2-Bromo-4-trifluoromethoxyaniline

Product Name: 2-Bromo-4-trifluoromethoxyaniline
CAS No.: 175278-17-8
Chemical Name: 2-Bromo-4-trifluoromethoxyaniline
Synonyms: 2-BROMO-4-(TRIFLUOROMETHOXY)ANILINE;BUTTPARK 83\07-26;2-Bromo-4-trifluorom;Liraglutide Impurity 05;Fluoroestradiol Impurity 28;2-Bromo-4-(trifluoeomethoxy)aniline;2-Bromo-4-(trifluoromethoxy)aniline98%;2-Bromo-4-(trifluoromethoxy)aniline 98%;2-Bromo-4-(trifluoromethoxy)aniline >Benzenamine, 2-bromo-4-(trifluoromethoxy)-
CBNumber: CB7210237
Molecular Formula: C7H5BrF3NO
Formula Weight: 256.02
MOL File: 175278-17-8.mol

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2-Bromo-4-trifluoromethoxyaniline Property

Boiling point:: 209 °C(lit.)
Density: 1.693 g/mL at 25 °C(lit.)
refractive index: n20/D 1.504(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Liquid
pka: 1.68±0.10(Predicted)
color: Clear light yellow to orange-yellow
Specific Gravity: 1.693
InChI: InChI=1S/C7H5BrF3NO/c8-5-3-4(1-2-6(5)12)13-7(9,10)11/h1-3H,12H2
InChIKey: ROSTYHNIIDIBEG-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(OC(F)(F)F)C=C1Br
CAS DataBase Reference: 175278-17-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Toxic
HazardClass: IRRITANT
HS Code: 29222990
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457388
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Purity: 98%
Packaging: 10g
Price: $22.3
Updated: 2025/07/31

TCI Chemical

Product number: B3799
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: B3799
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $152
Updated: 2025/07/31

TRC

Product number: B695148
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: B695148
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Packaging: 5g
Price: $55
Updated: 2021/12/16

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2-Bromo-4-trifluoromethoxyaniline Chemical Properties,Usage,Production

Chemical Properties

clear light yellow to orange-yellow liquid

Synthesis

461-82-5

175278-17-8

General procedure for the synthesis of 2-bromo-4-trifluoromethoxyaniline from 4-(trifluoromethoxy)aniline: N-bromosuccinimide (3.62 g, 20.34 mmol) was slowly added to a solution of 4-(trifluoromethoxy)aniline (3.00 g, 16.9 mmol) in acetonitrile (30 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by column chromatography using 10% ethyl acetate/hexane as eluent to give 2-bromo-4-trifluoromethoxyaniline as a brown oil (3.6 g, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 4.11 (broad single peak, 2H), 6.73 (double peak, 1H), 6.99 (double-double-heavy peak, 1H), and 7.31 (double-heavy peak, 1H).The LC-MS analysis showed that the [M-H]- peak was located at m/z 253.1.

References

[1] Patent: WO2015/100232, 2015, A2. Location in patent: Page/Page column 102
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 113 - 128
[3] Patent: EP1183229, 2005, B1. Location in patent: Page/Page column 143-144
[4] Organic Letters, 2011, vol. 13, # 20, p. 5636 - 5639
[5] Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13147 - 13150

2-Bromo-4-trifluoromethoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-4-trifluoromethoxyaniline Suppliers

Americas 1 Belgium 2 China 191 China Hong Kong 1 Europe 3 France 1 Germany 2 India 5 Italy 1 Japan 1 Switzerland 2 United Kingdom 20 United States 31 Global 261

Shanghai Harvest Chemical Industrial Co., Ltd.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Pure Chemistry Scientific Inc.

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View Lastest Price from 2-Bromo-4-trifluoromethoxyaniline manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Bromo-4-(trifluoromethoxy)aniline 175278-17-8
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

Career Henan Chemical Co

Product: 2-Bromo-4-trifluoromethoxyaniline 175278-17-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

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2-Bromo-4-(trifluoromethoxy)aniline 98%

2-Bromo-4-(trifluoromethoxy)aniline98%

2-BROMO-4-(TRIFLUOROMETHOXY)ANILINE

BUTTPARK 83\07-26

2-Bromo-4-(trifluoeomethoxy)aniline

2-Bromo-4-trifluorom

2-Bromo-4-(trifluoromethoxy)aniline &gt

Benzenamine, 2-bromo-4-(trifluoromethoxy)-

2-Bromo-4-trifluoromethoxyaniline ISO 9001：2015 REACH

Fluoroestradiol Impurity 28

Liraglutide Impurity 05

175278-17-8

75278-17-8

BrC6H3OCF3NH2

C7H5NOBrF3

Nitrogen Compounds

Organic Building Blocks

Amines

Building Blocks

C7

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Fluorine series

amine| alkyl bromide

blocks

Bromides

FluoroCompounds

NitroCompounds

Anilines, Aromatic Amines and Nitro Compounds

Amines

C7

Nitrogen Compounds