5-Acetyl-2-bromopyridine

Product Name: 5-Acetyl-2-bromopyridine
CAS No.: 139042-59-4
Chemical Name: 5-Acetyl-2-bromopyridine
Synonyms: 1-(6-Bromopyridin-3-yl)ethan-1-one;2-BROMO-5-ACETYLPYRIDINE;3-ACETYL-6-BROMOPYRIDINE;5-Acetyl-2-bromopyridine 97%;1-(6-Bromopyrid-3-yl)ethan-1-one;EOS-60530;CAS:139042-59-4;Abemaciclib Impurity 60;5-acetyl-2-bromopyridine;5-Acetyl-2-bromopyridine >
CBNumber: CB3392276
Molecular Formula: C7H6BrNO
Formula Weight: 200.03
MOL File: 139042-59-4.mol

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5-Acetyl-2-bromopyridine Property

Melting point:: 124-128 °C (lit.)
Boiling point:: 304.7±27.0 °C(Predicted)
Density: 1.534±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: -1.01±0.10(Predicted)
color: Light orange to Yellow to Green
InChI: InChI=1S/C7H6BrNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3
InChIKey: MUKKGHQBUKOMTD-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(Br)N=C1)C
CAS DataBase Reference: 139042-59-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595942
Product name: 5-Acetyl-2-bromopyridine
Purity: 97%
Packaging: 1g
Price: $120
Updated: 2023/01/07

Sigma-Aldrich

Product number: 595942
Product name: 5-Acetyl-2-bromopyridine
Purity: 97%
Packaging: 5g
Price: $330
Updated: 2021/12/16

TCI Chemical

Product number: A2421
Product name: 5-Acetyl-2-bromopyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: A2421
Product name: 5-Acetyl-2-bromopyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $142
Updated: 2025/07/31

TRC

Product number: B679323
Product name: 2-Bromo-5-acetylpyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

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5-Acetyl-2-bromopyridine Chemical Properties,Usage,Production

Uses

5-Acetyl-2-bromopyridine is used as biochemical reagent and organic intermediate.

Synthesis

624-28-2

127-19-5

139042-59-4

Step 1: Synthesis of 1-(6-bromopyridin-3-yl)ethanone To a stirred solution of 2,5-dibromopyridine (1.0 g, 4.219 mmol) in ether (10 mL) was slowly added n-butyllithium (2.0 mL, 5.0 mmol, 2.5 M hexane solution) at -78 °C and the reaction was carried out under nitrogen protection. After keeping stirring at -78 °C for 1 h, N,N-dimethylacetamide (0.58 g, 6.3 mmol) was added dropwise and stirring was continued at -78 °C for 4 h. The reaction was carried out under nitrogen protection. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with ice water and subsequently partitioned between saturated ammonium chloride (NH4Cl) solution and ethyl acetate (EtOAc). The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1-(6-bromopyridin-3-yl)ethanone (0.4 g, 47% yield) as a yellow solid. Mass spectrometry (MS) showed a molecular ion peak m/z 200.1 [M++1].

References

[1] Molecules, 2008, vol. 13, # 4, p. 818 - 830
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6763 - 6770
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 11, p. 3860 - 3874
[4] Patent: US2017/291894, 2017, A1. Location in patent: Paragraph 0428
[5] Chemische Berichte, 1992, vol. 125, # 5, p. 1169 - 1190

5-Acetyl-2-bromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Acetyl-2-bromopyridine Suppliers

Americas 1 Australia 1 Belgium 3 China 239 Europe 1 France 2 Germany 8 India 13 Japan 2 Switzerland 3 The Netherlands 1 United Kingdom 7 United States 53 Global 334

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View Lastest Price from 5-Acetyl-2-bromopyridine manufacturers

LY Global chemicals co.,ltd .

Product: 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 139042-59-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2023-03-27

Honest Joy Holdings Limited

Product: 2-Bromo-5-acetylpyridine 139042-59-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.9%
Supply Ability: 100 tons
Release date: 2022-01-26

Dideu Industries Group Limited

Product: 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 139042-59-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-18

139042-59-4, 5-Acetyl-2-bromopyridineRelated Search:

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5-Acetyl-2-bromopyridine 97%

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EOS-60530

5-Acetyl-2-bromopyridine &gt

1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE ISO 9001：2015 REACH

-(6-BROMO-PYRIDIN-3-YL)-ETHANONE

1-(6-Bromo-3-pyridinyl)ethanone

CAS:139042-59-4

Abemaciclib Impurity 60

139042-59-4

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