3-ACETYL-5-BROMOPYRIDINE
- Product Name
- 3-ACETYL-5-BROMOPYRIDINE
- CAS No.
- 38940-62-4
- Chemical Name
- 3-ACETYL-5-BROMOPYRIDINE
- Synonyms
- 5-Acetyl-3-bromopyridine;3-BROMO-5-ACETYLPYRIDINE;3-ACETYL-5-BROMOPYRIDINE;5-Bromo-3-acetylpyridine;3-Acetyl-5-bromopyridine,97%;3-Acetyl-5-bromopyridine >1-(5-Bromo-3-pyridyl)ethanone;1-(5-bromo-3-pyridinyl)ethanone;1-(5-BROMOPYRIDIN-3-YL)ETHANONE;Ethanone, 1-(5-bromo-3-pyridinyl)-
- CBNumber
- CB6272959
- Molecular Formula
- C7H6BrNO
- Formula Weight
- 200.03
- MOL File
- 38940-62-4.mol
3-ACETYL-5-BROMOPYRIDINE Property
- Melting point:
- 77-79°C
- Boiling point:
- 279.3±25.0 °C(Predicted)
- Density
- 1.534±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 1.08±0.20(Predicted)
- color
- White to Light yellow
- BRN
- 112808
- InChIKey
- LDBPZEQZCOUYFT-UHFFFAOYSA-N
- CAS DataBase Reference
- 38940-62-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-36/37-36
- WGK Germany
- 3
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 703893
- Product name
- 3-Acetyl-5-bromopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $184
- Updated
- 2023/06/20
- Product number
- 703893
- Product name
- 3-Acetyl-5-bromopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $157
- Updated
- 2022/05/15
- Product number
- A2376
- Product name
- 3-Acetyl-5-bromopyridine
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- A2376
- Product name
- 3-Acetyl-5-bromopyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $97
- Updated
- 2025/07/31
- Product number
- A168510
- Product name
- 3-Acetyl-5-bromopyridine
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
3-ACETYL-5-BROMOPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
Hoar or pale yellow solid
Uses
3-Acetyl-5-bromopyridine is used in the synthesis of benzimidazole CYP11B2 inhibitors. Potent and selective aldosterone inhibitors are used to treat diseases such as those resulting in the stiffening of the heart.
Synthesis
75-16-1
183608-47-1
38940-62-4
To a solution of 5-bromo-N-methoxy-N-methylnicotinamide (2.08 g, 8.5 mmol) in tetrahydrofuran (THF, 20 mL) was slowly added methylmagnesium bromide (MeMgBr, 1.52 g, 12.75 mmol) at -78 °C. The reaction mixture was stirred at room temperature for 2 h before the reaction was quenched with deionized water. Subsequently, the reaction mixture was extracted with ethyl acetate (EtOAc) and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure and the resulting residue was purified by fast column chromatography to afford the target product 3-acetyl-5-bromopyridine (1.5 g, 88% yield).
References
[1] Patent: US2013/72679, 2013, A1. Location in patent: Paragraph 0893; 0894
[2] Patent: WO2013/37779, 2013, A1. Location in patent: Page/Page column 235; 236
3-ACETYL-5-BROMOPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-ACETYL-5-BROMOPYRIDINE manufacturers
- Product
- 3-ACETYL-5-BROMOPYRIDINE 38940-62-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 3-ACETYL-5-BROMOPYRIDINE 38940-62-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 3-ACETYL-5-BROMOPYRIDINE 38940-62-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10