ChemicalBook > CAS DataBase List > 5-Bromopyrimidine
5-Bromopyrimidine
- Product Name
- 5-Bromopyrimidine
- CAS No.
- 4595-59-9
- Chemical Name
- 5-Bromopyrimidine
- Synonyms
- 5-bromo-pyrimidin;5-pyriMidine;5-Brompyrimidin;5-BROMOPYRIMIDINE;5-Bromo-1,3-diazine;PYRIMIDINE, 5-BROMO-;PYRIMIDINE, 2-BROMO-;5-Bromopyrimidine,98%;5-Bromopyrimidine >5-BROMOPYRIMIDINE 0.98
- CBNumber
- CB8853640
- Molecular Formula
- C4H3BrN2
- Formula Weight
- 158.98
- MOL File
- 4595-59-9.mol
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5-Bromopyrimidine Property
- Melting point:
- 67-73 °C (lit.)
- Boiling point:
- 168°C(lit.)
- Density
- 1.6448 (rough estimate)
- refractive index
- 1.5260 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in chloroform.
- form
- Crystalline Powder or Chunks
- pka
- 1.40±0.10(Predicted)
- color
- Yellow to beige-brown
- BRN
- 107326
- InChI
- InChI=1S/C4H3BrN2/c5-4-1-6-3-7-2-4/h1-3H
- InChIKey
- GYCPLYCTMDTEPU-UHFFFAOYSA-N
- SMILES
- C1=NC=C(Br)C=N1
- CAS DataBase Reference
- 4595-59-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyrimidine, 5-bromo-(4595-59-9)
- EPA Substance Registry System
- Pyrimidine, 5-bromo- (4595-59-9)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- T
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29335990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 219142
- Product name
- 5-Bromopyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $40.41
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 219142
- Product name
- 5-Bromopyrimidine
- Purity
- 97%
- Packaging
- 25g
- Price
- $87.9
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2229
- Product name
- 5-Bromopyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $72
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2229
- Product name
- 5-Bromopyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $288
- Updated
- 2025/07/31
TRC
- Product number
- B686855
- Product name
- 5-Bromopyrimidine
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
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5-Bromopyrimidine Chemical Properties,Usage,Production
Description
5-Bromopyrimidine is an important structural unit in organic compounds, featuring a bromine functional group on its pyrimidine ring which serves as the active moiety enabling participation in diverse chemical reactions. Through acid-catalysed electrophilic alkylation of aromatic compounds with 5-bromopyrimidine, followed by oxidative rearrangement to form the dihydropyrimidine ring. Subsequent Sonogashira cross-coupling enables the preparation of 4-aryl-5-pyrimidylacetylene derivatives, which possess medicinal value.
Chemical Properties
yellow solid crystalline, insoluble in water, soluble in organic solvents such as benzene and toluene.
Uses
5-Bromopyrimidine was used in the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction, (5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol.
Uses
5-Bromopyrimidine was used in the synthesis of:
N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction
(5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol
Intermediate for the synthesis of plant growth regulator flurprimidol
Application
5-Bromopyrimidine is a compound useful in organic synthesis.
Preparation
5-Bromopyrimidine is prepared by reacting dibromodifuranone with formamide in the presence of B2O2 catalyst at 180-185°C to obtain the product.
General Description
Rapid nucleophilic displacement reactions of 5-bromopyrimidine with nucleophiles under microwave irradiation has been studied. 5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine.
5-Bromopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromopyrimidine manufacturers
Shandong Vital Biotechnology Co., Ltd.
- Product
- 5-Bromopyrimidine 4595-59-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 5-Bromopyrimidine 4595-59-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- 100kg
- Release date
- 2023-01-13
Zhengzhou Alfa Chemical Co.,Ltd
- Product
- 5-Bromopyrimidine 4595-59-9
- Price
- US $238.00/g
- Min. Order
- 1g
- Purity
- 97% min.
- Supply Ability
- 300kg
- Release date
- 2021-03-26
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