ChemicalBook > CAS DataBase List > 3-(Trifluoromethoxy)bromobenzene

3-(Trifluoromethoxy)bromobenzene

Product Name
3-(Trifluoromethoxy)bromobenzene
CAS No.
2252-44-0
Chemical Name
3-(Trifluoromethoxy)bromobenzene
Synonyms
1-BROMO-3-(TRIFLUOROMETHOXY)BENZENE;1-Bromo-3-(trifL;BUTTPARK 91\57-27;uoromethoxy)benzene;3-(trifluoromrthoxy)bromobenzene;3-(TRIFLUOROMETHOXY)BROMOBENZENE;M-BROMO(TRIFLUOROMETHOXY)BENZENE;3-BROMO(TRIFLUOROMETHOXY)BENZENE;3-(TRILFUOROMETHOXY)BROMOBENZENE;3-Bromo-1-(trifluoromethoxy)benzene
CBNumber
CB9266667
Molecular Formula
C7H4BrF3O
Formula Weight
241.01
MOL File
2252-44-0.mol
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3-(Trifluoromethoxy)bromobenzene Property

Boiling point:
156-158 °C
Density 
1.62 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.462(lit.)
Flash point:
145 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Almost colorless
Specific Gravity
1.64
BRN 
1945938
InChI
InChI=1S/C7H4BrF3O/c8-5-2-1-3-6(4-5)12-7(9,10)11/h1-4H
InChIKey
WVUDHWBCPSXAFN-UHFFFAOYSA-N
SMILES
C1(Br)=CC=CC(OC(F)(F)F)=C1
CAS DataBase Reference
2252-44-0(CAS DataBase Reference)
NIST Chemistry Reference
3-(Trifluoromethoxy)bromobenzene(2252-44-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
343870
Product name
1-Bromo-3-(trifluoromethoxy)benzene
Purity
99%
Packaging
5g
Price
$16.66
Updated
2025/07/31
TCI Chemical
Product number
B2007
Product name
1-Bromo-3-(trifluoromethoxy)benzene
Purity
>98.0%(GC)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
B2007
Product name
1-Bromo-3-(trifluoromethoxy)benzene
Purity
>98.0%(GC)
Packaging
25g
Price
$60
Updated
2025/07/31
TRC
Product number
B695173
Product name
1-Bromo-3-(trifluoromethoxy)benzene
Packaging
5g
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-B-53
Product name
3-(Trifluoromethoxy)bromobenzene
Purity
99%
Packaging
100g
Price
$79
Updated
2021/12/16
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3-(Trifluoromethoxy)bromobenzene Chemical Properties,Usage,Production

Chemical Properties

Clear very faintly yellow liquid

Uses

1-Bromo-3-(trifluoromethoxy)benzene may be used in the preparation of 1,2-dehydro-3-(trifluoromethoxy)benzene. It may be used in the synthesis of new electronically deficient atropisomeric diphosphine ligand (S)-CF3O-BiPhep [2,2′-bis(diphenylphosphino)-6,6′-ditrifluoromethoxy-1,1′-biphenyl].

General Description

1-Bromo-3-(trifluoromethoxy)benzene undergoes Diels-Alder reaction with lithium diisopropylamide (LDA) in THF and furan, to yield the corresponding 1,4-dihydro-1,4-epoxy-5- or 6-(trifluoromethoxy)naphthalenes.

Synthesis

461-82-5

2252-44-0

The general procedure for the synthesis of 3-trifluoromethoxybromobenzene from p-trifluoromethoxyaniline is described below: Example 5 (comparative experiment) Preparation of 1-bromo-3-trifluoromethoxybenzene using bromine (Br2) in acetic acid medium. This was done as follows: 60 g of acetic acid was added to a 100 mL round bottom flask, followed by the slow addition of 30 g of 4-trifluoromethoxyaniline. After cooling the reaction mixture to 0-5 °C, 27 g of bromine was slowly added dropwise. Upon completion of the reaction, the reaction mixture was analyzed by gas chromatography, which showed 20% unreacted 4-trifluoromethoxyaniline, 37% monobrominated derivatives and more than 41% dibrominated derivatives.

References

[1] Patent: WO2007/107820, 2007, A2. Location in patent: Page/Page column 9
[2] Patent: WO2007/107820, 2007, A2. Location in patent: Page/Page column 9

3-(Trifluoromethoxy)bromobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(Trifluoromethoxy)bromobenzene Suppliers

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View Lastest Price from 3-(Trifluoromethoxy)bromobenzene manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-(Trifluoromethoxy)bromobenzene 2252-44-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-04
Speranza Chemical Co., Ltd.
Product
1-bromo-3-(trifluoromethoxy)benzene 2252-44-0
Price
US $160.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
300MT/year
Release date
2019-12-24
Henan Aochuang Chemical Co.,Ltd.
Product
3-(Trifluoromethoxy)bromobenzene 2252-44-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

2252-44-0, 3-(Trifluoromethoxy)bromobenzeneRelated Search:

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  • 3-Bromophenyl trifluoromethyl ether, 3-Bromo-alpha,alpha,alpha-trifluoroanisole
  • 3-(trifluoromrthoxy)bromobenzene
  • Inter-bromo-trifluoromethoxy benzene
  • Anisole, m-bromo-alphaalphaalpha-trifluoro-
  • BUTTPARK 91\57-27
  • M-BROMO(TRIFLUOROMETHOXY)BENZENE
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  • 1-BROMO-3-(TRIFLUOROMETHOXY)BENZENE 99%
  • 1-Bromo-3-(trifluoromethoxy)benzene, 98+%
  • 3-(Trifluoromethoxy)bromobenzene 99%
  • 3-(Trifluoromethoxy)bromobenzene99%
  • 1-BROMO-3-(TRIFLUOROMETHOXY)BENZENE / 3-BROMO-TRIFLUOROMETHOXYBENZENE
  • 3-(Trifluoromethoxy)bromobenzene,98+%
  • 1-Bromo-3-(trifluoromethoxy)benzene ,99%
  • 1-Bromo-3-(trifL
  • uoromethoxy)benzene
  • 1-Bromo-3-(trifluoromethoxy)benzene &gt
  • Benzene, 1-bromo-3-(trifluoromethoxy)-
  • 3-(Trifluoromethoxy)bromobenzene ISO 9001：2015 REACH
  • 3-(TRILFUOROMETHOXY)BROMOBENZENE
  • 2252-44-0
  • C7H4BrF3O
  • ARYL HALIDE
  • Building Blocks
  • Organic Building Blocks
  • Ethers
  • Oxygen Compounds
  • Fluorobenzene
  • Trifluoroanisole series
  • Aromatic Ethers
  • Halides
  • Phenyls & Phenyl-Het
  • Miscellaneous
  • Phenyls & Phenyl-Het
  • Ethers
  • Organic Building Blocks
  • Oxygen Compounds
  • alkyl bromide