2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
- Product Name
- 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
- CAS No.
- 335654-06-3
- Chemical Name
- 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
- Synonyms
- SW-114;SWF-114;2-CHLORO-7H-PYRROLO[2;2-Chloro-7-deazapurine;2-Chloro-7H-pyrrolo[2,3-d...;2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;2-Chloro-1H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyriMidine,2-chloro-;1H-Pyrrolo[2,3-d]pyrimidine, 2-chloro-;2-Chloro-7H-pyrrolo[2,3-d]pyrimidine 95%
- CBNumber
- CB6385730
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 335654-06-3.mol
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Property
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 11.18±0.50(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C6H4ClN3/c7-6-9-3-4-1-2-8-5(4)10-6/h1-3H,(H,8,9,10)
- InChIKey
- HJOQGBBHVRYTDX-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C2C=CNC2=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ANV00113
- Product name
- 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- C379895
- Product name
- 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 2.5g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC11980
- Product name
- 2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- C12477
- Product name
- 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 98%
- Packaging
- 25g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 067058
- Product name
- 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 95%
- Packaging
- 5g
- Price
- $98
- Updated
- 2021/12/16
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production
Uses
An intermediate pyrrolo-pyrimidine compound used in the preparation of tyrosine kinase inhibitors, particularly oral signal transducers and activators of transcription 6 (STAT6) inhibitors.
Uses
An intermediate pyrrolo-pyrimidine compound, 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine can be used in the preparation of tyrosine kinase inhibitors, particularly oral signal transducers and activators of transcription 6 (STAT6) inhibitors.
Synthesis
90213-66-4
335654-06-3
The general procedure for the synthesis of 2-chloro-7H-pyrrolo[2,3-d]pyrimidines from 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidines is as follows: zinc powder (8700.0 g, 133 mol, 10.0 eq.) was added in batches to glacial acetic acid (3.3 L, 53.2 mol, 4.0 eq.), followed by addition of acetonitrile (30.0 L) to form a reaction mixture. The reaction mixture was cooled to 25 °C and then filtered. The filtrate was concentrated under reduced pressure and then added to 30 L of ice water to precipitate the product. The mixture was warmed to 80 °C and kept at this temperature for 14 hours. Upon completion of the reaction, a pink solid was obtained. The solid was collected by filtration and the cake was washed with water (5 L x 3 times) and dried to give 1501.7 g of white solid in 73.54% yield.
References
[1] Patent: CN105949196, 2016, A. Location in patent: Paragraph 0044; 0065; 0083-0087
[2] Patent: CN105859726, 2016, A. Location in patent: Paragraph 0030; 0031; 0032
[3] Patent: WO2010/7116, 2010, A2. Location in patent: Page/Page column 91-92
[4] Patent: WO2010/7114, 2010, A2. Location in patent: Page/Page column 125-126
[5] Patent: JP2016/124825, 2016, A
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE manufacturers
- Product
- 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 335654-06-3
- Price
- US $32.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-22
- Product
- 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine 335654-06-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine 335654-06-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.3%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26