3-(DIFLUOROMETHOXY)BROMOBENZENE
- Product Name
- 3-(DIFLUOROMETHOXY)BROMOBENZENE
- CAS No.
- 262587-05-3
- Chemical Name
- 3-(DIFLUOROMETHOXY)BROMOBENZENE
- Synonyms
- 1-BROMO-3-(DIFLUOROMETHOXY)BENZENE;Jrd-0474;(Difluoromethoxy)bromobenzene;3-(DIFLUOROMETHOXY)BROMOBENZENE;3-BroMo-1-(difluoroMethoxy)benzene;Inter-bromo-difluoromethoxybenzene;Benzene, 1-bromo-3-(difluoromethoxy)-;1-Bromo-3-(difluoromethoxy)benzene >
- CBNumber
- CB9279010
- Molecular Formula
- C7H5BrF2O
- Formula Weight
- 223.01
- MOL File
- 262587-05-3.mol
3-(DIFLUOROMETHOXY)BROMOBENZENE Property
- Boiling point:
- 196-197 °C(lit.)
- Density
- 1.585 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.502(lit.)
- Flash point:
- 199 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow
- InChI
- 1S/C7H5BrF2O/c8-5-2-1-3-6(4-5)11-7(9)10/h1-4,7H
- InChIKey
- NWBDGKNKAFGQQL-UHFFFAOYSA-N
- SMILES
- FC(F)Oc1cccc(Br)c1
- CAS DataBase Reference
- 262587-05-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 553433
- Product name
- 1-Bromo-3-(difluoromethoxy)benzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $65
- Updated
- 2023/06/20
- Product number
- B4189
- Product name
- 1-Bromo-3-(difluoromethoxy)benzene
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $50
- Updated
- 2022/04/27
- Product number
- B4189
- Product name
- 1-Bromo-3-(difluoromethoxy)benzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- B690148
- Product name
- 1-Bromo-3-(difluoromethoxy)benzene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 006010
- Product name
- 3-(Difluoromethoxy)bromobenzene
- Packaging
- 25g
- Price
- $99
- Updated
- 2021/12/16
3-(DIFLUOROMETHOXY)BROMOBENZENE Chemical Properties,Usage,Production
Chemical Properties
liquid
Synthesis
591-20-8
1895-39-2
262587-05-3
1. In a dry reaction flask, 3-bromophenol (1.28 g, 7.39 mmol) was dissolved in DMF (12.0 mL). 2. Sodium 2-chloro-2,2-difluoroacetate (2.82 g, 18.49 mmol) and Cs2CO3 (4.82 g, 14.79 mmol) were added sequentially. 3. the reaction mixture was heated to 100 °C. Note that gas is released during the reaction and caution should be exercised. 4. After 2 hours of reaction, cool to room temperature and dilute the reaction mixture with EtOAc. 5. 5. Wash the organic layer with water and brine, and then extract the aqueous phase with EtOAc three times. 6. 6. All organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. 7. The crude product was purified by silica gel column chromatography (eluent: 0-5% EtOAc in hexane solution) to afford the target compound T18.1 as an oil in 61% yield. The product could be used in the next reaction without further purification.
References
[1] Patent: WO2010/45258, 2010, A2. Location in patent: Page/Page column 179; 180
[2] Patent: WO2009/111056, 2009, A1. Location in patent: Page/Page column 151-152
3-(DIFLUOROMETHOXY)BROMOBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(DIFLUOROMETHOXY)BROMOBENZENE manufacturers
- Product
- 3-(DIFLUOROMETHOXY)BROMOBENZENE 262587-05-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-30