3-Chloro-6-iodopyridazine
- Product Name
- 3-Chloro-6-iodopyridazine
- CAS No.
- 135034-10-5
- Chemical Name
- 3-Chloro-6-iodopyridazine
- Synonyms
- SW-116;SWF-116;3-Chloro-6-pyrazine;3-Chloro-6-iodopyridazine;3-Chloro-6-iodo-1,2-diazine;Pyridazine, 3-chloro-6-iodo-;3-Chloro-6-iodopyridazine,97%;3-
Chloro- 6- iodopyridazine;3-Chloro-6-iodopyridazine ISO 9001：2015 REACH;3-Chloro-6-iodopyridazine Pyridazine, 3-chloro-6-iodo- - CBNumber
- CB71180395
- Molecular Formula
- C4H2ClIN2
- Formula Weight
- 240.43
- MOL File
- 135034-10-5.mol
3-Chloro-6-iodopyridazine Property
- Melting point:
- 118-120°
- Boiling point:
- 327.7±22.0 °C(Predicted)
- Density
- 2.187±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -1.18±0.10(Predicted)
- form
- Solid
- Appearance
- White to light brown Solid
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C4H2ClIN2/c5-3-1-2-4(6)8-7-3/h1-2H
- InChIKey
- PNEPCDPKMXJYIQ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NN=C(I)C=C1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- KOB0085
- Product name
- 3-Chloro-6-iodopyridazine
- Packaging
- 1 g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- C371598
- Product name
- 3-Chloro-6-iodopyridazine
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC45409
- Product name
- 3-Chloro-6-iodopyridazine
- Packaging
- 5G
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 3H32-M-X0
- Product name
- 3-Chloro-6-iodopyridazine
- Packaging
- 5G
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 044236
- Product name
- 3-Chloro-6-iodopyridazine
- Purity
- >95%
- Packaging
- 1g
- Price
- $97
- Updated
- 2021/12/16
3-Chloro-6-iodopyridazine Chemical Properties,Usage,Production
Uses
3-Chloro-6-iodopyridazine is a reactant in the Suzuki-Miyaura coupling reaction as well as a reactant in the synthesis of 6-Chloropyridazine-3-carbonitrile (C368635).
Synthesis
141-30-0
135034-10-5
The general procedure for the synthesis of 3-chloro-6-iodopyridazine from 3,6-dichloropyridazine was as follows: the intermediate (E)-3-{3-[3'-(1-adamantyl)-4'-hydroxyphenyl]-6-pyridazinyl}-2-propenoic acid ethyl ester was prepared as follows. a) Synthesis of 3-chloro-6-iodopyridazine. Followed the method reported in the literature (Goodman, A.J. et al., Tetrahedron, 1999, 55, 15067-15070). A suspension of 3,6-dichloropyridazine (5.000 g, 33.56 mmol), NaI (6.75 g, 45.0 mmol), and HI (55% to 58%, 25 mL) was stirred for 23 h at 44 °C (oil bath) under argon protection. After completion of the reaction, the mixture was cooled to room temperature and quenched with concentrated HCl. Subsequently, the pH was adjusted to 12 with NaOH, stirred for 10 min and extracted with CH2Cl2. The organic phase was washed with water and dried. The solvent was removed under reduced pressure to give 7.96 g (98% yield) of 3-chloro-6-iodopyridazine as a light yellow solid with a melting point of 114-116 °C (literature value: 110-112 °C). 1H NMR (CDCl3) δ 7.23 (d, J = 8.7 Hz, 1H, 4-ArH), 7.84 ppm (d, J = 8.7 Hz, 1H, 5-ArH).
References
[1] Patent: US2010/4443, 2010, A1. Location in patent: Page/Page column 34
[2] Patent: WO2011/79305, 2011, A1. Location in patent: Page/Page column 41
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 11, p. 3793 - 3816
[4] Tetrahedron, 1999, vol. 55, # 52, p. 15067 - 15070
[5] Patent: US2005/234046, 2005, A1. Location in patent: Page/Page column 66
3-Chloro-6-iodopyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloro-6-iodopyridazine manufacturers
- Product
- 3-Chloro-6-iodopyridazine 135034-10-5
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- 3-Chloro-6-iodopyridazine 135034-10-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-14
- Product
- 3-Chloro-6-iodopyridazine 135034-10-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25