.
- 33070-32-5
- Chemical Name
- 5-Bromo-2,2-difluorobenzodioxole
- Synonyms
- 5-bromo-2,2-difluorobenzo[d][1,3]dioxole;3,4-[(Difluo;5-Bromo-2,2-difL;5-BroMo-2,2-difluoro-benz...;5-BROMO-2,2-DIFLUOROBENZODIOXOLE;5-BROMO-2,2-DIFLUORO-1,3-BENZODIOXOLE;5-BROMO-2,2-DIFLUORO-BENZO[1,3]DIOXOLE;1,3-Benzodioxole, 5-bromo-2,2-difluoro-;5-Bromo-2,2-difluoro-1,3-benzodioxole98%;5-broMo-2,2-difluoro-2H-1,3-benzodioxole
- CBNumber
- CB5761366
- Molecular Formula
- C7H3BrF2O2
- Formula Weight
- 237
- MOL File
- 33070-32-5.mol
5-Bromo-2,2-difluorobenzodioxole Property
- Boiling point:
- 78-79°C 20mm
- Density
- 1,74 g/cm3
- refractive index
- 1.4967
- Flash point:
- >75°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Miscible with hexane.
- form
- clear liquid
- color
- Colorless to Almost colorless
- BRN
- 1425209
- InChI
- InChI=1S/C7H3BrF2O2/c8-4-1-2-5-6(3-4)12-7(9,10)11-5/h1-3H
- InChIKey
- SZRHWHHXVXSGMT-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(Br)C=C2OC1(F)F
- CAS DataBase Reference
- 33070-32-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B3781
- Product name
- 5-Bromo-2,2-difluoro-1,3-benzodioxole
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- B3781
- Product name
- 5-Bromo-2,2-difluoro-1,3-benzodioxole
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $205
- Updated
- 2025/07/31
- Product number
- B689683
- Product name
- 5-Bromo-2,2-difluorobenzo[d][1,3]dioxole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB149846
- Product name
- 5-Bromo-2,2-difluoro-1,3-benzodioxole
- Packaging
- 10g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 057696
- Product name
- 5-Bromo-2,2-difluoro-1,3-benzodioxole
- Purity
- 95%
- Packaging
- 25g
- Price
- $91
- Updated
- 2021/12/16
5-Bromo-2,2-difluorobenzodioxole Chemical Properties,Usage,Production
Uses
5-Bromo-2,2-difluoro-1,3- benzodioxole is used as a precursor in organic synthesis. It is used to prepare 5-bromo-2,2-difluoro-1,3-benzodioxole-4-carboxylic acid. It serves as an intermediate in active pharmaceutical ingredients, agrochemicals and in dyestuff field.
Synthesis
1583-59-1
33070-32-5
General procedure for the synthesis of 2,2-difluoro-5-bromo-1,3-benzodioxole from 2,2-difluoro-1,3-benzodioxole: In a 1000 mL round-bottomed flask fitted with a mechanical stirrer, a reflux condenser, and a pressure-equilibrium charging funnel, 2,2-difluoro-1,3-benzodioxole (200 g, 1.27 mol) and water (456 g, 25.3 mol). Bromine (284 g, 1.77 mol) was added dropwise at 25 °C for 1 hour. The temperature of the reaction mixture was increased from 25 °C to 85 °C during the dropwise addition. The reaction mixture was kept at 85 °C for 8 h. The reaction process was monitored by liquid chromatography. After completion of the reaction, the reaction mixture was cooled to 25°C. The organic and aqueous layers were separated, and the organic layer was washed sequentially with sodium bisulfite solution and sodium bicarbonate solution to obtain the crude product of 2,2-difluoro-5-bromo-1,3-benzodioxole. The crude product was purified by vacuum distillation. Yield: 80%; purity: 99.8% (determined by liquid chromatography).
References
[1] Patent: WO2017/46816, 2017, A2. Location in patent: Page/Page column 9-10
[2] Patent: EP1595877, 2005, A1. Location in patent: Page/Page column 4
[3] European Journal of Organic Chemistry, 2004, # 1, p. 64 - 68
[4] Patent: WO2016/38627, 2016, A1. Location in patent: Page/Page column 4
5-Bromo-2,2-difluorobenzodioxole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2,2-difluorobenzodioxole manufacturers
- Product
- 5-Bromo-2,2-difluorobenzodioxole 33070-32-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- 5-Bromo-2,2-difluorobenzodioxole 33070-32-5
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-05-04
- Product
- 5-Bromo-2,2-difluorobenzodioxole 33070-32-5
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%-99%
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-07