ChemicalBook > CAS DataBase List > 2-Bromo-4-trifluoromethoxyaniline

2-Bromo-4-trifluoromethoxyaniline

Product Name: 2-Bromo-4-trifluoromethoxyaniline
CAS No.: 175278-17-8
Chemical Name: 2-Bromo-4-trifluoromethoxyaniline
Synonyms: 2-BROMO-4-(TRIFLUOROMETHOXY)ANILINE;BUTTPARK 83\07-26;2-Bromo-4-trifluorom;Liraglutide Impurity 05;Fluoroestradiol Impurity 28;2-Bromo-4-(trifluoeomethoxy)aniline;2-Bromo-4-(trifluoromethoxy)aniline98%;2-Bromo-4-(trifluoromethoxy)aniline 98%;2-Bromo-4-(trifluoromethoxy)aniline >Benzenamine, 2-bromo-4-(trifluoromethoxy)-
CBNumber: CB7210237
Molecular Formula: C7H5BrF3NO
Formula Weight: 256.02
MOL File: 175278-17-8.mol

Less

2-Bromo-4-trifluoromethoxyaniline Property

Boiling point:: 209 °C(lit.)
Density: 1.693 g/mL at 25 °C(lit.)
refractive index: n20/D 1.504(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Liquid
pka: 1.68±0.10(Predicted)
color: Clear light yellow to orange-yellow
Specific Gravity: 1.693
InChI: InChI=1S/C7H5BrF3NO/c8-5-3-4(1-2-6(5)12)13-7(9,10)11/h1-3H,12H2
InChIKey: ROSTYHNIIDIBEG-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(OC(F)(F)F)C=C1Br
CAS DataBase Reference: 175278-17-8(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Toxic
HazardClass: IRRITANT
HS Code: 29222990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457388
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Purity: 98%
Packaging: 10g
Price: $22.3
Updated: 2025/07/31

TCI Chemical

Product number: B3799
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: B3799
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $152
Updated: 2025/07/31

TRC

Product number: B695148
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: B695148
Product name: 2-Bromo-4-(trifluoromethoxy)aniline
Packaging: 5g
Price: $55
Updated: 2021/12/16

Less

2-Bromo-4-trifluoromethoxyaniline Chemical Properties,Usage,Production

Chemical Properties

clear light yellow to orange-yellow liquid

Synthesis

461-82-5

175278-17-8

General procedure for the synthesis of 2-bromo-4-trifluoromethoxyaniline from 4-(trifluoromethoxy)aniline: N-bromosuccinimide (3.62 g, 20.34 mmol) was slowly added to a solution of 4-(trifluoromethoxy)aniline (3.00 g, 16.9 mmol) in acetonitrile (30 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by column chromatography using 10% ethyl acetate/hexane as eluent to give 2-bromo-4-trifluoromethoxyaniline as a brown oil (3.6 g, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 4.11 (broad single peak, 2H), 6.73 (double peak, 1H), 6.99 (double-double-heavy peak, 1H), and 7.31 (double-heavy peak, 1H).The LC-MS analysis showed that the [M-H]- peak was located at m/z 253.1.

References

[1] Patent: WO2015/100232, 2015, A2. Location in patent: Page/Page column 102
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 113 - 128
[3] Patent: EP1183229, 2005, B1. Location in patent: Page/Page column 143-144
[4] Organic Letters, 2011, vol. 13, # 20, p. 5636 - 5639
[5] Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13147 - 13150

2-Bromo-4-trifluoromethoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Bromo-4-trifluoromethoxyaniline Suppliers

Americas 1 Belgium 2 China 190 China Hong Kong 1 Europe 3 France 1 Germany 2 India 5 Italy 1 Japan 1 Switzerland 2 United Kingdom 20 United States 31 Global 260

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Beijing Eternalchem Co,. Ltd.

Tel: 010-59484199 18611897322
Email: sales@eternalchem.com
Country: China
ProdList: 4383
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 3997
Advantage: 55

Tianjin Jinyuda Chemical Co., Ltd.

Tel: 022-58013646 13011382049
Fax: 022-23854368
Email: sales@jinyudachem.com
Country: China
ProdList: 1930
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Candia Thamtech Company Limited

Tel: 0371-86615086 18203638366 0371-86159066 13526786601
Fax: 0371-86159066
Country: China
ProdList: 2015
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai GaoLang Chemical Technology Co., Ltd.

Tel: 021-57340939 18017297327
Fax: 021-37210791
Email: sales@gaolangchemical.com
Country: China
ProdList: 892
Advantage: 55

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2790
Advantage: 52

Shanghai Jovan Biochemical Technology Co. Ltd.

Tel: +86-021-61654350
Fax: +86-021-61654350
Email: 1245958370@qq.com
Country: China
ProdList: 2982
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

shanghai sinofluoro chemicals co., ltd.

Tel: 15800445152
Fax: 021-64278603
Email: sales@sinofluoro.com
Country: China
ProdList: 297
Advantage: 59

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Nanjing ERan Biological Pharmaceutical Co., Ltd.

Tel: 13770809694
Fax: +86 25 56203983
Email: googlexu_0114@sina.com
Country: China
ProdList: 990
Advantage: 58

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 3909
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Beijing Hechemist Technology CO.,LTD

Tel: 18511709189
Fax: 010-58043593
Email: sales@hechemist.com
Country: China
ProdList: 2835
Advantage: 58

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Less

View Lastest Price from 2-Bromo-4-trifluoromethoxyaniline manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Bromo-4-(trifluoromethoxy)aniline 175278-17-8
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

Career Henan Chemical Co

Product: 2-Bromo-4-trifluoromethoxyaniline 175278-17-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

175278-17-8, 2-Bromo-4-trifluoromethoxyanilineRelated Search:

(Trifluoromethoxy)benzene 4'-(Trifluoromethoxy)acetophenone 2-Bromoaniline 2-Aminobenzotrifluoride 4-(Trifluoromethoxy)chlorobenzene 4-Aminobenzotrifluoride Aniline p-Anisaldehyde Anisole 3-Methoxyacetophenone 4-Bromoaniline p-Anisidine 4-Methoxybenzyl alcohol 4-Methoxybenzyl cyanide 4-Methoxybenzoyl chloride p-Trifluoromethoxy phenol o-Anisidine ANILINE BLACK

2-Bromo-4-(trifluoromethoxy)aniline 98%

2-Bromo-4-(trifluoromethoxy)aniline98%

2-BROMO-4-(TRIFLUOROMETHOXY)ANILINE

BUTTPARK 83\07-26

2-Bromo-4-(trifluoeomethoxy)aniline

2-Bromo-4-trifluorom

2-Bromo-4-(trifluoromethoxy)aniline &gt

Benzenamine, 2-bromo-4-(trifluoromethoxy)-

2-Bromo-4-trifluoromethoxyaniline ISO 9001：2015 REACH

Fluoroestradiol Impurity 28

Liraglutide Impurity 05

175278-17-8

75278-17-8

BrC6H3OCF3NH2

C7H5NOBrF3

Nitrogen Compounds

Organic Building Blocks

Amines

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Fluorine series

amine| alkyl bromide

blocks

Bromides

FluoroCompounds

NitroCompounds

Anilines, Aromatic Amines and Nitro Compounds

Amines

Nitrogen Compounds