ChemicalBook > CAS DataBase List > 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE

1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE

Product Name
1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE
CAS No.
214701-49-2
Chemical Name
1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE
Synonyms
1-(5-Bromopyridin-2-yl)ethan-1-one;5-Bromo-2-acetopyridine;2-Acetyl-5-bromopyridine;5-BROMO-2-ACETYLPYRIDINE;2-Acetyl-5-bromopyridine 98%;1-(5-Bromo-2-pyridyl)ethanone;1-(5-bromo-2-pyridinyl)ethanone;1-(5-Bromopyridine-2-yl)ethanone;1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE;Ethanone, 1-(5-broMo-2-pyridinyl)-
CBNumber
CB1288999
Molecular Formula
C7H6BrNO
Formula Weight
200.03
MOL File
214701-49-2.mol
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1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE Property

Melting point:
112 °C
Boiling point:
257.2±25.0 °C(Predicted)
Density 
1.534±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Sparingly)
form 
Solid
pka
0?+-.0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C7H6BrNO/c1-5(10)7-3-2-6(8)4-9-7/h2-4H,1H3
InChIKey
IDZRAUUUHXQGKC-UHFFFAOYSA-N
SMILES
C(=O)(C1=NC=C(Br)C=C1)C
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B679130
Product name
1-(5-Bromo-2-pyridyl)ethanone
Packaging
10g
Price
$280
Updated
2021/12/16
AK Scientific
Product number
J94771
Product name
2-Acetyl-5-Bromopyridine
Packaging
1g
Price
$40
Updated
2021/12/16
Matrix Scientific
Product number
073338
Product name
2-Acetyl-5-bromopyridine
Purity
95+%
Packaging
1g
Price
$49
Updated
2021/12/16
Apolloscientific
Product number
OR51752
Product name
2-Acetyl-5-bromopyridine
Packaging
1g
Price
$61
Updated
2021/12/16
SynQuest Laboratories
Product number
4H17-9-X4
Product name
2-Acetyl-5-bromopyridine
Purity
98%
Packaging
1g
Price
$68
Updated
2021/12/16
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1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE Chemical Properties,Usage,Production

Uses

1-(5-Bromo-2-pyridyl)ethanone is a reagent used to synthesize substituted pyridin-3-yl)phenyloxazolidinones as antibacterial agents with reduced activity against monoamine oxidase A.

Synthesis

624-28-2

127-19-5

214701-49-2

2,5-Dibromopyridine (I-1-1) 8 g (33.7 mmol) was stirred with 337 mL of toluene at -40 °C in a nitrogen atmosphere. After stirring for 40 min, 21.4 mL (1.02 eq.) of a hexane solution of 1.6 M n-butyllithium was added slowly and dropwise to the reaction system, followed by 9.38 mL (3.0 eq.) of N,N-dimethylacetamide (DMAc). The reaction mixture was stirred and gradually warmed to 20 °C. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride, followed by extraction and liquid-liquid separation. The organic phase was purified by silica gel column chromatography to afford the target product 2-acetyl-5-bromopyridine (Compound I-1-2) 6.74 g in 100% yield as a white solid.

References

[1] Patent: JP2016/56276, 2016, A. Location in patent: Paragraph 0111; 0112
[2] Tetrahedron, 2008, vol. 64, # 17, p. 3794 - 3801
[3] Dalton Transactions, 2011, vol. 40, # 29, p. 7534 - 7540
[4] Journal of the American Chemical Society, 2016, vol. 138, # 38, p. 12643 - 12647
[5] Patent: WO2015/27021, 2015, A1. Location in patent: Page/Page column 78

1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-(5-Bromopyridin-2-yl)ethanone 214701-49-2
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
Dideu Industries Group Limited
Product
1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE 214701-49-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-18
Career Henan Chemical Co
Product
1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE 214701-49-2
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-30

214701-49-2, 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONERelated Search:

2-Acetyl-3-fluoropyridine 2-Acetylpyridine 1-(2-BROMO-PYRIDIN-3-YL)-ETHANONE 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 3-ACETYL-5-BROMOPYRIDINE 2-BROMO-1-(6-BROMO-PYRIDIN-2-YL)-ETHANONE BIS(5-BROMO-2-PYRIDINYL)METHANONE 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE (5-BROMO-PYRIDIN-2-YL)-PHENYL-METHANONE 1-(5-BROMO-PYRIDIN-2-YL)-2,2,2-TRIFLUORO-ETHANONE ethyl 3-(5-bromopyridin-2-yl)-3-oxopropanoate 1-(3,5-DIBROMO-PYRIDIN-2-YL)-ETHANONE 7-Bromo-4-oxo-1,4-dihydro-[1,5]naphthyridine-2-carboxylic acid ethyl ester

  • Ethanone, 1-(5-broMo-2-pyridinyl)-
  • 1-(5-Bromopyridin-2-yl)ethan-1-one, 5-Bromo-2-ethanoylpyridine
  • 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE
  • 5-BROMO-2-ACETYLPYRIDINE
  • 2-Acetyl-5-bromopyridine
  • 1-(5-bromo-2-pyridinyl)ethanone
  • 5-Bromo-2-acetopyridine
  • 1-(5-Bromopyridin-2-yl)ethan-1-one
  • 2-Acetyl-5-bromopyridine 98%
  • 1-(5-Bromopyridine-2-yl)ethanone
  • 1-(5-Bromo-2-pyridyl)ethanone
  • 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE ISO 9001：2015 REACH
  • 214701-49-2
  • Pyridines
  • Heterocycle-Pyridine series
  • API intermediates