3-(Trifluoromethoxy)bromobenzene

Product Name: 3-(Trifluoromethoxy)bromobenzene
CAS No.: 2252-44-0
Chemical Name: 3-(Trifluoromethoxy)bromobenzene
Synonyms: 1-BROMO-3-(TRIFLUOROMETHOXY)BENZENE;1-Bromo-3-(trifL;BUTTPARK 91\57-27;uoromethoxy)benzene;3-(trifluoromrthoxy)bromobenzene;3-(TRIFLUOROMETHOXY)BROMOBENZENE;M-BROMO(TRIFLUOROMETHOXY)BENZENE;3-BROMO(TRIFLUOROMETHOXY)BENZENE;3-(TRILFUOROMETHOXY)BROMOBENZENE;3-Bromo-1-(trifluoromethoxy)benzene
CBNumber: CB9266667
Molecular Formula: C7H4BrF3O
Formula Weight: 241.01
MOL File: 2252-44-0.mol

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3-(Trifluoromethoxy)bromobenzene Property

Boiling point:: 156-158 °C
Density: 1.62 g/mL at 25 °C(lit.)
refractive index: n20/D 1.462(lit.)
Flash point:: 145 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Almost colorless
Specific Gravity: 1.64
BRN: 1945938
InChI: InChI=1S/C7H4BrF3O/c8-5-2-1-3-6(4-5)12-7(9,10)11/h1-4H
InChIKey: WVUDHWBCPSXAFN-UHFFFAOYSA-N
SMILES: C1(Br)=CC=CC(OC(F)(F)F)=C1
CAS DataBase Reference: 2252-44-0(CAS DataBase Reference)
NIST Chemistry Reference: 3-(Trifluoromethoxy)bromobenzene(2252-44-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 343870
Product name: 1-Bromo-3-(trifluoromethoxy)benzene
Purity: 99%
Packaging: 5g
Price: $16.66
Updated: 2025/07/31

TCI Chemical

Product number: B2007
Product name: 1-Bromo-3-(trifluoromethoxy)benzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: B2007
Product name: 1-Bromo-3-(trifluoromethoxy)benzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $60
Updated: 2025/07/31

TRC

Product number: B695173
Product name: 1-Bromo-3-(trifluoromethoxy)benzene
Packaging: 5g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2607-B-53
Product name: 3-(Trifluoromethoxy)bromobenzene
Purity: 99%
Packaging: 100g
Price: $79
Updated: 2021/12/16

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3-(Trifluoromethoxy)bromobenzene Chemical Properties,Usage,Production

Chemical Properties

Clear very faintly yellow liquid

Uses

1-Bromo-3-(trifluoromethoxy)benzene may be used in the preparation of 1,2-dehydro-3-(trifluoromethoxy)benzene. It may be used in the synthesis of new electronically deficient atropisomeric diphosphine ligand (S)-CF₃O-BiPhep [2,2′-bis(diphenylphosphino)-6,6′-ditrifluoromethoxy-1,1′-biphenyl].

General Description

1-Bromo-3-(trifluoromethoxy)benzene undergoes Diels-Alder reaction with lithium diisopropylamide (LDA) in THF and furan, to yield the corresponding 1,4-dihydro-1,4-epoxy-5- or 6-(trifluoromethoxy)naphthalenes.

Synthesis

461-82-5

2252-44-0

The general procedure for the synthesis of 3-trifluoromethoxybromobenzene from p-trifluoromethoxyaniline is described below: Example 5 (comparative experiment) Preparation of 1-bromo-3-trifluoromethoxybenzene using bromine (Br2) in acetic acid medium. This was done as follows: 60 g of acetic acid was added to a 100 mL round bottom flask, followed by the slow addition of 30 g of 4-trifluoromethoxyaniline. After cooling the reaction mixture to 0-5 °C, 27 g of bromine was slowly added dropwise. Upon completion of the reaction, the reaction mixture was analyzed by gas chromatography, which showed 20% unreacted 4-trifluoromethoxyaniline, 37% monobrominated derivatives and more than 41% dibrominated derivatives.

References

[1] Patent: WO2007/107820, 2007, A2. Location in patent: Page/Page column 9
[2] Patent: WO2007/107820, 2007, A2. Location in patent: Page/Page column 9

3-(Trifluoromethoxy)bromobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(Trifluoromethoxy)bromobenzene Suppliers

Americas 1 Belgium 1 China 266 Europe 3 France 1 Germany 3 India 6 Italy 1 Japan 2 Slovakia 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 23 United States 38 Global 351

Nanjing XiLang Chemical Products Co., Ltd.

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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

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View Lastest Price from 3-(Trifluoromethoxy)bromobenzene manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-(Trifluoromethoxy)bromobenzene 2252-44-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Speranza Chemical Co., Ltd.

Product: 1-bromo-3-(trifluoromethoxy)benzene 2252-44-0
Price: US $160.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 300MT/year
Release date: 2019-12-24

Henan Aochuang Chemical Co.,Ltd.

Product: 3-(Trifluoromethoxy)bromobenzene 2252-44-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

2252-44-0, 3-(Trifluoromethoxy)bromobenzeneRelated Search:

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3-(Trifluoromethoxy)bromobenzene ISO 9001：2015 REACH

3-(TRILFUOROMETHOXY)BROMOBENZENE

2252-44-0

C7H4BrF3O

ARYL HALIDE

Building Blocks

Organic Building Blocks

Ethers

Oxygen Compounds

Fluorobenzene

Trifluoroanisole series

Aromatic Ethers

Halides

Phenyls & Phenyl-Het

Miscellaneous

Phenyls & Phenyl-Het

Ethers

Organic Building Blocks

Oxygen Compounds

alkyl bromide