Methyl 6-bromonicotinate
- Product Name
- Methyl 6-bromonicotinate
- CAS No.
- 26218-78-0
- Chemical Name
- Methyl 6-bromonicotinate
- Synonyms
- Methyl 6-bromoni;6-bromonicotinate;Methyl 6-bromonicotite;Methyl-6-bromonictinate;METHYL 6-BROMONICOTINATE;6- broMoMethyl nicotinate;Methyl 6-bromonicotinate 98%;Methyl 6-Bromonicotinate >6-Bromonicotinic acid ethyl ester;6-BROMONICOTINIC ACID METHYL ESTER
- CBNumber
- CB1673058
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 26218-78-0.mol
Methyl 6-bromonicotinate Property
- Melting point:
- 119-121
- Boiling point:
- 107-110 °C(Press: 4 Torr)
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- pka
- -1.25±0.10(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- InChI
- InChI=1S/C7H6BrNO2/c1-11-7(10)5-2-3-6(8)9-4-5/h2-4H,1H3
- InChIKey
- NFLROFLPSNZIAH-UHFFFAOYSA-N
- SMILES
- C1=NC(Br)=CC=C1C(OC)=O
- CAS DataBase Reference
- 26218-78-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M2682
- Product name
- Methyl 6-Bromonicotinate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- M2682
- Product name
- Methyl 6-Bromonicotinate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $94
- Updated
- 2025/07/31
- Product number
- M296133
- Product name
- Methyl 6-Bromonicotinate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR9561
- Product name
- Methyl 6-Bromonicotinate
- Purity
- 97%
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 44718
- Product name
- Methyl6-Bromonicotinate,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 5G
- Price
- $88.1
- Updated
- 2021/12/16
Methyl 6-bromonicotinate Chemical Properties,Usage,Production
Uses
A potential hypolipidemic agent; a nicotinic acid analog. Heterocyclic compounds affecting free fatty acid mobilization in vivo.
Synthesis
67-56-1
6311-35-9
26218-78-0
A 100 mL round bottom flask was charged with 6-bromonicotinic acid (540 mg, 2.7 mmol), methylene chloride (20 mL) and N,N-dimethylformamide (1 drop). Oxalyl chloride (1 mL) was then added slowly and vigorous gas escape was observed. The reaction mixture was stirred at room temperature for 1 h, after which the solvent was removed under reduced pressure by rotary evaporator. The residue was treated with methanol (MeOH) and the solvent was again removed under reduced pressure. The residue was dissolved in dichloromethane and washed with saturated sodium bicarbonate (NaHCO3) solution. The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give 369 mg of methyl 6-bromonicotinate in 55% yield. The product was characterized by 1H NMR (500 MHz): δ 9.00 (dd, J = 2.0, 0.5 Hz, 1H), 8.25 (dd, J = 8.5, 2.5 Hz, 1H), 7.42 (dd, J = 8.5, 0.5 Hz, 1H), 3.96 (s, 3H).
References
[1] Journal of the American Chemical Society, 2011, vol. 133, # 34, p. 13445 - 13454
[2] Heterocycles, 1994, vol. 38, # 7, p. 1551 - 1572
[3] Patent: WO2008/21388, 2008, A1. Location in patent: Page/Page column 191-192
[4] Patent: WO2018/126072, 2018, A1. Location in patent: Paragraph 0255; 0256
[5] Patent: US2014/18368, 2014, A1. Location in patent: Paragraph 0162; 0174
Methyl 6-bromonicotinate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Methyl 6-bromonicotinate manufacturers
- Product
- Methyl 6-bromonicotinate 26218-78-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- Methyl 6-bromonicotinate 26218-78-0
- Price
- US $49.00-311.00/g
- Min. Order
- 25g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-13
- Product
- Methyl 6-bromonicotinate 26218-78-0
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08