ChemicalBook > CAS DataBase List > 5-Acetyl-2-bromopyridine

5-Acetyl-2-bromopyridine

Product Name
5-Acetyl-2-bromopyridine
CAS No.
139042-59-4
Chemical Name
5-Acetyl-2-bromopyridine
Synonyms
1-(6-Bromopyridin-3-yl)ethan-1-one;2-BROMO-5-ACETYLPYRIDINE;3-ACETYL-6-BROMOPYRIDINE;5-Acetyl-2-bromopyridine 97%;1-(6-Bromopyrid-3-yl)ethan-1-one;EOS-60530;CAS:139042-59-4;Abemaciclib Impurity 60;5-acetyl-2-bromopyridine;5-Acetyl-2-bromopyridine >
CBNumber
CB3392276
Molecular Formula
C7H6BrNO
Formula Weight
200.03
MOL File
139042-59-4.mol
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5-Acetyl-2-bromopyridine Property

Melting point:
124-128 °C (lit.)
Boiling point:
304.7±27.0 °C(Predicted)
Density 
1.534±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-1.01±0.10(Predicted)
color 
Light orange to Yellow to Green
InChI
InChI=1S/C7H6BrNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3
InChIKey
MUKKGHQBUKOMTD-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(Br)N=C1)C
CAS DataBase Reference
139042-59-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
595942
Product name
5-Acetyl-2-bromopyridine
Purity
97%
Packaging
1g
Price
$120
Updated
2023/01/07
Sigma-Aldrich
Product number
595942
Product name
5-Acetyl-2-bromopyridine
Purity
97%
Packaging
5g
Price
$330
Updated
2021/12/16
TCI Chemical
Product number
A2421
Product name
5-Acetyl-2-bromopyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$45
Updated
2025/07/31
TCI Chemical
Product number
A2421
Product name
5-Acetyl-2-bromopyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$142
Updated
2025/07/31
TRC
Product number
B679323
Product name
2-Bromo-5-acetylpyridine
Packaging
1g
Price
$75
Updated
2021/12/16
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5-Acetyl-2-bromopyridine Chemical Properties,Usage,Production

Uses

5-Acetyl-2-bromopyridine is used as biochemical reagent and organic intermediate.

Synthesis

624-28-2

127-19-5

139042-59-4

Step 1: Synthesis of 1-(6-bromopyridin-3-yl)ethanone To a stirred solution of 2,5-dibromopyridine (1.0 g, 4.219 mmol) in ether (10 mL) was slowly added n-butyllithium (2.0 mL, 5.0 mmol, 2.5 M hexane solution) at -78 °C and the reaction was carried out under nitrogen protection. After keeping stirring at -78 °C for 1 h, N,N-dimethylacetamide (0.58 g, 6.3 mmol) was added dropwise and stirring was continued at -78 °C for 4 h. The reaction was carried out under nitrogen protection. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with ice water and subsequently partitioned between saturated ammonium chloride (NH4Cl) solution and ethyl acetate (EtOAc). The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1-(6-bromopyridin-3-yl)ethanone (0.4 g, 47% yield) as a yellow solid. Mass spectrometry (MS) showed a molecular ion peak m/z 200.1 [M++1].

References

[1] Molecules, 2008, vol. 13, # 4, p. 818 - 830
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6763 - 6770
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 11, p. 3860 - 3874
[4] Patent: US2017/291894, 2017, A1. Location in patent: Paragraph 0428
[5] Chemische Berichte, 1992, vol. 125, # 5, p. 1169 - 1190

5-Acetyl-2-bromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Acetyl-2-bromopyridine Suppliers

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View Lastest Price from 5-Acetyl-2-bromopyridine manufacturers

LY Global chemicals co.,ltd .
Product
1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 139042-59-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2023-03-27
Honest Joy Holdings Limited
Product
2-Bromo-5-acetylpyridine 139042-59-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-01-26
Dideu Industries Group Limited
Product
1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 139042-59-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-18

139042-59-4, 5-Acetyl-2-bromopyridineRelated Search:

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  • EOS-60530
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  • 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE ISO 9001：2015 REACH
  • -(6-BROMO-PYRIDIN-3-YL)-ETHANONE
  • 1-(6-Bromo-3-pyridinyl)ethanone
  • CAS:139042-59-4
  • Abemaciclib Impurity 60
  • 139042-59-4
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