4-(IMIDAZOL-1-YL)PHENOL
- Product Name
- 4-(IMIDAZOL-1-YL)PHENOL
- CAS No.
- 10041-02-8
- Chemical Name
- 4-(IMIDAZOL-1-YL)PHENOL
- Synonyms
- Compound Fr16629;p-imidazo-1-ylphenol;4-(IMIDAZOL-1-YL)PHENO;P-(1-IMIDAZOLYL)PHENOL;LABOTEST-BB LT00440917;-(IMIDAZOL-1-YL)PHENOL;4-(1-Imidazolyl)phenol;4-(IMIDAZOL-1-YL)PHENOL;p-(Imidazol-1-yl) phenol;4-(1H-IMIDAZOL-1-YL)PHENOL
- CBNumber
- CB1391497
- Molecular Formula
- C9H8N2O
- Formula Weight
- 160.17
- MOL File
- 10041-02-8.mol
4-(IMIDAZOL-1-YL)PHENOL Property
- Melting point:
- 204-206 °C(lit.)
- Boiling point:
- 286.07°C (rough estimate)
- Density
- 1.1846 (rough estimate)
- refractive index
- 1.5570 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Fine Crystalline Powder
- pka
- 9.36±0.26(Predicted)
- color
- Light brown-gray to brown-beige
- BRN
- 509999
- InChI
- InChI=1S/C9H8N2O/c12-9-3-1-8(2-4-9)11-6-5-10-7-11/h1-7,12H
- InChIKey
- CYKCUAPYWQDIKR-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(N2C=NC=C2)C=C1
- CAS DataBase Reference
- 10041-02-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-22
- WGK Germany
- 3
- HS Code
- 29332990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 183725
- Product name
- 4-(Imidazol-1-yl)phenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $41.7
- Updated
- 2025/07/31
- Product number
- I1143
- Product name
- 4-(1H-Imidazol-1-yl)phenol
- Packaging
- 1G
- Price
- $119
- Updated
- 2025/07/31
- Product number
- I1143
- Product name
- 4-(1H-Imidazol-1-yl)phenol
- Packaging
- 5G
- Price
- $357
- Updated
- 2025/07/31
- Product number
- OR2614
- Product name
- 4-(1H-Imidazol-1-yl)phenol
- Purity
- 99%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4H01-1-94
- Product name
- 4-(1H-Imidazol-1-yl)phenol
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
4-(IMIDAZOL-1-YL)PHENOL Chemical Properties,Usage,Production
Chemical Properties
ligth brown-grey to brown-beige fine cryst. powder
Uses
4-(Imidazol-1-yl)phenol was used in evaluation of estrogenicity of phenolic xenoestrogens by Saccharomyces cerevisiae-based Lac-Z reporter assay.
Synthesis
1) In the reactor, add 1kg p-bromoanisole, 0.5kg imidazole, 70g cuprous oxide, 1kg potassium carbonate and 2LNMP, stirring. The reaction temperature was raised to 120??C, and the reaction was carried out for 12 h. At the end of the reaction, it was filtered, and 500 ml of ethyl acetate washed to remove the solid; 2L of 8 % NaOH aqueous solution was added, stirred, and a solid was produced, and the solid was removed by filtration. To the liquid, ethyl acetate (3x1L) was added to extract, and the organic phases were combined. To the organic phase, saturated saline was added, stirred, partitioned, dried, spun off the solvent, and recrystallized using methyl tert-butyl ether to give 1-(4-methoxyphenyl) -1H-imidazole 500g; yield 53%;
2) In a reactor, add 0.5kg of 1-(4-methoxyphenyl)-1H-imidazole that dissolved in dichloromethane, stirring, ice salt bath to cool the system to 0 ??, nitrogen protection, dropwise addition of 4.3L1.0M BBr3 dichloromethane solution. After dropping, the reaction system was naturally warmed to 25??C and reacted for 12 h. At the end of the reaction, the reaction solution was slowly added to an ice-water mixture and quenched. Sodium bicarbonate adjusted the base, precipitated white solid, filtered, using tert-butyl alcohol recrystallization to get 4-(imidazol-1-yl)phenol 350g; yield 76%, purity 99.8%.
4-(IMIDAZOL-1-YL)PHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(IMIDAZOL-1-YL)PHENOL manufacturers
- Product
- -(IMIDAZOL-1-YL)PHENOL 10041-02-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24