4-Bromo-1,2-(methylenedioxy)benzene
- Product Name
- 4-Bromo-1,2-(methylenedioxy)benzene
- CAS No.
- 2635-13-4
- Chemical Name
- 4-Bromo-1,2-(methylenedioxy)benzene
- Synonyms
- 5-bromobenzo[d][1,3]dioxole;5-BROMO-1,3-BENZODIOXOLE;1,2-METHYLENEDIOXY-4-BROMOBENZENE;1-BROMO-3,4-(METHYLENEDIOXY)BENZENE;enedioxy)benzene;BROMOBENZODIOXOLE;TIMTEC-BB SBB006662;4-Bromo-1,2-(methyL;4-Bromo pepper ring;Paroxetine Impurity 89
- CBNumber
- CB5398696
- Molecular Formula
- C7H5BrO2
- Formula Weight
- 201.02
- MOL File
- 2635-13-4.mol
4-Bromo-1,2-(methylenedioxy)benzene Property
- Boiling point:
- 85-86 °C1 mm Hg(lit.)
- Density
- 1.669 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.583(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, Methanol (Sparingly)
- form
- Liquid
- Specific Gravity
- 1.669
- color
- Clear yellow-orange
- BRN
- 127407
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C7H5BrO2/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3H,4H2
- InChIKey
- FBOYMIDCHINJKC-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(Br)C=C2OC1
- CAS DataBase Reference
- 2635-13-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 288314
- Product name
- 1-Bromo-3,4-(methylenedioxy)benzene
- Purity
- 97%
- Packaging
- 25g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- 288314
- Product name
- 1-Bromo-3,4-(methylenedioxy)benzene
- Purity
- 97%
- Packaging
- 100g
- Price
- $174
- Updated
- 2025/07/31
- Product number
- B1230
- Product name
- 4-Bromo-1,2-methylenedioxybenzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- B1230
- Product name
- 4-Bromo-1,2-methylenedioxybenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- B697153
- Product name
- 4-Bromo-1,2-methylenedioxybenzene
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
4-Bromo-1,2-(methylenedioxy)benzene Chemical Properties,Usage,Production
Chemical Properties
clear yellow-orange liquid
Synthesis Reference(s)
Tetrahedron, 64, p. 4999, 2008 DOI: 10.1016/j.tet.2008.03.085
General Description
The coupling of 1-bromo-3,4-(methylenedioxy)benzene with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.
Synthesis
NBS (1.87 g, 10.50 mmol, 1.05 equiv.), HPLC-grade acetonitrile and benzo[d][1,3]dioxole (10 mmol) were placed into a flask and stirred until completely homogeneous. The solution was pumped through the Corning G1 photoreactor at the desired flow rate. The reaction mixture was collected from the reactor and combined with the two separate streams of toluene and water into a 10-mL Vapourtec static mixer coil; then, the mixture was pumped into a Zaiput liquid-liquid membrane separator, the organic phase was collected and passed twice more through the Zaiput membrane separator. The organic phase was evaporated under reduced pressure, providing the corresponding brominated product 4-Bromo-1,2-(methylenedioxy)benzene.
References
[1] Tetrahedron Letters, 2001, vol. 42, # 39, p. 6941 - 6942
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 39, p. 12869 - 12873
[3] Angew. Chem., 2018, vol. 130, p. 13051 - 13055,5
[4] Organic Letters, 2017, vol. 19, # 16, p. 4243 - 4246
[5] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 440 - 447
4-Bromo-1,2-(methylenedioxy)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-1,2-(methylenedioxy)benzene manufacturers
- Product
- 4-Bromo-1,2-(methylenedioxy)benzene 2635-13-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10
- Product
- 5-Bromo-1,3-benzodioxole 2635-13-4
- Price
- US $200.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000t/month
- Release date
- 2022-11-30
- Product
- 4-Bromo-1,2-(methylenedioxy)benzene 2635-13-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24