4-Bromoanisole

Product Name: 4-Bromoanisole
CAS No.: 104-92-7
Chemical Name: 4-Bromoanisole
Synonyms: 1-BROMO-4-METHOXYBENZENE;P-BROMOANISOLE;2-Bromoanisole,98%;4-Bromoanisole,98%;1-bromo-4-methoxy-benzen;4-Bromoanisole,1-Bromo-4-methoxybenzene;p-Bromanisole;p-bromoanisol;Anisyl bromide;p-bromo-anisol
CBNumber: CB2223135
Molecular Formula: C7H7BrO
Formula Weight: 187.03
MOL File: 104-92-7.mol

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4-Bromoanisole Property

Melting point:: 9-10 °C (lit.)
Boiling point:: 223 °C (lit.)
Density: 1.494 g/mL at 25 °C (lit.)
refractive index: n20/D 1.564(lit.)
Flash point:: 202 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
form: Liquid
color: Clear colorless to slightly yellow
Water Solubility: immiscible
Merck: 14,1428
BRN: 1237590
Dielectric constant: 7.4000000000000004
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: QJPJQTDYNZXKQF-UHFFFAOYSA-N
CAS DataBase Reference: 104-92-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1-bromo-4-methoxy-(104-92-7)
EPA Substance Registry System: Benzene, 1-bromo-4-methoxy- (104-92-7)

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Safety

Hazard Codes: Xn
Safety Statements: 23-24/25
WGK Germany: 2
RTECS: BZ8501000
F: 8
TSCA: Yes
HS Code: 29093038
Toxicity: LD50 orl-mus: 2200 mg/kg GISAAA 44(12),19,79

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B56501
Product name: 4-Bromoanisole
Purity: ≥99.0%
Packaging: 50g
Price: $40.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: B56501
Product name: 4-Bromoanisole
Purity: ≥99.0%
Packaging: 100g
Price: $53.6
Updated: 2024/03/01

TCI Chemical

Product number: B0547
Product name: 4-Bromoanisole
Purity: >97.0%(GC)
Packaging: 25g
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: B0547
Product name: 4-Bromoanisole
Purity: >97.0%(GC)
Packaging: 100g
Price: $34
Updated: 2024/03/01

Alfa Aesar

Product number: A11824
Product name: 4-Bromoanisole, 99%
Packaging: 100g
Price: $46.4
Updated: 2024/03/01

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4-Bromoanisole Chemical Properties,Usage,Production

Chemical Properties

4-Bromoanisole is a colourless to pale yellow oily liquid with a pleasant smell similar to that of anise seed. Insoluble in water, soluble in ethanol, ether and chloroform. It is one of three isomers of bromoanisole, the others being 3-bromoanisole and 2-bromoanisole. It is the precursor to many 4-anisyl derivatives.

Uses

4-Bromoanisole finds application as an intermediate in synthetic chemistry. It is used in the preparation of aryl 1,3-diketones and ethyl 4-methoxycinnamate. It is a used as a brominating reagent. Further, it is used in Suzuki coupling reaction with phenylboronic acid as well as in Heck reaction.

Preparation

4-Bromoanisole is obtained by reacting p-bromophenol with dimethyl sulfate.

Definition

ChEBI: 4-bromoanisole is a monomethoxybenzene carrying a bromo substituent at position 4. It is a monomethoxybenzene and an organobromine compound.

Biological Functions

4-Bromoanisole is compound sometimes used in RNA extraction which serves to further eliminate DNA contamination. It interacts with genomic DNA(gDNA) and through a separation phase, it will be located in the organic layer instead of the aqueous layer (upper layer) containing the RNA extract.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7429, 1994 DOI: 10.1016/0040-4039(94)85333-9
Synthesis, p. 868, 1986 DOI: 10.1055/s-1986-31813

General Description

4-Bromoanisole is a useful brominating reagent. It is formed as reaction product in the reaction between HOBr and anisole. Suzuki coupling of 4-bromoanisole with phenylboronic acid catalyzed by palladium pincer complexes has been studied. Heck Reaction of 4-bromoanisole with ethyl acrylates in room-temperature ionic liquids is reported to afford ethyl 4-methoxycinnamate.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits toxic vapors of Br^-.

