4-Bromoanisole

Product Name: 4-Bromoanisole
CAS No.: 104-92-7
Chemical Name: 4-Bromoanisole
Synonyms: 1-BROMO-4-METHOXYBENZENE;P-BROMOANISOLE;2-Bromoanisole,98%;4-Bromoanisole,98%;1-bromo-4-methoxy-benzen;4-Bromoanisole,1-Bromo-4-methoxybenzene;p-Bromanisole;p-bromoanisol;Anisyl bromide;p-bromo-anisol
CBNumber: CB2223135
Molecular Formula: C7H7BrO
Formula Weight: 187.03
MOL File: 104-92-7.mol

More

Less

4-Bromoanisole Property

Melting point:: 9-10 °C (lit.)
Boiling point:: 223 °C (lit.)
Density: 1.494 g/mL at 25 °C (lit.)
refractive index: n20/D 1.564(lit.)
Flash point:: 202 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
form: Liquid
color: Clear colorless to slightly yellow
Water Solubility: immiscible
Merck: 14,1428
BRN: 1237590
Dielectric constant: 7.4000000000000004
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: QJPJQTDYNZXKQF-UHFFFAOYSA-N
CAS DataBase Reference: 104-92-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1-bromo-4-methoxy-(104-92-7)
EPA Substance Registry System: Benzene, 1-bromo-4-methoxy- (104-92-7)

More

Less

Safety

Hazard Codes: Xn
Safety Statements: 23-24/25
WGK Germany: 2
RTECS: BZ8501000
F: 8
TSCA: Yes
HS Code: 29093038
Toxicity: LD50 orl-mus: 2200 mg/kg GISAAA 44(12),19,79

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B56501
Product name: 4-Bromoanisole
Purity: ≥99.0%
Packaging: 50g
Price: $40.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: B56501
Product name: 4-Bromoanisole
Purity: ≥99.0%
Packaging: 100g
Price: $53.6
Updated: 2024/03/01

TCI Chemical

Product number: B0547
Product name: 4-Bromoanisole
Purity: >97.0%(GC)
Packaging: 25g
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: B0547
Product name: 4-Bromoanisole
Purity: >97.0%(GC)
Packaging: 100g
Price: $34
Updated: 2024/03/01

Alfa Aesar

Product number: A11824
Product name: 4-Bromoanisole, 99%
Packaging: 100g
Price: $46.4
Updated: 2024/03/01

More

Less

4-Bromoanisole Chemical Properties,Usage,Production

Chemical Properties

4-Bromoanisole is a colourless to pale yellow oily liquid with a pleasant smell similar to that of anise seed. Insoluble in water, soluble in ethanol, ether and chloroform. It is one of three isomers of bromoanisole, the others being 3-bromoanisole and 2-bromoanisole. It is the precursor to many 4-anisyl derivatives.

Uses

4-Bromoanisole finds application as an intermediate in synthetic chemistry. It is used in the preparation of aryl 1,3-diketones and ethyl 4-methoxycinnamate. It is a used as a brominating reagent. Further, it is used in Suzuki coupling reaction with phenylboronic acid as well as in Heck reaction.

Preparation

4-Bromoanisole is obtained by reacting p-bromophenol with dimethyl sulfate.

Definition

ChEBI: 4-bromoanisole is a monomethoxybenzene carrying a bromo substituent at position 4. It is a monomethoxybenzene and an organobromine compound.

Biological Functions

4-Bromoanisole is compound sometimes used in RNA extraction which serves to further eliminate DNA contamination. It interacts with genomic DNA(gDNA) and through a separation phase, it will be located in the organic layer instead of the aqueous layer (upper layer) containing the RNA extract.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7429, 1994 DOI: 10.1016/0040-4039(94)85333-9
Synthesis, p. 868, 1986 DOI: 10.1055/s-1986-31813

General Description

4-Bromoanisole is a useful brominating reagent. It is formed as reaction product in the reaction between HOBr and anisole. Suzuki coupling of 4-bromoanisole with phenylboronic acid catalyzed by palladium pincer complexes has been studied. Heck Reaction of 4-bromoanisole with ethyl acrylates in room-temperature ionic liquids is reported to afford ethyl 4-methoxycinnamate.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits toxic vapors of Br^-.

Purification Methods

Crystallise the anisole by repeated partial freezing, then distil it under reduced pressure. [Beilstein 6 III 741, 6 IV 1044.]

