5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester
- Product Name
- 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester
- CAS No.
- 1214336-41-0
- Chemical Name
- 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester
- Synonyms
- Methyl 5-broMo-3-chloropicolinate;Methyl 5-broMo-3-chloropyridine-2-carboxylate;5-Bromo-3-Chloropyridinecarboxylic acid methyl ester;5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester;3-chloro-5-bromo-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 5-bromo-3-chloro-, methyl ester;5-Bromo-3-chloro-2-(methoxycarbonyl)pyridine, Methyl 5-bromo-3-chloropicolinate
- CBNumber
- CB62547048
- Molecular Formula
- C7H5BrClNO2
- Formula Weight
- 250.48
- MOL File
- 1214336-41-0.mol
5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Property
- Boiling point:
- 311℃
- Density
- 1.684
- Flash point:
- 142℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -3.26±0.10(Predicted)
- form
- crystalline powder
- color
- White
- InChI
- InChI=1S/C7H5BrClNO2/c1-12-7(11)6-5(9)2-4(8)3-10-6/h2-3H,1H3
- InChIKey
- QBNSPYFGGCZDJG-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=C(Br)C=C1Cl
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B682160
- Product name
- 5-Bromo-3-chloro-2-pyridinecarboxylicAcidMethylEster
- Packaging
- 1g
- Price
- $295
- Updated
- 2021/12/16
- Product number
- B682160
- Product name
- 5-Bromo-3-chloro-2-pyridinecarboxylicAcidMethylEster
- Packaging
- 5G
- Price
- $550
- Updated
- 2021/12/16
- Product number
- 188106
- Product name
- Methyl 5-bromo-3-chloropyridine-2-carboxylate
- Packaging
- 25g
- Price
- $750
- Updated
- 2021/12/16
- Product number
- 188106
- Product name
- Methyl 5-bromo-3-chloropyridine-2-carboxylate
- Packaging
- 10g
- Price
- $376
- Updated
- 2021/12/16
- Product number
- 3840AA
- Product name
- Methyl5-bromo-3-chloropicolinate
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
5-Bromo-3-chloro-2-pyridinecarboxylic Acid Methyl Ester is an intermediate used to prepare aminopyridinyldihydrooxazine derivatives for use as BACE-1 and/or BACE-2 inhibitors.
Synthesis
67-56-1
1189513-51-6
1214336-41-0
To a solution of dichloromethane (700 mL) containing traces of turbid 5-bromo-3-chloropyridine-2-carboxylic acid (60 g, 183.2 mmol), N,N-dimethylformamide (1 mL) and oxalyl chloride (24.9 mL, 286.9 mmol) were added slowly and dropwise. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the resulting yellow solution was cooled to 10 °C and methanol (30.8 mL, 761.3 mmol) was slowly added dropwise at this temperature, keeping the reaction temperature between 15 °C and 20 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature overnight. At the end of the reaction, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate solution, followed by washing the organic layer with brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give methyl 5-bromo-3-chloro-2-pyridinecarboxylate (55 g) as a yellow solid, which could be used in the next reaction without further purification.LCMS (Method B): m/z 250/252/254 (M + 1), retention time 1.12 min.
References
[1] Patent: WO2015/160636, 2015, A1. Location in patent: Page/Page column 164
[2] Patent: WO2015/160634, 2015, A1. Location in patent: Page/Page column 145
[3] Patent: WO2016/46071, 2016, A1. Location in patent: Page/Page column 61
[4] Patent: WO2016/87265, 2016, A1. Location in patent: Page/Page column 62; 63
[5] Patent: WO2016/87257, 2016, A1. Location in patent: Page/Page column 67-68
5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester Suppliers
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- sales@ajchem.in
- Country
- India
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View Lastest Price from 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester manufacturers
- Product
- 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester 1214336-41-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester 1214336-41-0
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester 1214336-41-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02