2,5-Dichloropyridine
Uses- Product Name
- 2,5-Dichloropyridine
- CAS No.
- 16110-09-1
- Chemical Name
- 2,5-Dichloropyridine
- Synonyms
- Dichloropyridine;4-Aminophenylacetamide;2,5- twochlorine pyridine;5-Dichloropyridine;2,5-Chloro pyridine;2,5-DICHLORPYRIDINE;2,5-dichloro-pyridin;2,5-DICHLOROPYRIDINE;2,5-Dichiloropyridine;Pyridine, 2,5-dichloro-
- CBNumber
- CB9487592
- Molecular Formula
- C5H3Cl2N
- Formula Weight
- 147.99
- MOL File
- 16110-09-1.mol
2,5-Dichloropyridine Property
- Melting point:
- 59-62 °C (lit.)
- Boiling point:
- 190-191 °C
- Density
- 1.5159 (rough estimate)
- refractive index
- 1.5500 (estimate)
- Flash point:
- 112 °C
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.25±0.10(Predicted)
- form
- Crystalline Solid
- color
- White to slightly yellow
- Water Solubility
- insoluble
- BRN
- 108886
- InChI
- InChI=1S/C5H3Cl2N/c6-4-1-2-5(7)8-3-4/h1-3H
- InChIKey
- GCTFDMFLLBCLPF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Cl)C=C1
- CAS DataBase Reference
- 16110-09-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-37/39-36
- RIDADR
- UN2811
- WGK Germany
- 3
- RTECS
- US8225000
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HazardClass
- 6.1
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 193763
- Product name
- 2,5-Dichloropyridine
- Purity
- 98%
- Packaging
- 10g
- Price
- $40.4
- Updated
- 2025/07/31
- Product number
- 193763
- Product name
- 2,5-Dichloropyridine
- Purity
- 98%
- Packaging
- 50g
- Price
- $129
- Updated
- 2023/06/20
- Product number
- D1607
- Product name
- 2,5-Dichloropyridine
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- D1607
- Product name
- 2,5-Dichloropyridine
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- D436155
- Product name
- 2,5-Dichloropyridine
- Packaging
- 50g
- Price
- $305
- Updated
- 2021/12/16
2,5-Dichloropyridine Chemical Properties,Usage,Production
Uses
2,5-Dichloropyridine is a reagent used in chemical synthesis. It has been used to synthesize 4-benzodiazepine-2,5 diones as Hdm2 antagonists and inhibitors of ERK protein kinase.
Chemical Properties
white to slightly yellow crystalline solid
Uses
2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.
Synthesis Reference(s)
Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514
General Description
2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.
Synthesis
624-28-2
16110-09-1
General procedure for the synthesis of 2,5-dichloropyridine from 2,5-dibromopyridine: Catalyst 1 (10 mol%), 2,5-dibromopyridine (1.0 mmol), tetramethylammonium chloride (Me4NCl, 2.0 mmol), and ethanol (EtOH, 2.0 mL) were added to a Schlenk tube under nitrogen protection. Schlenk tubes were sealed using polytetrafluoroethylene (Teflon) valves and the reaction mixture was stirred at 100 °C. The reaction process was monitored by gas chromatography (GC) analysis. After completion of the reaction, the solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent ratio petroleum ether/ethyl acetate = 10:1) to give 2,5-dichloropyridine. The yield of the product was determined by high-resolution gas chromatography-mass spectrometry (GC-MS) analysis and the structure was confirmed by comparing its physical properties and spectral data with known compounds.
References
[1] Applied Catalysis A: General, 2014, vol. 472, p. 178 - 183
[2] Chemical Communications, 2012, vol. 48, # 76, p. 9468 - 9470
2,5-Dichloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dichloropyridine manufacturers
- Product
- 2,5-Dichloropyridine 16110-09-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2,5-Dichloropyridine 16110-09-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 2,5-Dichloropyridine 16110-09-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17