1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE

Product Name: 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE
CAS No.: 214701-49-2
Chemical Name: 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE
Synonyms: 1-(5-Bromopyridin-2-yl)ethan-1-one;5-Bromo-2-acetopyridine;2-Acetyl-5-bromopyridine;5-BROMO-2-ACETYLPYRIDINE;2-Acetyl-5-bromopyridine 98%;1-(5-Bromo-2-pyridyl)ethanone;1-(5-bromo-2-pyridinyl)ethanone;1-(5-Bromopyridine-2-yl)ethanone;1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE;Ethanone, 1-(5-broMo-2-pyridinyl)-
CBNumber: CB1288999
Molecular Formula: C7H6BrNO
Formula Weight: 200.03
MOL File: 214701-49-2.mol

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1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE Property

Melting point:: 112 °C
Boiling point:: 257.2±25.0 °C(Predicted)
Density: 1.534±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Sparingly)
form: Solid
pka: 0?+-.0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C7H6BrNO/c1-5(10)7-3-2-6(8)4-9-7/h2-4H,1H3
InChIKey: IDZRAUUUHXQGKC-UHFFFAOYSA-N
SMILES: C(=O)(C1=NC=C(Br)C=C1)C

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B679130
Product name: 1-(5-Bromo-2-pyridyl)ethanone
Packaging: 10g
Price: $280
Updated: 2021/12/16

AK Scientific

Product number: J94771
Product name: 2-Acetyl-5-Bromopyridine
Packaging: 1g
Price: $40
Updated: 2021/12/16

Matrix Scientific

Product number: 073338
Product name: 2-Acetyl-5-bromopyridine
Purity: 95+%
Packaging: 1g
Price: $49
Updated: 2021/12/16

Apolloscientific

Product number: OR51752
Product name: 2-Acetyl-5-bromopyridine
Packaging: 1g
Price: $61
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H17-9-X4
Product name: 2-Acetyl-5-bromopyridine
Purity: 98%
Packaging: 1g
Price: $68
Updated: 2021/12/16

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1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE Chemical Properties,Usage,Production

Uses

1-(5-Bromo-2-pyridyl)ethanone is a reagent used to synthesize substituted pyridin-3-yl)phenyloxazolidinones as antibacterial agents with reduced activity against monoamine oxidase A.

Synthesis

624-28-2

127-19-5

214701-49-2

2,5-Dibromopyridine (I-1-1) 8 g (33.7 mmol) was stirred with 337 mL of toluene at -40 °C in a nitrogen atmosphere. After stirring for 40 min, 21.4 mL (1.02 eq.) of a hexane solution of 1.6 M n-butyllithium was added slowly and dropwise to the reaction system, followed by 9.38 mL (3.0 eq.) of N,N-dimethylacetamide (DMAc). The reaction mixture was stirred and gradually warmed to 20 °C. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride, followed by extraction and liquid-liquid separation. The organic phase was purified by silica gel column chromatography to afford the target product 2-acetyl-5-bromopyridine (Compound I-1-2) 6.74 g in 100% yield as a white solid.

References

[1] Patent: JP2016/56276, 2016, A. Location in patent: Paragraph 0111; 0112
[2] Tetrahedron, 2008, vol. 64, # 17, p. 3794 - 3801
[3] Dalton Transactions, 2011, vol. 40, # 29, p. 7534 - 7540
[4] Journal of the American Chemical Society, 2016, vol. 138, # 38, p. 12643 - 12647
[5] Patent: WO2015/27021, 2015, A1. Location in patent: Page/Page column 78

1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE Suppliers

China 193 Germany 3 India 4 Switzerland 1 United Kingdom 2 United States 17 Global 220

Hangzhou Disynthesis Chemical Technology Co., Ltd.

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View Lastest Price from 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(5-Bromopyridin-2-yl)ethanone 214701-49-2
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Dideu Industries Group Limited

Product: 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE 214701-49-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-18

Career Henan Chemical Co

Product: 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE 214701-49-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-30

214701-49-2, 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONERelated Search:

2-Acetyl-3-fluoropyridine 2-Acetylpyridine 1-(2-BROMO-PYRIDIN-3-YL)-ETHANONE 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 3-ACETYL-5-BROMOPYRIDINE 2-BROMO-1-(6-BROMO-PYRIDIN-2-YL)-ETHANONE BIS(5-BROMO-2-PYRIDINYL)METHANONE 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE (5-BROMO-PYRIDIN-2-YL)-PHENYL-METHANONE 1-(5-BROMO-PYRIDIN-2-YL)-2,2,2-TRIFLUORO-ETHANONE ethyl 3-(5-bromopyridin-2-yl)-3-oxopropanoate 1-(3,5-DIBROMO-PYRIDIN-2-YL)-ETHANONE 7-Bromo-4-oxo-1,4-dihydro-[1,5]naphthyridine-2-carboxylic acid ethyl ester

Ethanone, 1-(5-broMo-2-pyridinyl)-

1-(5-Bromopyridin-2-yl)ethan-1-one, 5-Bromo-2-ethanoylpyridine

1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE

5-BROMO-2-ACETYLPYRIDINE

2-Acetyl-5-bromopyridine

1-(5-bromo-2-pyridinyl)ethanone

5-Bromo-2-acetopyridine

1-(5-Bromopyridin-2-yl)ethan-1-one

2-Acetyl-5-bromopyridine 98%

1-(5-Bromopyridine-2-yl)ethanone

1-(5-Bromo-2-pyridyl)ethanone

1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE ISO 9001：2015 REACH

214701-49-2

Pyridines

Heterocycle-Pyridine series

API intermediates