4-Bromoanisole Preparation Products And Raw materials

Raw materials

Extractant Anisole 4-Bromophenol Government regulation Dimethyl ether Dimethyl sulfate

Preparation Products

cis-Anethol 4-(IMIDAZOL-1-YL)PHENOL TRIS(4-HYDROXYPHENYL)PHOSPHINE OXIDE (4-METHOXYPHENYL)-BORANE 4-Methoxytriphenylmethyl chloride

More

Less

4-Bromoanisole Suppliers

Americas 1 Belgium 2 Canada 5 China 296 China Hong Kong 1 Cyprus 1 Europe 4 France 1 Germany 9 India 77 Israel 3 Japan 9 Poland 2 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 2 Ukraine 2 United Kingdom 18 United States 53 Global 492

yxinchem

Tel: +86-0710-4323688 +86-18071785587
Fax: 15502706050
Email: market@yxinchem.com
Country: China
ProdList: 1022
Advantage: 58

BeiJing Greenchem Technology Co.,Ltd.

Tel: 13842764302; 13842764302
Fax: 010-62925455
Email: chemrocking@bjgreenchem.com
Country: China
ProdList: 461
Advantage: 58

Changzhou Pumelo Co.,Ltd.

Tel: 0519-81698808 13809072999
Fax: 0519-81698098
Email: pml@pmlchem.com
Country: China
ProdList: 59
Advantage: 55

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3576
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Beijing dtftchem Technology Co., Ltd.

Tel: 010-60275820 13031183356
Fax: 010-60270825
Email: elainezt@sina.com
Country: China
ProdList: 1392
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

More

Less

View Lastest Price from 4-Bromoanisole manufacturers

Yancheng Longshen Chemical Co.,Ltd.

Product: 4-Bromoanisole 104-92-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%GC
Supply Ability: 20 tons
Release date: 2023-10-09

Hebei Duling International Trade Co. LTD

Product: 4-Bromoanisole 104-92-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Ton
Release date: 2023-02-15

Hebei Guanlang Biotechnology Co., Ltd.

Product: 4-Bromoanisole 104-92-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2023-02-24

104-92-7, 4-BromoanisoleRelated Search:

4-Methoxyphenol 4-Methoxyphenylacetic acid 1,3-Dibromobenzene 1,2-Dibromobenzene Anise oil Bromoxynil 4-Methoxybenzoic acid 4'-Bromopropiophenone Anisole Thioanisole (Trifluoromethoxy)benzene Tetrabromobisphenol A bis(dibromopropyl ether) m-Anisyl alcohol Decabromodiphenyl oxide 4-Bromobenzaldehyde 4-Methoxybenzyl alcohol 2-Bromobenzonitrile o-Anisaldehyde

p-methoxyphenylbromide

2-Bromoanisole,98%

4-Bromomethoxybenzene

4-Methoxy-1-bromobenzene

4-Methoxybromobenzene

4-Methoxyphenyl bromide

4-methoxyphenylbromide

Anisole, p-bromo-

Anisyl bromide

Benzene,1-bromo-4-methoxy-

p-Anisyl bromide

p-anisylbromide

p-Bromanisole

p-bromoanisol

p-bromo-anisol

p-Bromophenyl methyl ether

para-BROMOANISOLE

4-BROMO ANISOLE 99%MIN

Bromophenol methyl ether

4-Bromoanisole,98%

4-Bromoanisole,1-Bromo-4-methoxybenzene

Of BroMoanisole

p-BroMophenol Methyl ether

4-BroMoanisole, 98% 100ML

4-BROMOANISOLE FOR SYNTHESIS 100 ML

4-BROMOANISOLE FOR SYNTHESIS 250 ML

4-BroMoanisole >=99.0%

The broMobenzene Methyl ether

BROMOANISOLE(4-)

1-BROMO-4-METHOXYBENZENE

4-Bromoanisole≥ 99% (GC)

4-BROMO ANISOL

4-BROMOANISOLE

P-BROMOANISOLE

1-bromo-4-methoxy-benzen

p-bromophenylmethylether

p-Methoxybromobenzene

p-Methoxyphenyl bromide

4-Bromoanisole &gt

4-Bromoanisole (p-Methoxyphenyl Bromide)

4-Bromoanisole,99%

Para Bromo Anisole (PBA) (Campaign base)

4-Bromoanisole pure, 98%

PARA BROMO ANISOLE/ ALKYL BROMIDE

P-bromophenyl ether

104-92-7

104-92-2

102-92-7

Building Blocks

Organic Building Blocks

Oxygen Compounds

ARYL HALIDE

Ethers

Anisoles, Alkyloxy Compounds & Phenylacetates

Bromine Compounds

alkyl bromide

Anisole

AnisoleSeries