Purification Methods

Crystallise the anisole by repeated partial freezing, then distil it under reduced pressure. [Beilstein 6 III 741, 6 IV 1044.]

4-Bromoanisole Preparation Products And Raw materials

Raw materials

Extractant Anisole 4-Bromophenol Government regulation Dimethyl ether Dimethyl sulfate

Preparation Products

cis-Anethol 4-(IMIDAZOL-1-YL)PHENOL TRIS(4-HYDROXYPHENYL)PHOSPHINE OXIDE (4-METHOXYPHENYL)-BORANE 4-Methoxytriphenylmethyl chloride

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4-Bromoanisole Suppliers

Americas 1 Belgium 2 Canada 5 China 305 China Hong Kong 1 Cyprus 1 Europe 4 France 1 Germany 9 India 78 Israel 3 Japan 9 Poland 2 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 2 Ukraine 2 United Kingdom 18 United States 53 Global 502

Sanmenxia Aoke Chemical Industry Co., Ltd.

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yxinchem

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INTATRADE GmbH

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 4-Bromoanisole manufacturers

Yancheng Longshen Chemical Co.,Ltd.

Product: 4-Bromoanisole 104-92-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%GC
Supply Ability: 20 tons
Release date: 2023-10-09

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Bromoanisole 104-92-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-03

Qingdao RENAS Polymer Material Co., Ltd.

Product: 4-Bromoanisole 104-92-7
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-09-03

104-92-7, 4-BromoanisoleRelated Search:

4-Methoxyphenol 4-Methoxyphenylacetic acid 1,3-Dibromobenzene 1,2-Dibromobenzene Anise oil Bromoxynil 4-Methoxybenzoic acid 4'-Bromopropiophenone Anisole Thioanisole (Trifluoromethoxy)benzene Tetrabromobisphenol A bis(dibromopropyl ether) m-Anisyl alcohol Decabromodiphenyl oxide 4-Bromobenzaldehyde 4-Methoxybenzyl alcohol 2-Bromobenzonitrile o-Anisaldehyde

p-methoxyphenylbromide

2-Bromoanisole,98%

4-Bromomethoxybenzene

4-Methoxy-1-bromobenzene

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p-Anisyl bromide

p-anisylbromide

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p-bromoanisol

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p-Bromophenyl methyl ether

para-BROMOANISOLE

4-BROMO ANISOLE 99%MIN

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p-BroMophenol Methyl ether

4-BroMoanisole, 98% 100ML

4-BROMOANISOLE FOR SYNTHESIS 100 ML

4-BROMOANISOLE FOR SYNTHESIS 250 ML

4-BroMoanisole >=99.0%

The broMobenzene Methyl ether

BROMOANISOLE(4-)

1-BROMO-4-METHOXYBENZENE

4-Bromoanisole≥ 99% (GC)

4-BROMO ANISOL

4-BROMOANISOLE

P-BROMOANISOLE

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p-bromophenylmethylether

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4-Bromoanisole (p-Methoxyphenyl Bromide)

4-Bromoanisole,99%

Para Bromo Anisole (PBA) (Campaign base)

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PARA BROMO ANISOLE/ ALKYL BROMIDE

P-bromophenyl ether

4-Bromoanisole 98% For Synthesis

104-92-7

104-92-2

102-92-7

Building Blocks

Organic Building Blocks

Oxygen Compounds

ARYL HALIDE

Ethers

Anisoles, Alkyloxy Compounds & Phenylacetates

Bromine Compounds

alkyl bromide

Anisole