ChemicalBook > CAS DataBase List > 4-Bromoanisole
4-Bromoanisole
- Product Name
- 4-Bromoanisole
- CAS No.
- 104-92-7
- Chemical Name
- 4-Bromoanisole
- Synonyms
- 1-BROMO-4-METHOXYBENZENE;P-BROMOANISOLE;2-Bromoanisole,98%;4-Bromoanisole,98%;1-bromo-4-methoxy-benzen;4-Bromoanisole,1-Bromo-4-methoxybenzene;p-Bromanisole;p-bromoanisol;Anisyl bromide;p-bromo-anisol
- CBNumber
- CB2223135
- Molecular Formula
- C7H7BrO
- Formula Weight
- 187.03
- MOL File
- 104-92-7.mol
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4-Bromoanisole Property
- Melting point:
- 9-10 °C (lit.)
- Boiling point:
- 223 °C (lit.)
- Density
- 1.494 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.564(lit.)
- Flash point:
- 202 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Liquid
- color
- Clear colorless to slightly yellow
- Water Solubility
- immiscible
- Merck
- 14,1428
- BRN
- 1237590
- Dielectric constant
- 7.4000000000000004
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- QJPJQTDYNZXKQF-UHFFFAOYSA-N
- CAS DataBase Reference
- 104-92-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1-bromo-4-methoxy-(104-92-7)
- EPA Substance Registry System
- Benzene, 1-bromo-4-methoxy- (104-92-7)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- B56501
- Product name
- 4-Bromoanisole
- Purity
- ≥99.0%
- Packaging
- 50g
- Price
- $40.1
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- B56501
- Product name
- 4-Bromoanisole
- Purity
- ≥99.0%
- Packaging
- 100g
- Price
- $53.6
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B0547
- Product name
- 4-Bromoanisole
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $18
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B0547
- Product name
- 4-Bromoanisole
- Purity
- >97.0%(GC)
- Packaging
- 100g
- Price
- $34
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A11824
- Product name
- 4-Bromoanisole, 99%
- Packaging
- 100g
- Price
- $46.4
- Updated
- 2024/03/01
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4-Bromoanisole Chemical Properties,Usage,Production
Chemical Properties
4-Bromoanisole is a colourless to pale yellow oily liquid with a pleasant smell similar to that of anise seed. Insoluble in water, soluble in ethanol, ether and chloroform. It is one of three isomers of bromoanisole, the others being 3-bromoanisole and 2-bromoanisole. It is the precursor to many 4-anisyl derivatives.
Uses
4-Bromoanisole finds application as an intermediate in synthetic chemistry. It is used in the preparation of aryl 1,3-diketones and ethyl 4-methoxycinnamate. It is a used as a brominating reagent. Further, it is used in Suzuki coupling reaction with phenylboronic acid as well as in Heck reaction.
Preparation
4-Bromoanisole is obtained by reacting p-bromophenol with dimethyl sulfate.
Definition
ChEBI: 4-bromoanisole is a monomethoxybenzene carrying a bromo substituent at position 4. It is a monomethoxybenzene and an organobromine compound.
Biological Functions
4-Bromoanisole is compound sometimes used in RNA extraction which serves to further eliminate DNA contamination. It interacts with genomic DNA(gDNA) and through a separation phase, it will be located in the organic layer instead of the aqueous layer (upper layer) containing the RNA extract.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 7429, 1994 DOI: 10.1016/0040-4039(94)85333-9
Synthesis, p. 868, 1986 DOI: 10.1055/s-1986-31813
General Description
4-Bromoanisole is a useful brominating reagent. It is formed as reaction product in the reaction between HOBr and anisole. Suzuki coupling of 4-bromoanisole with phenylboronic acid catalyzed by palladium pincer complexes has been studied. Heck Reaction of 4-bromoanisole with ethyl acrylates in room-temperature ionic liquids is reported to afford ethyl 4-methoxycinnamate.
Safety Profile
Moderately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits toxic vapors of Br-.
Purification Methods
Crystallise the anisole by repeated partial freezing, then distil it under reduced pressure. [Beilstein 6 III 741, 6 IV 1044.]
4-Bromoanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromoanisole manufacturers
Yancheng Longshen Chemical Co.,Ltd.
- Product
- 4-Bromoanisole 104-92-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%GC
- Supply Ability
- 20 tons
- Release date
- 2023-10-09
Hebei Duling International Trade Co. LTD
- Product
- 4-Bromoanisole 104-92-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Ton
- Release date
- 2023-02-15
Hebei Guanlang Biotechnology Co., Ltd.
- Product
- 4-Bromoanisole 104-92-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-02-24
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